Апротекс – polyvalent inhibitor of proteases of plasma with anti-fibrinolitic, anti-proteolytic, haemo static action.
1 bottle contains:
1 ml of solution contains:
With care it is recommended to appoint Aproteks to patients with allergic reactions in the anamnesis, at the cardiopulmonary shunting operations, a blood circulation stop when carrying out operation using the cardiopulmonary bypass, the deep hypothermia preceding therapy by Aprotininum in case of reception of muscle relaxants in 2-3 days prior to administration of drug, in the II trimester of pregnancy (only according to vital indications).
Lyophilisate and solution enter in/in struyno (slowly, up to 5 ml a minute) or kapelno and intraperitoneally. During Aproteks's use the patient has to be in horizontal position.
For preparation of solution from lyophilisate with a dosage of 10 000 ATRE add 2 ml of isotonic solution of sodium chloride to contents of 1 bottle, with a dosage of 100 000 ATRE – 20 ml.
The recommended daily mode of dosing:
At a pancreatonecrosis with the exudate in an abdominal cavity containing enzymes in addition to in introduction of Aproteks it is possible to appoint intraperitoneally.
Besides, solution of lyophilisate is applied locally at treatment of long insignificant bleedings. For this purpose the gauze napkin impregnated with solution (75 000 ATRE) is put to the place of bleeding.
At disturbances of a hemostasis at children drug is appointed from calculation for 15 000 ATRE to 1 kg of weight of the child a day.
Solution for infusions
The recommended dosing:
At an acute necrosis of a pancreas with a fermental exudate in an abdominal cavity, against the background of in addition enter solution into uses of Aprotininum by the patient intraabdominalno.
Because of big risk of an anaphylaxis Aproteks's use is recommended to be begun after test for hypersensitivity definition. For this purpose the sick 1 ml (10 000 KIE) of Aprotininum needs in/in to enter. At absence within 10 minutes after introduction of a trial dose of signs of allergic reaction it is possible to start introduction of a therapeutic dose, otherwise – use of Aprotininum is forbidden.
In need of purpose of drug patients with the increased risk of development of allergic reactions should enter antihistamines previously. At emergence of symptoms of an allergy introduction of Aprotininum is cancelled immediately. Previous (during from 2 to 24 weeks) therapy by drug increases risk of development of allergic reactions.
At a trombogemorragichesky syndrome drug can be used only after elimination of all disturbances of a blood coagulation against the background of simultaneous preventive purpose of heparin.
Because of risk of development of a renal failure and a lethal outcome with extra care it is necessary to apply Aproteks at a blood circulation stop during operation with use of the cardiopulmonary bypass. When using extracorporal blood circulation in the course of heart operation at the patients receiving high doses of Aprotininum it is necessary to support time of the activated coagulability of blood at the level of higher than 750 seconds. Level of heparin is measured by titrating geparino-prothrombin test.
Influence of drug on ability of the patient to control of vehicles and mechanisms is not established.
Апротекс suppresses action of an urokinase, Streptokinasa, alteplaza and other fibrinolitic means.
Exponentiates effect of heparin, at addition of Aprotininum to a heparinized blood time of coagulation of whole blood increases.
Simultaneous use with drugs of a dextran causes mutual strengthening of action.
Pharmaceutical we will combine only with solutions of electrolytes and Dextrosums.
To protect from children.
To store at a temperature up to 25 °C, lyophilisate – in the place protected from light.
Period of validity: lyophilisate – 3 years, solution – 2 years.
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