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Lactulose

Сироп ЛактулозаLactulose – a purgative with osmotic properties.

Form of release and structure

Dosage form – syrup (on 200, 500 or 1000 ml in plastic bottles, in a cardboard pack 1 bottle complete with a measured glass).

Active ingredient of drug – lactulose, in 1 ml – 667 mg.

Auxiliary components: the citric acid, water purified.

Indications to use

  • Lock, including at hemorrhoids, pregnancy or chronic;
  • Training of the patient for surgery on a large intestine;
  • The rehabilitation period after surgical intervention in the field of an anus and/or on a large intestine;
  • Softening of fecal masses for simplification of defecation at pains after removal of hemorrhoidal nodes;
  • Hepatic coma and prekoma;
  • Hepatic encephalopathy.

Contraindications

  • Rectal bleedings;
  • Hereditary diseases: deficit of lactase, lactose intolerance, glyukozo-galaktozny malabsorption, galactosemia;
  • Kolostoma or ileostoma;
  • Impassability of intestines;
  • Suspicion of appendicitis;
  • Hypersensitivity to lactulose.

With care appoint drug to patients with a diabetes mellitus, a gastrocardial syndrome.

Route of administration and dosage

Lactulose is accepted inside, at desire syrup can be dissolved with water or juice.

The daily dose and the period of treatment is appointed by the doctor on the basis of clinical indications.

The recommended dosing:

  • Locks: an initial dose for adult patients – on 15-45 ml the first 3 days, supporting – 10-25 ml; an initial dose for children at the age of 7-14 years – on 15 ml, supporting – 10 ml. An initial and maintenance dose of syrup for children aged: 1-6 years – 5-10 ml; from 1,5 months to 1 year – 5 ml. It is necessary to accept drug 1 time a day during a breakfast;
  • Hepatic encephalopathy: on 30-50 ml 2-3 times a day, for achievement of clinical effect are possible increase to 190 ml a day. For the purpose of prevention of development of a hepatic coma by the patient with the expressed damage of a liver appoint 25 ml of syrup 3 times a day;
  • Salmonellosis: on 15 ml 3 times a day, the reception period – 10-12 days. After a break (7 days) the course should be repeated. Carrying out a third year of treatment in a dose of 30 ml 3 times a day is in case of need possible.

Side effects

Use of Lactulose can cause undesirable effects:

  • Alimentary system: perhaps – a meteorism (usually in an initiation of treatment, further gradually passes), pain in a stomach, diarrhea, disturbance of water and electrolytic balance (at reception of high doses); seldom – nausea;
  • Nervous system: seldom – dizziness, a headache, spasms;
  • Others: perhaps – development of allergic reactions; seldom – weakness, a mialgiya, arrhythmia, increased fatigue.

Special instructions

During pregnancy and breastfeeding use of syrup according to clinical indications is possible.

It is impossible to use drug without establishment of the exact diagnosis at feeling of nausea, abdominal pains or vomiting.

Not to allow development of a meteorism in patients with a gastrocardial syndrome initial dosing has to be lower recommended, it needs to be raised gradually, bringing to therapeutic effective dose.

When developing diarrhea reception of Lactulose should be cancelled.

Especially carefully use drug at inflammatory damages of a large intestine at patients with a diabetes mellitus.

At the patients accepting drug more than 6 months it is regularly recommended to control the level of content of potassium, carbon dioxide and chlorine in a blood plasma.

Medicinal interaction

Antibiotics of a broad spectrum of activity can reduce clinical effect of drug. Effect of lactulose reduces рН intestines contents therefore at a concomitant use with kishechnorastvorimy medicines with рН dependent release release of their active agents can be broken.

Terms and storage conditions

To store in the unavailable to children and protected from light place at a temperature from 5 to 25 °C.

Period of validity – 2 years.

 
 
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