Drotaverinum

Drotaverinum – the synthetic drug reducing a tone of unstriated muscles of internals and promoting reduction of pain at spasms of various bodies.

Pharmacological action

Active ingredient – Drotaverinum a hydrochloride. Treats spasmolytic drugs of myotropic action. Expands blood vessels and reduces a tone of unstriated muscles of urinogenital and bile-excreting system, bodies of digestive tract and an intestines peristaltics. Improves intake of oxygen in bodies and fabrics.

Has big efficiency and duration of action in comparison with a papaverine to which it is similar in pharmacological action and chemical structure. It is evenly distributed in fabrics and has vazodilatiruyushchy effect.

At oral administration Drotaverinum of the maximum concentration reaches within 45-60 minutes.

Release form

Drug is produced in the form of tablets, tablets, coated and solution for injections.

The tablets Drotaverinum – round, with a facet and risky, flavovirent color. Each tablet contains 40 mg of active ingredient. Excipients: povidone (polyvinylpirrolidone), potato starch, sugar milk, talc and magnesium stearate. On 10 pieces in the blister, on 1, 2, 3, 4 and 5 blisters in cardboard packaging or on 100 pieces in a polymeric can and cardboard packaging.

The tablets Drotaverinum Forte contain 80 mg of active ingredient. On 10 pieces in the blister, on 2 blisters in cardboard packaging.

Solution for injections. 1 ml of solution contains 20 mg of Drotaverinum of a gidlokhlorid. In ampoules on 2 ml, on 5 ampoules in strip packagings, on 2 packagings in a cardboard pack.

Indications to use of Drotaverinum

Use of Drotaverinum is shown for reduction of pain and stopping a spasm of unstriated muscles of digestive tract and urinary and bile-excreting bodies at:

• Pylorospasm;
• Peptic ulcer of a stomach and duodenum;
• Gastroduodenite;
• Spastic locks and renal colitis;
• Proctitis;
• Pyelitis;
• Tenesmus;
• Bilious or intestinal gripes;
• Frustration of bile-excreting system and gall bladder on hyperkinetic type;
• Cholecystitis;
• Postcholecystectomy syndrome.

At treatment of spasms of digestive tract Drotaverinum is applied as a part of a combination therapy.

Also according to the instruction Drotaverinum is effective:

• In gynecology at a dysmenorrhea (painful monthly), threat of an abortion and premature births, puerperal pains;
• For removal of vasospasms at a tensor headache;
• During the carrying out some diagnostic manipulations and tool researches, cholecystography.

Contraindications

According to the instruction Drotaverinum is contraindicated at:

• Hypersensitivity to drug components;
• Inborn lactose intolerance and lactose intolerance (because of existence in structure of Drotaverinum of lactose of a monogidar);
• Heavy heart failure;
• The expressed liver and renal failure.

Drotaverinum is not appointed to children up to 2 years and in the period of a lactation.

With care use drug with the lowered arterial pressure, the expressed atherosclerosis of coronary arteries, closed-angle glaucoma, a prostate hyperplasia, during pregnancy.

Application instruction of Drotaverinum

The pill Drotaverinum is taken orally, without crushing and without chewing. Time of administration of drug does not depend on meal time. Duration of a course is defined individually in each case by the doctor.
The dose of drug depends on age:

• From 2 to 6 years – 10-20 mg to two times a day;
• From 6 to 12 years – 20 mg to two times a day;
• To children 12 years and adult – 40-80 mg 2-3 times a day are more senior. Usually maximum daily dose should not exceed 240 mg.

Solution for injections of Drotaverinum of a hydrochloride is entered intramusculary. Duration and a dose is also calculated individually.

The usual dose for adults makes 2-4 ml from 1 to 3 times a day.

At hepatic or renal gripes perhaps slow intravenous administration. For this purpose 2-4 ml part previously 0,9% with chloride sodium solution.

In rare instances at disturbances of peripheric circulation drug is entered slowly vnutriarterialno.

To teenagers 12 years usually are more senior appoint 1-2 ml of drug 1-3 times a day.

At physiological childbirth to women usually appoint 2 ml of drug intramusculary at the beginning of the period of disclosure of a neck of uterus. If necessary repeatedly enter 2 more ml 2 hours later.

At stomach ulcer and a duodenum Drotaverinum is appointed in a complex with other antiulcerous medicines.

Side effects

Drotaverinum is usually transferred well. Development of some side effects is in rare instances possible:

• Vomiting or nausea;
• Syncope, disturbance of a sleep pattern and wakefulness, development of the increased perspiration, headache;
• Arrhythmia, tachycardia, lowering of arterial pressure or feeling of heat;
• Bronchospasm and insignificant puffiness of a mucous membrane of a nose;
• Itch, Quincke's edema, skin rash, allergic dermatitis.

At intravenous administration of Drotaverinum the lowering of arterial pressure and respiratory depressions is sometimes observed.

Drotaverinum strengthens action of Bendazolum, papaverine and other spasmolysants, and also reduces spazmogenny activity of morphine. At simultaneous use with a levodopa weakens action of the last. In combination with phenobarbital spasmolytic action of Drotaverinum increases.

There are no data on overdose by drug.

Storage conditions

Drotaverinum can be got without medical recipe.

Period of storage of tablets – 3 years, solution for injections – 2 years.