Gemaza

Gemaza – fibrinolitic drug for use in ophthalmology.

Form of release and structure

Dosage form – lyophilisate for preparation of solution for injections: the porous mass or amorphous powder of inodorous white color (in glass transparent ampoules with a capacity of 1 or 2 ml, in a blister strip packaging of 5 ampoules, in a cardboard pack 1 packaging).

Active ingredient of Gemaza – a pro-urokinase recombinant, in 1 ampoule – 5000 international units (ME).

Auxiliary components: dextran 40, sodium chloride.

Indications to use

• Fibrinoid syndrome of various etiology;
• Hemophthalmia, hyphema;
• Subretinal, preretinalny and intraretinalny hemorrhages;
• Occlusion of the central artery of a retina, including its branches;
• Thrombosis of the central vein of a retina, including its branches;
• Prevention of formation of commissures after surgery at glaucoma.

Contraindications

• Age up to 18 years;
• Tuberculosis in an active form;
• Pathologies with the increased risk of development of bleeding, including hemorrhagic diathesis;
• Hypertensive crisis (risk of a recurrence of intraocular hemorrhage);
• Gastrointestinal bleedings;
• Proliferative stage of a diabetic retinopathy (III-IV degree);
• Bacterial endocarditis;
• Arterial hypertension (diastolic arterial pressure is more than 105 mm of a mercury column);
• The expressed hepatocellular insufficiency (albumine of blood is less than 3 g/l);
• Chronic renal failure (urea level in blood more than 0,5 g/l, serum creatinine more than 0,02 g/l);
• Period of pregnancy and feeding by a breast;
• Individual hypersensitivity to drug components.

Route of administration and dosage

Gemaza is entered parabulbarno, subkonjyunktivalno, intravitrealno.

Before use it is necessary to part contents of 1 ampoule in 0,9% chloride sodium solution.

For parabulbar or subconjunctival introduction to 1 ampoule of drug add 0,5 ml of 0,9% of solution of sodium of chloride, ready solution corresponds to 5000 ME. Course of treatment no more than 10 injections.

For intravitrealny introduction 1 ampoule of lyophilisate gets divorced in 1 ml of 0,9% of solution of sodium of chloride, then 0,1 ml of the received solution should be parted in 0,1-0,2 ml 0,9% of solution of sodium of chloride, the received dose (0,2-0,3 ml) is entered once.

The dosing mode, the period of treatment is appointed by the doctor.

The route of administration depends on clinical indications:

• The retinal apoplexy or vitreous, occlusal defeat of vessels of an optic nerve and retina – administer the drug parabulbarno;
• Hyphema, existence of an exudate of fibrin after removal of a cataract – parabulbarno, subkonjyunktivalno or in an anterior chamber;
• Hemophthalmia, fibrinoid syndrome of various etiology – intravitrealno;
• Prevention of commissures in the postoperative period – in a filtrational pillow in number of 1-3 injections (introduction should be begun right after operation, using concentration of solution for subconjunctival injections).

Besides, Gemaza is used for washing of an anterior chamber of an eye at a strong exudate of fibrin or a hyphema. For the procedure contents of 1 ampoule dissolve 0,9% of solution of sodium of chloride in 1 ml, then 0,1 or 0,2 ml of the received solution in addition part 0,9% with chloride sodium solution to 0,5 ml.

Side effects

• Perhaps: allergic reaction in the form of hypostasis and a dermahemia of the person on side of a sore eye, inflammatory tenonit allergic genesis (a conjunctiva hyperemia, хемоз, decrease in mobility of an eyeglobe);
• Others: in case of overdose – a recurrence of intraocular hemorrhage.

Special instructions

During Gemaza's use it is recommended to be careful at control of vehicles and mechanisms.

Medicinal interaction

Simultaneous use of drug with injections of a kollalizin is not recommended.

With care it is necessary to combine with other thrombolytic means.

The combination therapy with emoksipiny or dexamethasone is shown.

Terms and storage conditions

To protect from children.

To store at a temperature of 2-20 °C in the place protected from light.

Period of validity – 4 years.