Гаммалин® (Immunoglobulin against a virus of herpes of simple 1 type of the person)

General characteristics. Structure:

Active ingredients - specific antibodies to a virus of herpes of simple 1 type;
 
excipients - glycine (glycine, the aminoacetic acid), sodium chloride.
 
Main properties: drug is immunological the active protein fraction allocated from serum or the blood plasma of the person cleared and concentrated by a fractionation method alcohol, which passed a stage of a virus inactivation solvent-detergentnym by method. Protein content in 1.0 ml of drug from 0.090 g to 0:11 g. Transparent or slightly opalescent, colourless or yellowish liquid. In the course of storage emergence of an insignificant deposit which disappears when stirring is possible. Drug contains the antibodies to a virus of herpes of simple 1 type determined by an enzyme immunoassay. Drug does not contain preservative and antibiotics, in it there are no antibodies to VICh-1, VICh-2, a virus of hepatitis C and a surface antigen of a virus of hepatitis B.

Pharmacological properties:

The operating basis of drug are immunoglobulins, in particular the immunoglobulin G specific to a virus of herpes of simple 1 type. Specific activity of drug is caused by virus neutralizing action of antibodies. Besides, immunoglobulin G causes immunomodulatory effect, influencing different links of immune system of the person, and increases nonspecific resistance of an organism.

Indications to use:

Drug is used for the purpose of treatment of the diseases caused by a virus of herpes of simple 1 type including: encephalitis, encephalomyelitis, meningoentsefalit, arakhnoentsefalit, arachnoidites, entsefalopoliradikulit, etc.

Route of administration and doses:

Immunoglobulin is entered intramusculary.

For treatment of diseases of the adults called by a virus of herpes of simple 1 type, including defeats of a nervous system, immunoglobulin is entered by 5 times with a two-daily interval in a dose of 4.5 ml (3 ampoules on 1.5 ml) on introduction.

Features of use:

It is forbidden to administer the drug intravenously!

Use during pregnancy and feeding by a breast. Long-term clinical experience of use of immunoglobulin indicates that it is not necessary to expect any harmful effects on mother and a fruit at pregnancy or on the newborn.
 
Immunoglobulin is emitted with breast milk and therefore can promote transfer of protective antibodys from mother to the child.

Side effects:

Reactions to administration of immunoglobulin, as a rule, are absent. In rare instances there can be local reactions in the form of a hyperemia and temperature increase to 37.5 °C within the first days. Drug with the changed reactivity can cause reactions of an allergy of different type in individuals, and in exclusively exceptional cases - an acute anaphylaxis. In this regard persons who received drug have to be under medical observation within 30 minutes.

Interaction with other medicines:

The combination with other antiherpetic drugs (an acyclovir, zovirax, герпевир) just before use of immunoglobulin or at the same time within 5 - 10 days on 0.2 g of 5 times a day is possible.

Contraindications:

Administration of immunoglobulin is contraindicated to the persons having heavy allergic reactions to introduction of proteinaceous blood preparations of the person in the anamnesis. And in the next 3 days antihistaminic drugs are recommended to the patients having allergic diseases or having them in the anamnesis in day of administration of immunoglobulin. To the persons suffering from immune general diseases (diseases of blood, connecting fabric, nephrite, etc.), it is necessary to enter immunoglobulin against the background of the corresponding therapy.

Overdose:

It was not studied.

Storage conditions:

In the dry, protected from light place at a temperature from 2 °C to 8 °C. To store in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Liquid on 1.5 ml or 3.0 ml in ampoules, on 5 or 10 ampoules in a box with a corrugated insert or with a polymeric insert from a film polyvinyl chloride for placement and fixing of ampoules.