Pyrantelum

General characteristics. Structure:

Active agent - Pyrantelum of an embonat of 720 mg (it is equivalent to Pyrantelum of 250 mg).

Excipients: potato starch, povidone, silicon dioxide colloid, ethyl cellulose, magnesium stearate, orange aroma.

Pharmacological properties:

Pharmacokinetics. Absorption. It is poorly absorbed in digestive tract. Concentration of drug in plasma after reception of a single dose of 10 mg/kg of body weight makes 0,05 – 0,13 mkg/ml within from 1 to 3 hours.

Distribution. Data on penetration of drug through a placenta and in maternal milk, and also about a drug arrangement in biological fabrics and liquids are absent (theoretically absorption of drug is minimum).

Metabolism. The minimum quantity of the drug absorbed in digestive tract partially is metabolized in a liver to N-methyl-1,3-propandiamina (0,8-5,6%).

Removal from an organism. More than 50% of the dose of drug accepted orally are removed in not changed view with excrements and less than 15% with urine in not changed look or in the form of a metabolite N-methyl-1,3-propandiamina.

Pharmacodynamics. Pyrantelum is effective drug at infection intestinal round worms. Affects muscles of intestinal nematodes, by depolarization of their neuromuscular connection and blockade of effect of cholinesterase. Immovable parasites are brought from intestines thanks to the peristaltic movements. Does not cause migration of helminths, does not possess irritant action. Affects mature forms and on parasites in an early stage of development and does not affect larvae during their migration in fabrics. Drug is used first of all at infections with pinworms (Enterobius vermicularis) and ascarids (Ascaris lumbricoides).

It can be applied at infection with an ankylostoma; has more effective effect at treatment of an ankilostomidoz, than at treatment of a necatoriasis.

Indications to use:

- enterobiosis

- ascaridosis

- dochmiasis

- necatoriasis

Route of administration and doses:

Drug is accepted inside, in time or after food, washing down with water.

Before a proglatyvaniye the tablet should be chewed or pounded carefully.

At the diseases caused by Ascaris lumbricoides, Enterobius vermicularis, Ancylostoma duodenale and Necator americanus depending on age and the body weight of the patient the following doses are recommended:

At an ascaridosis and an enterobiosis (and also at a combination of these diseases) the general medical dose (10 mg/kg of body weight) is appointed once.

At an ankilostomidoza the daily dose (10 mg/kg of body weight) is accepted within 3 days once a day. At severe forms of a necatoriasis (massive invasions of Necator americanus) appoint 20 mg/kg of body weight within 2 days once a day.

Features of use:

Pyrantelum should be applied carefully – special medical control is necessary for patients:

- with a liver failure as in the course of treatment drug can increase concentration ASPAT,

- with a hyponutrient or anemia.

Attention:

1. At an enterobiosis it is necessary to carry out simultaneous treatment of all jointly of the living persons.

2. It is necessary to follow the rules of hygiene strictly.

3. After completion of treatment by the drug Pyrantelum Polpharma, in 14 days from the moment of reception, it is necessary to conduct control researches on existence of eggs of parasites.

Controlled researches of safety of use of Pyrantelum at pregnancy were not conducted therefore use of drug during this period is possible only as a last resort when the estimated advantage for mother exceeds potential risk for a fruit.

It is not recommended to appoint to women in the period of a lactation. If treatment by Pyrantelum is extremely necessary, feeding by a breast should be stopped.

In some cases dizziness can be observed, in this regard it is necessary to be careful during driving of vehicles and service of the mechanical equipment.

Side effects:

Side effects pass after the treatment termination.

Seldom (≥1/10 000 to <1/1 000):

- nausea, vomiting, pains and spasms of a stomach, lack of appetite, diarrhea. passing increase in activity of aminotransferases

- headache, dizziness, drowsiness, sleeplessness, weakness,

- skin rash

With an unknown frequency:

- desires on defecation

- hallucinations, disorientation, paresthesia, disorders of hearing

- fever

Interaction with other medicines:

Not to apply along with piperazin. Combined use has antagonistic effect.

Pyrantelum can increase concentration of theophylline in plasma.

Contraindications:

- hypersensitivity to Pyrantelum or excipients

- simultaneous use of piperazin

- myasthenia (treatment period)

Overdose:

Symptoms: vision disorders, a disorientation, dizziness, an unconscious state or dizziness at a rising from a prone position or sitting, the increased perspiration, earlier not observed feeling of fatigue or weakness, irregular pulse; spasms, trembling and weakness of muscles; feeling of exhaustion, asphyxia (suffocation, loss of consciousness).

Treatment: symptomatic and supporting (an early gastric lavage, support of passability of respiratory tracts and breath, support of blood pressure). Specific antidote is absent.

Storage conditions:

To store in the dry, protected from light place, at a temperature below 25 °C.

To store in the place, unavailable to children!

Issue conditions:

According to the recipe

Packaging:

On 3 tablets in planimetric bezjyacheykovy packaging from aluminum foil.

On 1 planimetric bezjyacheykovy packaging together with the application instruction in the state and Russian languages place in a pack from a cardboard.