Contrykal

Contrykal – the medicine having haemo static and anti-proteolytic effect.

Form of release and structure

Contrykal is produced in the form of lyophilisate for preparation of solution for intravenous and intracavitary administration (in bottles, in blister strip packagings on 5 bottles, on 1 or 2 packagings in a cardboard pack complete with solvent (isotonic solution of sodium of chloride) in ampoules on 2 ml).

Is a part of 1 bottle:

• Active ingredient: Aprotininum – 10 000 ATRE (anti-tryptic units, 1 ATRE there correspond 1,33 kallikrein to the inactivating units (KIU));
• Auxiliary component: Mannitolum.

Indications to use

• Depressed cases;
• Acute pancreatitis;
• The heavy hemorrhagic complications connected with performing thrombolytic therapy;
• The bleedings caused by a hyper fibrinolysis: postoperative, posttraumatic, arising before, in time and after the delivery;
• Postoperative pancreatitis (prevention).

Contraindications

• First trimester of pregnancy;
• Hypersensitivity to drug components.

In need of Contrykal use by women in the period of a lactation it is necessary to consider a question of breastfeeding interruption.

Route of administration and dosage

Contrykal is entered intravenously struyno, in situation "lying" (slowly, with the maximum speed up to 5 ml a minute), or kapelno (it is long or it is short). Patients with the exudate containing enzymes and an acute necrosis of a pancreas can enter solution intraperitoneally.

Before Contrykal use contents of 1 bottle should be dissolved in 2 ml of isotonic solution of sodium of chloride.

As a rule, apply the following modes of dosing:

• Acute pancreatitis: slowly intravenously 200 000-300 000 ATRE, further for 24 hours kapelno intravenously enter the same dose. Therapy is continued before normalization of a clinical picture of a disease and indicators of laboratory analyses;
• Bleedings: slowly intravenously 300 000 ATRE, then with a break 4 hours on 140 000 ATRE;
• Depressed cases: slowly intravenously on 200 000-300 000 ATRE, then with a break 4 hours on 140 000 ATRE;
• Prevention of development of a fatty embolism and postoperative pancreatitis: slowly intravenously on 200 000 ATRE a day (as auxiliary treatment).

To children solution of Contrykal is entered on 14 000 ATRE/kg a day.

Side effects

During use of Contrykal there can be following side effects:

• Alimentary system: vomiting, nausea;
• Cardiovascular system: tachycardia, arterial hypotension;
• Allergic reactions: symptoms of anaphylactic reactions (sometimes up to development of an acute anaphylaxis), skin rash (after repeated introductions);
• Local reactions: thrombophlebitis (after long drop injections).

Special instructions

For definition of individual sensitivity to effect of drug, before use of Contrykal it is recommended to carry out skin tests.

Patients with high risk of emergence of allergic reactions before administration of solution should administer the antihistaminic drugs. At development of allergic reactions and emergence of signs of shock, therapy needs to be interrupted at once.

At treatment of heavy anaphylactic reactions together with carrying out the standard measures for rendering acute management it is necessary to enter immediately intravenously adrenaline in a dose of 0,05-0,1 mg (in need cases adrenaline is entered repeatedly). Besides apply high doses of glucocorticosteroids (for example, 250-1000 mg of Prednisolonum) and plasma substitutes.

Contrykal should not be applied along with a beta laktamnymi antibiotics.

Patients with the IDCS can apply Contrykal solution only after elimination of all symptoms of a disease and against the background of preventive use of heparin.

Medicinal interaction

At simultaneous use Contrykal lowers activity of an urokinase and Streptokinasa.

Terms and storage conditions

To store in protected from light, the place, unavailable to children, at a temperature up to 25 °C.

Period of validity – 3 years.