The prices in Internet drugstores:
from 1600 rub.
Apidra – a recombinant analog of insulin human, equal to it on action force, but the rendering more bystry and less long effect.
Dosage form of Apidra – solution for hypodermic (п / to) introductions: almost colourless or colourless transparent liquid (on 10 ml in bottles, 1 bottle in a cardboard pack; on 3 ml in cartridges, in packaging of planimetric cell: 5 cartridges for the syringe handle "Optipen" or 5 cartridges which are built in in one-time the syringe handle "Optiset", or 5 cartridge Optiklik systems).
Contains in 1 ml of solution:
Apidra is applied to treatment of the diabetes mellitus demanding insulin therapy, at children 6 years are more senior, than teenagers and adult patients.
With care Apidra is recommended to be applied at pregnancy.
The insulin dose decline owing to reduction of a gluconeogenesis and delay of metabolism of insulin can be required by patients with a liver failure.
Decrease in need for insulin is also possible at a renal failure and at advanced age (for a cause of infringement of function of kidneys).
Apidr's insulin is entered just before meal (in 0-15 min.) or right after food by п / to an injection or continuous infusion into a hypodermic fatty tissue with use of pompovy system.
The dose and the mode of administration of drug are selected individually.
Apidr's solution is applied in complex schemes of therapy with insulin of average duration of action or with an insulin/analogue of insulin of long action, the combined use with peroral hypoglycemic drugs is allowed.
The recommended body parts for administration of drug:
It is necessary to alternate places of infusions and injections at each subsequent administration of drug.
As the dosage form of Apidra – solution, before its use of carrying out resuspending is not required.
Speed of absorption and, respectively, the beginning and duration of effect of drug can change under the influence of an exercise stress, depending on an injection site of solution and other changing factors.
It is required to be careful at administration of drug to exclude probability of its hit directly in blood vessels. After the procedure it is not necessary to mass area of introduction.
Patients it is necessary to teach technique of carrying out injections.
At administration of drug by means of pompovy system for insulin infusion solution cannot be mixed with any other medicinal substances / means.
Apidr's solution does not mix up with any other drugs except for human isophanes insulin. At the same time Apidra is taken in the syringe of the first, and the injection is carried out right after mixing. Data on use of the solutions mixed long before carrying out an injection no.
Cartridges it is necessary to use with insulin the syringe handle "Optipen Pro1" or similar devices in strict accordance with the recommendations about loading of a cartridge, accession of a needle and carrying out an injection of insulin provided in the instruction from the producer. Before use of a cartridge it is necessary to carry out a visual inspection of drug. Only the transparent, colourless, not containing visible firm inclusions solution suits for injections. Before installation the cartridge needs previously to be sustained within 1-2 hours at the room temperature, and before administration of solution it is necessary to remove vials of air from a cartridge.
The used cartridges cannot be filled repeatedly. Damaged the syringe handle "Optipen Pro1" it is impossible to use.
In case of malfunction the syringe handle solution can be gathered from a cartridge in the plastic syringe suitable for insulin in concentration of 100 ME/ml then to enter to the patient.
The syringe handle of reusable use is used to injections only to one patient (in order to avoid infection).
Also it is necessary to follow all above-mentioned recommendations and rules when using for administration of solution of Apidr of cartridge system and the syringe handle "Optiklik", representing glass cartridge with the attached piston mechanism fixed in a transparent plastic container and containing 3 ml of solution of insulin of a glulizin.
The most frequent undesirable side effect of an insulin therapy – a hypoglycemia; usually it arises when using insulin in the doses considerably exceeding required.
The side adverse reactions connected with administration of drug, from bodies and systems of patients, registered during clinical trials (the list is given with use of the following gradation of frequency of occurrence: more than 10% – are very frequent; more than 1%, but less than 10% – are frequent; more than 0,1%, but less than 1% – sometimes; more than 0,01%, but less than 0,1% – are rare; less than 0,01% – are very rare):
Special data on studying of symptoms of overdose of insulin of a glulizin are absent, but owing to long use of high doses of Apidra development of varying severity of a hypoglycemia is possible.
Therapy of a state depends on disease degree:
In case of transfer of the patient into insulin from other producer or new type of insulin strict medical observation as correction of the carried-out therapy in general can be required is necessary.
Use of insulin in inadequate doses or the unreasonable termination of therapy, especially at patients with a diabetes mellitus of 1 type, can become the reason of development of a hyperglycemia and diabetic ketoacidosis – potentially life-threatening states. Time of probable development of a hypoglycemia directly depends on the speed of effect of the applied insulin and can change in this regard at correction of the scheme of therapy.
The main conditions which can change or make less expressed symptoms of development of a hypoglycemia:
Correction of doses of insulin can be also necessary in case of change of the modes of a physical activity or food. The strengthened exercise stress received directly after meal can increase probability of development of a hypoglycemia. In comparison with effect of soluble human insulin the hypoglycemia can develop rather after introduction of high-speed analogs of insulin.
Owing to noncompensated hypo - or hyper glycemic reactions are possible a loss of consciousness, development of a coma or a lethal outcome.
Associated diseases or emotional overloads can also change need of the patient for insulin.
Researches on pharmacokinetic medicinal interaction of drug of Apidr were not conducted, but on the basis of the data which are available concerning similar medicines it is possible to draw a conclusion that clinically significant pharmacokinetic interaction is improbable.
Some medicinal substances / drugs are capable to exert impact on glucose metabolism owing to what correction of doses of insulin of a glulizin and more careful control of the carried-out therapy and a condition of the patient can be required.
So at combined use with Apidr's solution:
Researches of compatibility of insulin of a glulizin were not conducted therefore Apidr should not mix with any other drugs, an exception – human isophanes insulin.
In case of administration of solution by means of an infusional pomp Apidr cannot mix with other drugs.
To store in own cardboard packaging, without light access, at a temperature of 2-8 °C. Not to freeze. To protect from children!
After opening of packaging to store in the place protected from light at a temperature up to 25 °C. A drug period of validity after the first use – 4 weeks (on the label it is recommended to celebrate date of the first intake of solution).
Period of validity – 2 years.
Name of drug
Apidra Solostar piece syringe handle 100ed/ml3ml 5
Apidr's insulin Solostar solution for инъ 100ME/ml of 3 ml No. 5 shpr-ruch. *, Sanofi Aventis East of closed joint stock company
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