Neotone

Neotone – the drug promoting improvement of metabolism of muscular tissue and a myocardium.

Form of release and structure

Neotone is released in the form of powder for preparation of solution for infusions: granules of white color (in bottles on 1 g, on 1 or 4 bottles in a cardboard pack).

Active agent is a part of 1 bottle: phosphocreatinine sodium tetrahydrate – 1 g.

Indications to use

Neotone is appointed as a part of the combined treatment of such diseases as:

• Acute myocardial infarction;
• Heart failure (chronic current);
• Intraoperative ischemia of a myocardium and lower extremities.

In sports medicine Neoton apply to prevention of development of a syndrome of a physical overstrain (chronic and acute), and also for the purpose of improvement of adaptation of athletes to excessive exercise stresses.

Contraindications

• Chronic renal failure (for a daily dose of 5-10 g);
• Age up to 18 years (efficiency and safety of use of Neoton for this age group of patients are not established);
• Hypersensitivity to drug components.

To pregnant women Neoton appoint only in cases when the advantage for mother is higher than estimated harm for a fruit. During a lactation for the period of therapy it is necessary to interrupt breastfeeding.

Route of administration and dosage

Neotone is entered only intravenously kapelno or in the form of bystry infusion.

The mode of dosing will be defined by indications:

• Acute myocardial infarction: 0-24 hours – intravenous bystry infusion of 2-4 g of Neoton divorced in water for injections of 0,05 l with the subsequent intravenous infusion for 2 hours 8-16 g in 0,2 l of 5% of solution of glucose (dextrose); during second day 2 times a day intravenously kapelno (infusion duration – of 30 minutes) enter 2-4 g of the drug divorced in 0,05 l of water for injections; during third day the drug is administered according to the same scheme in a dose 2 g (if necessary treatment is continued for 6 days);
• Heart failure (chronic current): therapy can be begun with shock doses – on 5-10 g of Neoton in 0,2 l of 5% of solution of glucose (dextrose) intravenously kapelno with a speed of 4-5 g an hour for 3-5 days; further drug is used in maintenance doses – intravenously kapelno (infusion duration – of 30 minutes) 1-2 g of the drug divorced in 0,05 l of water for injections with frequency rate of introduction 2 times a day for 2-6 weeks. If the condition of the patient allows, treatment is begun with use of maintenance doses according to the stated above scheme at once;
• Intraoperative ischemia of a myocardium: intravenously kapelno (infusion duration – of 30 minutes) 2 g of the drug divorced in 0,05 l of water for injections with frequency rate of introduction 2 times a day. The course is begun in 3-5 days prior to surgical intervention and continued 1-2 more days after its carrying out. During operation Neoton it is necessary to add to composition of usual cardioplegic solution in concentration 10 mmol/l or 2,5 g/l just before introduction;
• Intraoperative ischemia of the lower extremities: to surgical intervention – bystry infusion of 2-4 g of drug in 0,05 l of water for injections; during operation and in the period of reperfusion – intravenously kapelno 8-10 g of Neoton in 0,2 l of 5% of solution of glucose (dextrose) with a speed of 4-5 g/h.

In sports medicine, according to indications to use, Neoton appoint intravenously kapelno (infusion duration – of 30 minutes) 1 g a day in 0,05 l of water for injections, course duration – 3-4 weeks.

Side effects

• Cardiovascular system: lowering of arterial pressure (at bystry intravenous administration);
• Allergic reactions: manifestations of hypersensitivity to active agent of Neoton.

Special instructions

At ischemia for providing more favorable forecast Neoton it is necessary to enter into the shortest terms from the moment of emergence of symptoms of a disease.

Use of high daily doses of drug (5-10 g) is followed by the increased capture of phosphates in kidneys that influences calcic exchange, secretion of the hormones regulating a homeostasis, exchange of purines and function of kidneys therefore long therapy of Neoton in high doses is not recommended.

Medicinal interaction

Drug keeps stability in cardioplegic solutions, water for injections and solution of 5% of glucose (dextrose).

At simultaneous use Neoton promotes increase in efficiency of drugs with positive inotropic action and anti-anginal, antiarrhytmic means.

Terms and storage conditions

To store in the place, unavailable to children, at a temperature up to 30 °C.

Period of validity – 3 years.