MAO inhibitors

MAO inhibitors – the antidepressants applied at treatment of parkinsonism and a narcolepsy.

Pharmacological effect of MAO inhibitors

MAO inhibitors classify by pharmacological properties on the non-selective irreversible, reversible selection and irreversible selection.

The MAO non-selective irreversible inhibitors on chemical structure are close to Iproniazidums, improve the general condition of patients with a depression and reduce stenocardia attacks.

The MAO reversible selection inhibitors have antidepressive and psychoenergizing effect, actively suppress deamination of serotonin and noradrenaline.

The MAO irreversible selection inhibitors have protivoparkinsonichesky effect, participate in metabolism of dopamine and catecholamines.

List of drugs of MAO inhibitors

Are included in the list of MAO inhibitors of non-selective irreversible:

• Fenelzin;
• Iproniazidum;
• Isocarboxazid;
• Nialamidum;
• Tranylcyprominum.

Carry to the MAO irreversible selection inhibitors Selegilin.

Are included in the list of MAO inhibitors of the reversible selection:

• Metralindol;
• Pirlindol;
• Befol;
• Moklobemid;
• Derivatives beta карболинов.

Indications to use of MAO inhibitors

Drugs MAO inhibitors non-selective irreversible appoint at treatment of an alcoholism and depressions (neurotic, involutional and cyclotymic), reversible the selection – at depressions of various genesis, a depressive syndrome, a melancholic syndrome and astenoadinamichesky frustration, and irreversible the selection – at treatment of a disease of Parkinson.

Contraindications

Reception of MAO inhibitors of the reversible selection is contraindicated at:

• Hypersensitivity;
• Acute inflammatory diseases of kidneys and liver;
• Abstinence alcoholic syndrome;
• Pregnancies and in the period of a lactation.

Also MAO inhibitors reversible the selection do not appoint drugs at infantile age.

Reception of MAO inhibitors non-selective irreversible is not appointed at:

• Hypersensitivity;
• Liver failure;
• Disturbance of cerebral circulation;
• Chronic renal failure;
• Chronic heart failure.

Reception of MAO inhibitors of the irreversible selection is contraindicated at:

• Pregnancies and in the period of a lactation;
• Reception of other antidepressants;
• Hypersensitivity;
• Essential tremor;
• To chorea of Gentington.

With care MAO inhibitors irreversible the selection appoint drugs at:

• The progressing dementia;
• Late dyskinesia;
• Heavy psychosis;
• To round ulcer of digestive tract;
• Prostate hyperplasia;
• Heavy stenocardia;
• To closed-angle glaucoma;
• Krupnorazmashisty tremor;
• Tachycardias;
• To pheochromocytoma;
• Diffusion toxic craw.

Side effects

Use of the MAO reversible selection inhibitors can cause:

• Uneasiness;
• Dryness in a mouth;
• Headache;
• Sleeplessness.

Use of the MAO non-selective irreversible inhibitors can cause:

• Dyspepsia;
• Lowering of arterial pressure;
• Uneasiness;
• Sleeplessness;
• Headache;
• Dryness in a mouth;
• Locks.

Use of the MAO irreversible selection inhibitors can cause complications from various systems of an organism, namely:

• Loss of appetite, dryness of a mucous membrane of an oral cavity, increase in activity of transaminases, nausea, diarrhea, locks and dysphagy (alimentary system);
• Increased fatigue, sleeplessness, dizzinesses, hallucinations, headache, uneasiness, dyskinesia, motive and hyperphrenia, confusion of consciousness and psychoses (nervous system);
• Increase in arterial pressure, orthostatic hypotension and arrhythmia (cardiovascular system);
• Diplopia and disturbances of visual acuity (sense bodys);
• Nocturia, ischuria and painful desires on an urination (urinary system);
• Asthma, photosensitization, skin rash and bronchospasm (allergic reactions).

Also reception of the MAO irreversible selection inhibitors can cause perspiration, a hypoglycemia and a hair loss.