Concentrate for a hemodialysis acid

General characteristics. Structure:

Structure of acid concentrates

 

Designation of a concentrate	Mass concentration of components, g/l
	NaCl	KCl	CaCl22H2O	MgCl26H2O	CH3COOH
KK-A-1	214,77	5,22	6,43	3,55	6,31
KK-A-2	214,77	5,22	7,72	3,55	6,31
KK-A-3	214,77	7,83	7,72	3,55	6,31
KK-A-4	214,77	5,22	9,01	5,34	6,31
KK-A-5	214,77	5,22	9,01	7,12	6,31

 

Structure of a bicarbonate concentrate

 

Designation concentrate	Mass concentration of components, g/l
	NaHCO3
BK-V-8,4	84

Pharmacological properties:

Pharmacodynamics. The main process of a hemodialysis happens on dialysis membranes between blood of the patient and dialysis solution. Blood of the patient flows on one side of a dialysis membrane, and dialyzate – on another in an opposite direction. At the expense of a difference in concentration and hydrostatic pressure there is a diffusion, ultrafiltration and convection of substances between blood and a dialysis fluid through a semipermeable membrane. Dializirushchy solution consists of the purified water and various substances dissolved in it. All substances as a part of dialyzate are electrolytes. The dialysis fluid regulates electrolytic and acid-base balance in an organism of the patient and deletes toxins - organism waste products.           

The dialysis fluid prepares in the dialysis device automatically, by continuous proportional mixing of a dialysis concentrate and the purified water. For carrying out bicarbonate dialysis acid and bicarbonate components are issued. Compositions of dialysis solution, ready to use, after cultivation in the ratio are brought in the table: 1 l of an acid concentrate + 1,225 l of a bicarbonate concentrate + 32,775 l of water.

Indications to use:

Concentrates are applied according to the application instruction approved by the Ministry of Health of Republic of Belarus.

Route of administration and doses:

Dialysis solution, ready to use, prepares by cultivation of an acid and bicarbonate concentrate the water purified in the ratio: 1 l of an acid concentrate + 1,225 l of a bicarbonate concentrate + 32,775 l of the water purified.
Composition of dialysis solution, ready to use

 

Designation of a concentrate	The maintenance of components in mmol/l
	Na +	K +	Ca2 +	Mg2 +	Cl-	Acetate -	HCO3-
KK-A-1	140	2,0	1,25	0,5	110,5	3,0	32
KK-A-2	140	2,0	1,5	0,5	111,0	3,0	32
KK-A-3	140	3,0	1,5	0,5	112,0	3,0	32
KK-A-4	140	2,0	1,75	0,75	112,0	3,0	32
KK-A-5	140	2,0	1,75	1,0	112,5	3,0	32

 
Before use of concentrates it is necessary:

 

1. To be convinced that information on the label corresponds to type of the carried-out dialysis.

2. To check integrity of control of the first opening on a cover.

3. To intensively mix canister contents.

4. To wipe a cover and a mouth with disinfectant solution.

5. To uncover a canister.

6. To lower in a canister a zabornik of a concentrate of the device for a hemodialysis.

7. Further to be guided by the maintenance instruction of devices for a hemodialysis.

Storage conditions:

• Concentrates transport all types of the covered transport according to rules of transportation of goods on this type of transport.
  
• Storage of concentrates has to be made in the pure, protected from moisture and light room at a temperature from plus 5 to plus 25 °C.
  
• It is forbidden to freeze a concentrate.

Issue conditions:

According to the recipe

Packaging:

- Concentrates spread in polymeric canisters on TNPA.

- Internal diameter of a mouth – 45 mm, height of a canister makes – 322 mm, diameter of a canister – maximum – 195 mm, minimum – 193 mm.

- The occluding cover has the stopping self-destroyed fixer for control of tightness of closing.  

- Each series of concentrates is delivered together with the application instruction and the passport. In case of division of a series into several deliveries, the application instruction and the passport are attached to each delivery.