Flutamid interferes Упаковка Флутамид with binding of male sex hormones (androgens) including dihydrotestosterone, with receptors of cells. As a result of it in androgenic and sensitive tumors, for example, in fabrics of tumors of a prostate, there is an obstacle for manifestation of biological effect of androgens. According to reviews Flutamid has no antigestagenny, progestagenny, anti-oestrogenic and oestrogenic activity.

Drug is quickly and well soaked up from the alimentary system. Its maximum concentration in blood is noted two hours later after acceptance inside. The elimination half-life makes five hours. It is removed in the form of metabolites generally by kidneys.

Indications to use

According to the instruction Flutamid is applied to palliative cancer therapy of a prostate with existence of the remote metastasises at patients who did not receive any treatment of this pathology earlier.

According to reviews Flutamid can be used also for treatment of patients at whom it was not succeeded to achieve a positive effect when performing hormonal therapy, and also for those at whom stability (resistance) developed to it.

Drug can be used in a combination with other antineoplastic means or for performing monotherapy.

Instruction

This medicine is appointed on 1 tablet (250 mg) by three times a day. The course of treatment has to be long. During therapy it is necessary to investigate functions of a liver regularly.

With extra care the patients having cardiovascular diseases should appoint Flutamid.

According to the instruction Flutamid can be applied to carrying out differential diagnosis of a hypogonadism at men. In this case drug is appointed at the rate of 10 mg to kg of body weight of the patient a day. It is accepted on three times a day within three days. Then make a concentration research in blood serum of gonadotrophins.

Side effects of Flutamid

Flutamid is usually well had. At long therapy at men the gynecomastia, morbidity in mammary glands, a liquid delay in body tissues can develop. According to reviews Flutamid very seldom causes such complications as a thromboembolism, sleeplessness, a lupoid and similar syndrome, disturbances of functions of a liver and digestive tract, a headache.

In the instruction to Flutamid it is noted: against the background of treatment by it at the patient slight increase in methemoglobin blood (a form of hemoglobin which cannot transfer oxygen) can be observed. This state has passing character and does not demand performing any treatment or Flutamid's cancellation.

Contraindications

Use of this drug is contraindicated for treatment of the patients having a serious illness of a thyroid gland, kidneys and a liver.

Special instructions

Treatment by Flutamid has to be carried out under regular control of activity of liver enzymes. Blood test should be carried out at least once a month. If at the patient increase in level of liver enzymes in two and more times is noted, and/or there is jaundice (provided that there are no metastasises in baking), drug is cancelled at once.

Patients have to see immediately a doctor at the first signs of an abnormal liver function – yellowness of mucous membranes and skin, a skin itch, urine darkening, disgust for food, nausea, vomiting, a grippopodobny syndrome, morbidity in right hypochondrium.

Flutamid's interaction with other medicines

Flutamid strengthens Таблетки Флутамид anticoagulative effect of anticoagulants of indirect action (Flutamin, Varfarin). Therefore at joint purpose of these drugs the dose should be selected individually, under control of a koagulogramma.

Overdose

At Flutamid's overdose it is necessary to wash out a stomach. There is no specific antidote therefore the symptomatic therapy directed to maintenance of zhiznennovazhny functions is carried out.

Form of release of Flutamid

Flutamid is issued in the form of the tablets containing 250 mg of active agent. This medicine is produced also under other names: Норекс, Gibitron, Fulforel, Fugirel, Euleksin, Eufleks, Drogenil, Tsebatrol, Flyutsin, Flutsin.

Storage conditions

Flutamid treats the list B. It is stored at the room temperature in the place, unavailable to children. A period of validity – three years. After the termination of a period of validity drug cannot be used. It is released from drugstores only according to the recipe of the doctor.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Flutamid тбл п / about 250 mg No. 20, Nu-Pharm / Vektor-Medika

574 rub.

To buy

Network of the Moscow drugstores of IFC

Flutamid of a tablet 250 of mg of 84 pieces

1757 rub.

To buy

Apteka вер.ру, LLC

Flutamid тбл п / about 250 mg No. 84, Orion Pharma

1812 rub.

To buy

Network of the Moscow drugstores of IFC

To look at all offers from drugstores

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