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Dextrose

Application instruction:

Form of release and structure

Indications to use

Contraindications

Route of administration and dosage

Side effects

Special instructions

Medicinal interaction

Terms and storage conditions

Dextrose – means of carbohydrate food.

Form of release and structure

Isotonic solution for infusions of 5%: transparent, colourless (on 100 ml in bottles or bottles, in a cardboard pack 1 bottle);
Hypertonic salt solution for infusions of 10%: transparent, colourless (on 100 ml in bottles or bottles, in a cardboard pack 1 bottle).

Active ingredient: a dextrose, in 100 ml of solution – 5 or 10 g.

Excipients: acid solution hydrochloric, water for injections.

Indications to use

Insufficiency of carbohydrate food;
Hypoglycemia;
Toxicoinfection;
Intoxication;
Dehydration (owing to diarrhea, vomiting, in the postoperative period);
Intoxications at liver diseases (hepatitis, an atrophy and dystrophy of a liver, including a liver failure);
Collapse;
Hemorrhagic diathesis;
Shock.

Also the Dextrose is applied to preparation of solutions of medicines for intravenous administration, used as a component of various antishock and blood-substituting liquids.

Contraindications

Absolute:

Fluid lungs;
Overhydratation;
Hyperglycemia;
Giperosmolyarny coma;
Hyper lactacidemia;
Wet brain;
Acute left ventricular failure;
Postoperative disturbances of utilization of glucose;
Hypersensitivity to drug.

Relative:

Hyponatremia;
Dekompensirovanny heart failure;
Diabetes mellitus;
Chronic renal failure (oliguria, anury).

Route of administration and dosage

The dextrose is intended for intravenous administration, drop or jet.

Kapelno 5% enter solution with a speed no more than 7 ml/minute (400 ml an hour) in a daily dose for adults to 2000 ml; 10% solution – with a speed no more than 3 ml/minute in a daily dose for adults to 1000 ml.

By Struyno appoint 10% of solution on 10-50 ml.

At purpose of parenteral food to adult patients with a normal metabolism the most admissible daily dose of the Dextrose makes no more than 4-6 g/kg (i.e. about 250-450 g/days), administer the drug with a speed of 0,25-0,5 g/kg/h. If metabolic rate decreases, the dose is reduced to 200-300 g and entered with a speed of 0,125-0,25 g/kg/h. The daily volume of the liquid entered at the same time has to make 30-40 ml/kg.

To children as parenteral food the Dextrose is entered (on an equal basis with fats and amino acids): in the first day – 6 g/kg/days, further – to 15 g/kg/days. When calculating a dose of drug at introduction of 5% and 10% of solutions it is necessary to consider the admissible daily volume of the entered liquid: children with the body weight of 2-10 kg – 100-165 ml/kg, children weighing 10-40 kg – 45-100 ml/kg. The most admissible rate of administering – 0,75 g/kg/h.

Side effects

Fever;
Disturbance of water and electrolytic balance;
Hypervolemia;
Hyperglycemia;
Acute left ventricular failure;
Local reactions: thrombophlebitis, infection.

Special instructions

Sick diabetes mellitus the dextrose should be entered under control of its content in urine and blood.

For good assimilation of the dextrose entered in high doses insulin at the same time can be appointed: 1 PIECES on 4-5 g of a dextrose.

Medicinal interaction

When the Dextrose is combined with other medicines, it is necessary to control their pharmaceutical compatibility visually.

Terms and storage conditions

To store at a temperature of 5-20 ºС in protected from light, the place, dry, unavailable to children.

Period of validity – 3 years.

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