Fortum

Fortum – an antibiotic from group of cephalosporins 3 generations.

Pharmacological properties of Fortum

Fortum contains active active ingredient – a ceftazidime. Mechanism of effect of drug bactericidal. It consists in disturbance of formation of a cell wall of microorganisms that causes their death. Fortum is steady against the damaging effect of enzymes of bacteria – beta лактамаз.

The drug action spectrum wide – it perniciously influences on gram-negative (pyocyanic, hemophilic and intestinal sticks, klebsiyella, proteas, enterobakter, tsitrobakter, serration, salmonellas, iyersiniya, neysseriya) and gram-positive (staphylococcus, streptococci), and also anaerobic bacteria (peptokokk, clostridiums, etc.).

According to reviews Fortum is effective concerning the bacteria not sensitive to other types of antibiotics. He does not act on metitsillinrezistentny staphylococcus.

Drug is well soaked up from an injection site in a muscle, is quickly delivered in fabric. Through the unimpaired blood-brain barrier practically does not get into a brain, but in case of an inflammation of a meninx (meningitis) in cerebrospinal fluid therapeutic concentration of an antibiotic are reached. Fortum easily gets through a placenta and into breast milk.

In an organism there is no transformation of Fortum to metabolites. In an invariable look he is brought with urine, about 90% of the administered drug are allocated with kidneys within a day. At a renal failure the speed of removal decreases. It is also important to remember that in connection with features of functioning of an organism of newborns time of semi-removal of drug is slowed down by 3 – 4 times.

Release form

According to the instruction Fortum is released in powder for preparation of solution for injections in bottles on 0,25, 0,5, 1 and 2 g.

Indications to use of Fortum

The antibiotic is appointed at heavy infections which are caused by microorganisms, sensitive to it. It is included into schemes of treatment of sepsis, infectious damages of airways (including complicated a mucoviscidosis), an urinary system, ENT organs, skin and soft tissues, an abdominal cavity, biliary tract, a digestive tract, bone and joint system. Advantage of Fortum is that it helps also at intrahospital infections which are caused by microorganisms with multiple resistance to other antibacterial agents.

Contraindications

Fortum is not applied at intolerance of a ceftazidime, and also other tsefalosporinovy and penicillinic antibiotics.

Application instruction of Fortum

According to the instruction Fortum is entered parenterally into veins or is deep in a muscle. The dose and a course is calculated the attending physician individually, and depends on weight of a state, age, a condition of kidneys. To adults appoint 1 – 6 g/days in 2 – 3 introductions. Standard schemes – on 1 g in 8 hours or on 2 g in 12 hours. The most admissible daily dose for the adult – 6 g, for elderly it should not exceed 3 g.

In cases of the accompanying immunodeficiency and a neutropenia the dose is raised – on 2 g in 8 hours 3 times a day or on 3 g in 12 hours 2 times a day.

For newborns and babies up to 2 months calculation of an antibiotic - 25 – 60 mg/kg/days in 2 introductions.

To children, since age of 2 months, Fortum is calculated on 30 – 100 mg/kg/days in 2 – 3 introductions. At the lowered immunity, a mucoviscidosis and meningitis the dose is raised to 150 mg/kg/days.

For preparation of solution of an antibiotic it is possible to use 0,9% solution of sodium chloride, 5% glucose solution. For introduction in oil Fortum is usually parted by 0,5 or 1% with lidocaine.

At simultaneous use of high doses of Fortum with diuretic and aminoglikozidny antibiotics it is necessary to control function of kidneys.

Side effects of Fortum

According to reviews Fortum sometimes causes hypersensitivity reactions (in the form of urticaria, dermatitis, a Quincke's edema), diarrhea, abdominal pains, vomiting, candidosis damage of mucous membranes, disturbances in work of kidneys, a headache, dizzinesses, spasms, changes in biochemical and general blood test.

Unpleasant complications can be connected with introduction of Fortum parenterally – pain, consolidation and burning in the place of an injection.