Panavir

Panavir – the medicine having antiviral and immunomodulatory effect.

Form of release and structure

Panavir release in the following dosage forms:

• Suppositories rectal: from white with a yellowish shade till white color, a cylindrical or cone-shaped form, inodorous; existence of yellowish-gray impregnations is allowed (in blister strip packagings on 5 pieces, on 1 or 2 packagings in a cardboard pack);
• Suppositories vaginal: translucent, grayish-white, a cylindrical or cone-shaped form (in blister strip packagings on 5 pieces, on 1 packaging in a cardboard pack);
• Gel for external and topical administration: white, homogeneous, has a slight specific smell (in aluminum tubas with an internal varnish covering on 3, 5, 10 or 30 g, on 1 tuba in a cardboard pack);
• Solution for intravenous (in/in) introductions: slightly opalescent or transparent, with a light brown shade or colourless, inodorous (in the neutral glass ampoules or bottles corked by traffic jams from rubber with a running in aluminum caps on 5 ml, on 2 or 5 ampoules or bottles in blister strip packagings, on 1 or 2 packagings in a cardboard pack (for ampoules – complete with an ampoule knife or the scarificator, or without it)).

Active agent – the purified extract of escapes Solanum tuberosum – the hexose glycoside consisting of uronic acids, rhamnose, glucose, a galactose, pectine sugar, xyloses, mannoses (Panavir).

Composition of 1 rectal suppository:

• Active agent: Panavir – 0,2 mg;
• Additional components: paraffin – 90 mg, solid or confectionery fat – 1019,8 mg, T-2 emulsifier – 90 mg.

Composition of 1 vaginal suppository:

• Active agent: Panavir – 0,2 mg;
• Additional components: a macrogoal of 1500 (poly(ethylene oxide) 1500) – 1259,9 mg, a macrogoal 400 (poly(ethylene oxide) 400) – 139,9 mg.

Structure of 10 mg of gel for external and topical administration:

• Active agent: Panavir – 0,0002 mg;
• Additional components: 95% ethanol – 0,1 mg, sodium hydroxide of-0,04 mg, hexahydrate of lanthanum nitrate – 0,22 mg, a macrogoal of 4000 - 1,5 mg, a macrogoal of 400 - 3,8 mg, глицерол – 3 mg, water – to 10 mg.

Structure of 1 bottle or ampoule of solution for in/in introductions:

• Active agent: Panavir – 0,2 mg;
• Additional components: sodium chloride – 45 mg, water for injections – to 5 ml.

Indications to use

Rectal suppositories

• Cytomegaloviral infection, including usual not incubation of pregnancy (Panavir's use is possible during preparation for pregnancy at women with an interferonodefitsitny state and a persistent viral infection);
• Flu and acute respiratory viral infections (in combination with other drugs);
• The infections caused by a virus of a herpes simplex of various localization including herpes a zoster, офтальмогерпес, recurrent genital herpes;
• Anogenitalny warts (human papillomavirus infections) (in combination with other drugs);
• The secondary immunodeficiency which developed against the background of infectious diseases;
• Tick-borne encephalitis (in combination with other drugs for reduction of virus loading and expressiveness of the neurologic symptomatology which is shown as an anizorefleksiya, decrease in reflexes, a nystagmus, morbidity of points of an exit of cranial nerves).

Vaginal suppositories
The indication to use is genital herpes at women (in combination with other drugs).

Gel
It is shown to use at infectious and inflammatory diseases of mucous membranes and/or the skin caused by a virus of a herpes simplex of types I and II including genital herpes.

Solution for in/in introductions

• The secondary immunodeficiency which developed against the background of infectious diseases;
• The infections caused by a virus of a herpes simplex of various localization including herpes a zoster, офтальмогерпес, recurrent genital herpes;
• Flu and acute respiratory viral infections (in combination with other drugs);
• Anogenitalny warts (human papillomavirus infection) (in combination with other drugs);
• Cytomegaloviral infections, including usual not incubation of pregnancy (Panavir's use is possible during preparation for pregnancy at women with an interferonodefitsitny state and a persistent viral infection);
• Peptic ulcer of a stomach and duodenum at it is long not cicatrizing ulcers and symptomatic ulcers of a gastroduodenal zone (in combination with other drugs);
• The pseudorheumatism which is followed by a herpesviridae infection at immunokomprometirovanny patients (in combination with other drugs for strengthening of anesthetic and antiinflammatory effect of the main therapy);
• Chronic bacterial prostatitis (in combination with other drugs);
• Tick-borne encephalitis (in combination with other drugs for decrease in virus loading and expressiveness of neurologic symptomatology, the shown anizorefleksiya, a nystagmus, decrease in reflexes, morbidity of points of an exit of cranial nerves).

