Ergocalciferol

Ergocalciferol - means for the prevention and treatment of a hypovitaminosis and avitaminosis of D.

Pharmacological properties

Ergocalciferol (D2 vitamin) participates in regulation of phosphorus-calcium exchange in an organism. Under the influence of organism enzymes it turns into the active metabolites capable it is easy to get into cells through membranes and to contact in them specific receptors. Such interaction of Ergocalciferol with receptors activates synthesis of the protein connecting calcium, and also collagen, enzyme of an alkaline phosphatase, etc. Absorption of calcium and phosphorus from intestines in blood is facilitated, their moving to various bodies, and, first of all, in a bone tissue accelerates.

D2 vitamin stimulates growth of cartilaginous tissue in growth zones of bones, and in kidneys strengthens the return absorption of calcium, phosphates, amino acids. On the action mechanism Ergocalciferol is an antagonist of parathormone of epithelial body.

From a digestive tract Ergocalciferol is soaked up in distal department of a small intestine, extent of absorption depends on its shortage level in an organism, making 60 – 90%, and bile strengthens absorption. It turns into active metabolites in a liver and kidneys, most longer in an organism remains in fatty tissue. Removal from an organism is carried out through intestines.

Release form

Drug is produced in a dragee, oil and spirit solution for the internal use, in drops for intake.

Indications to Ergocalciferol use

Inside Ergocalciferol is applied to prevention and treatment of deficit of calcium and phosphorus in an organism at such states as rickets and rakhitopodobny diseases, osteoporosis, a softening of a bone tissue, disturbance of absorption of calcium and phosphorus in intestines, at a lack of a sunlight in the conditions of Far North, alcoholism, during pregnancy and feeding by a breast, at a hypoparathyrosis, a pseudohypoparathyroidism, a tetany.

Outwardly use D2 vitamin for treatment of dermatitis with dry skin, a diaper dermatitis, burns of easy degree, small wounds and cuts, grazes, for the prevention of education and treatment of cracks on nipples at the nursing women.

Contraindications

According to the instruction Ergocalciferol is not applied at intolerance of D2 vitamin, excess content of calcium and phosphorus in an organism, at a renal osteodystrophy. Carefully under observation of the doctor it is used at an active pulmonary tuberculosis, a sarcoidosis, at elderly people, at pregnancy at women 35 years, when feeding by a breast, formation of phosphatic stones in case of an urolithiasis are aged more senior, than chronic renal and heart failure.

Application instruction of Ergocalciferol

For the internal use the dose is selected individually depending on disease severity and taking into account that amount of vitamin which arrives with food. Before use it is desirable to mix drug in a spoon with a small amount of water.

For the prevention of development of rickets in children its prevention is carried out, appointing Ergocalciferol to women, since 30 weeks of pregnancy, during the autumn and winter period. The dose makes 400 – 500 ME a day daily.

At the full-term children for the purpose of prevention according to the instruction 3 – 4 weeks, in a dose of 400 - 500 ME/days within the first 2 years of life give Ergocalciferol during the autumn and winter period, since age. In summer months drug is not shown. For premature children, and also in unsuccessful conditions and at low degree of insolation preventive reception is begun with 2 week age, in a dose of 1000 ME/days. This technique received the name of a method of "fractional doses".

For the children who are on artificial feeding by the adapted mixes when calculating a daily dose of Ergocalciferol it is necessary to consider its content in mix and to properly reduce a drug dosage.

To carry out prevention of rickets by method of "vitamin pushes", Ergocalciferol 2 times a week from 6 to 8 weeks in a row give in a dose 20 – 30 thousand ME.

For separate categories of children – from socially dysfunctional families or the closed institutions, in northern regions of residence, with risk factors of development of rickets against the background of associated diseases for its prevention it is more convenient to use "the condensed method" when the daily dose of Ergocalciferol makes 10 – 15 thousand ME a day 20 days in a row.

For treatment of rickets of a dose of Ergocalciferol is higher. At 1 degree of rickets recommend to the full-term children reception of D2 vitamin from 10 to 15 thousand ME/days, at the 2nd degree – the general course dose makes 600 – 800 thousand ME, at the 3rd stage of 700 - 800 thousand ME on a course. Duration of reception depends on sharpness of a current – at an acute current the course dose is distributed for 10 – 15 days, at subacute for 30 – 45 days of reception.

In case of osteomalacy and osteoporosis Ergocalciferol is accepted for 3000 ME every day within 1,5 months, reception of 400 - 800 ME/days together with calcium drugs is necessary for women in the period of a menopause. At pathology of epithelial bodies the dose of Ergocalciferol can reach 1 million ME a day.

At treatment by this means for prevention possible its time in 7 days needs to be defined by Sulkovich's test the content of calcium in urine.

D2 vitamin needs to be stored in densely closed packaging in the dark place that its medicinal properties did not lose the force. In an organism this fat-soluble drug can collect.

When reception of high doses of Ergocalciferol is required, with it optimum to accept a complex of vitamins A, In and Page. The bigger effect at premature children requires a concomitant use of phosphates.

For external use Ergocalciferol is applied on clean skin by 2 times a day, duration of use depends on dynamics of a disease.

Side effects of Ergocalciferol

According to the instruction Ergocalciferol can cause headaches, weakness, nausea, an acrimony, frequent urinations, weight reduction, calcification of fabrics, is very rare – disturbances of a cordial rhythm.