Contraindications

• Serious illness of kidneys and a spleen (for vaginal suppositories);
• Age up to 12 years (for solution for in/in introductions) or 18 years (for other dosage forms of production of drug);
• Pregnancy (for vaginal and rectal suppositories; for solution for in/in introductions – Panavir's appointment is possible only after advantage ratio assessment with risk for health of the woman and a fruit, except for use of drug in the II-III trimester as a part of complex treatment at an exacerbation of a persistent Cytomegaloviral infection; for gel – appointment is possible only after advantage ratio assessment with risk for health of the woman and a fruit);
• Lactation period;
• Hypersensitivity to drug components.

Route of administration and dosage

Rectal suppositories
Route of administration – rektalno.

The scheme of use (1 suppository – a single dose):

• Flu and acute respiratory viral infections: 5 doses with an interval of 24 hours;
• Cytomegaloviral and human papillomavirus infections: the first week – 3 doses with an interval of 48 hours, the second week – 2 doses with an interval of 72 hours;
• Herpesviridae infections and tick-borne encephalitis: 2 doses with an interval of 24 or 48 hours. In 30 days repetition of a course is possible.

Vaginal suppositories
Route of administration – intravaginalno, in the evening. Candles should be entered as it is possible more deeply (in a dorsal decubitus with slightly bent legs).

Panavir enter daily a course of 5 days on 1 suppository. The doctor can appoint a repeated medical course.

Gel
Drug should be applied with a thin layer on affected areas of skin and/or mucous membranes.

The recommended dosing mode:

• The infectious and inflammatory diseases of mucous membranes and/or skin caused by a virus of a herpes simplex of types I and II (including genital herpes): 5 times a day a course of 4-5 days (extension up to 10 days is possible);
• Human papillomavirus infections: 2 times a day a course lasting 15 days (5 days to and 10 days after carrying out laser removal of condylomas).

Solution for in/in introductions
Route of administration – intravenously struyno slowly.

Single adult dose – 0,2 mg of active ingredient (contents of 1 bottle or an ampoule).

The recommended scheme of use of Panavir for adults:

• Cytomegaloviral and human papillomavirus infections: the first week – 3 doses with an interval of 48 hours, the second week – 2 doses with an interval of 72 hours;
• Tick-borne encephalitis and herpesviridae infections: 2 doses with an interval of 24 or 48 hours. In 1 month the medical course can be repeated;
• The pseudorheumatism proceeding with a herpesviridae infection at immunokomprometirovanny patients: 5 doses with an interval of 24-48 hours, repetition of a course are possible in 2 months;
• Peptic ulcer of a stomach and duodenum (aggravation), symptomatic ulcers of a gastroduodenal zone: 5 doses with an interval of 48 hours;
• Bacterial chronic prostatitis: 5 doses with an interval of 48 hours;
• Flu and acute respiratory viral infections: 2 doses with an interval of 18-24 hours.

To children of 12 years Panavir appoint 0,1 mg once a day.

The recommended dosing mode:

• Cytomegaloviral and human papillomavirus infections: the first week – 3 doses with an interval of 48 hours, the second week – 2 doses with an interval of 72 hours;
• Tick-borne encephalitis and herpesviridae infections: 2 doses with an interval of 24 or 48 hours, are possible repetition of a course in 1 month.

Side effects

Vaginal suppositories
Development of allergic reactions is possible.

In case of any undesirable disturbances, it is necessary to interrupt therapy and to consult at the specialist.

Gel
In a site of application of Panavir it can be observed short-term reddening and an itch of skin and/or mucous membranes.

Rectal suppositories, solution for in/in introductions
Drug is, as a rule, transferred by patients well.

Possible disturbances can be connected with hypersensitivity to Panavir's components.

Special instructions

Vaginal suppositories
For the purpose of prevention of development of urogenital reinfection, performing simultaneous therapy of sexual partners is recommended. In the absence of effect or insufficient efficiency of Panavir it is necessary to confirm the diagnosis.

Gel
It is recommended to begin treatment at early stages of a disease, at emergence of the first symptoms, such as an itch, reddening, a pricking, feeling of tension. In this case it is possible to prevent emergence of a bubble stage of a disease.

Panavir in ophthalmology is not applied.

When putting gel on area of the person it is necessary to avoid its hit in eyes.

Solution for in/in introductions
At Cytomegaloviral and herpesviridae infections Panavir's use during preparation for pregnancy promotes decrease in frequency of reproductive losses.

Administration of the dimmed solution is forbidden.

Medicinal interaction

Significant interaction of Panavir with other medicines was not registered.

Terms and storage conditions

To store in protected from light, the place, dry, unavailable to children.

Period of validity:

• Rectal suppositories – 3 years at a temperature of 2-8 °C;
• Vaginal suppositories, gel – 3 years at a temperature of 2-25 °C;
• Solution for in/in introductions – 5 years at a temperature of 2-25 °C.