Parlazin

Parlazin – the drug having antiallergic effect.

Form of release and structure

Dosage forms of release of Parlazin:

• Drops for intake: almost colourless or colourless, without deposit, have a slight characteristic smell of acetic acid (on 20 ml in dark glass bottles droppers, on 1 bottle dropper in a cardboard pack);
• Tablets, film coated: biconvex, with a facet, light orange, oblong, inodorous; on one party – risk, on another – an engraving "Е 511"; on a break: a periblast – light orange, a kernel – white or almost white (on 5 or 7 pieces in blisters, on 1 blister in a cardboard pack; on 10 pieces in blisters, on 1 or 3 blisters in a cardboard pack).

Structure of 10 ml of peroral drops:

• Active agent: цетиризин (in the form of dihydrochloride) – 100 mg;
• Auxiliary components: пропилпарагидроксибензоат – 1,5 mg, propylene glycol – 3500 mg, acetic ice acid – 5 mg, глицерол – 2500 mg, sodium saccharinate – 100 mg, methylparahydroxybenzoate – 13,5 mg, sodium acetate trihydrate – 100 mg, the purified water – to 10 ml.

Structure of 1 tablet:

• Active agent: цетиризин (in the form of dihydrochloride) – 10 mg;
• Auxiliary components and cover: anhydrous colloid silicon dioxide – 0,8 mg, magnesium stearate – 1,7 mg, monohydrate of lactose – 11,5 mg, microcrystallic cellulose – 91 mg, Opadry Y-1-7000 (a macrogoal 400, a gipromelloza, titanium dioxide (C.I.77891)) – 4 mg, yellow dye a sunset (yellow sanst ariavit (C.I.15985)) – 0,01 mg.

Indications to use

• Quincke's disease;
• Seasonal and year-round allergic rhinitis and conjunctivitis;
• Pruritic allergic dermatosis;
• Seasonal allergic rinokonjyunktivit;
• Small tortoiseshell (including chronic idiopathic).

Contraindications

Absolute:

• Renal failure (clearance of creatinine <10 ml a minute);
• Syndrome of disturbance of absorption of a galactose glucose and lactose intolerance (for tablets);
• Age till 1 year (for peroral drops) or 6 years (for tablets);
• Period of pregnancy and lactation;
• Hypersensitivity to drug components.

Relative (Parlazin appoint with care after dose adjustment in the presence of the following states / diseases):

• Renal failure in a chronic current of average and heavy degree;
• Advanced age.

Route of administration and dosage

Tablets and drops Parlazin accept inside. Before reception of a drop it is necessary to mix with a small volume of water.

The recommended scheme of use of drug (10 mg of active ingredient contain in 1 tablet or 20 drops):

• Children 1-2 years (drop): 5 mg in 2 receptions;
• Children of 2-6 years (drop): 5 mg in 1 or 2 receptions;
• Children of 6-12 years (tablet or drop): 10 mg in 1 or 2 receptions;
• Adults and children of 12 years (a tablet or a drop): 10 mg in 1 reception.

Drug should be accepted daily. At frequency rate of reception once a day – drug is more preferable to accept in the evening, 2 times a day – in equal parts in the morning and in the evening.

Dose adjustment can be required by elderly patients.

At functional disturbances of kidneys the dose is defined by clearance of creatinine:

• ≥50 ml/min. (normal function of kidneys and easy disturbances): 10 mg in 1 reception;
• 30-49 ml/min. (moderate disturbances): 5 mg in 1 reception;
• 11-29 ml/min. (heavy disturbances): 5 mg in 1 reception every other day;
• ≤10 ml/min. (hemodialysis): Parlazin do not appoint.

Formula for definition of value of the clearance of creatinine (CC):

KK = body weight (in kg)/72 × [140 - age (advanced in years)] - blood serum creatinine (in mg/dl).

For women the received KK value is multiplied on 0,85.

Side effects

Parlazin in most cases is had by patients without development of side effects. Development of such disturbances as is in certain cases possible:

• Allergic reactions: hypersensitivity up to development of an acute anaphylaxis;
• Hemopoietic system: thrombocytopenia;
• Respiratory system: inflammation of a mucous membrane of a throat (pharyngitis) and nasal cavities (rhinitis);
• Alimentary system: nausea, diarrhea, dryness of a mucous membrane of an oral cavity, pain in a stomach, an abnormal liver function (increase in activity of hepatic transaminases, an alkaline phosphatase, gamma глутамилтрансферазы, concentration of bilirubin);
• Nervous system: hallucinations, tic, dizziness, drowsiness, headache, excitement, tremor, aggression, confusion of consciousness, depression, faint, sleeplessness, spasms, dyskinesia of biliary tract, dystonia, paresthesias;
• Cardiovascular system: tachycardia;
• Urinary system: dysuria, urine incontience;
• Sight: disturbance of accommodation and visual perception, involuntary oscillating motions of eyes (nystagmus);
• Hypodermic cellulose and skin: itch, rash, urticaria, Quincke's disease;
• Others: adynamy, indisposition, fatigue, hypostases, increase in weight.

Special instructions

At development of reactions of hypersensitivity Parlazin cancel.

At patients with functional disturbances of kidneys active ingredient can collect in an organism. It even in cases of administration of drug in therapeutic doses can lead to increase in weight and frequency of collateral anticholinergic disturbances or impact on the central nervous system. For this group of patients administration of drug in the lowered doses is recommended.

Parlazin's reception needs to be interrupted not later, than in 3 days before performance of a skin allergy test (because of probability of obtaining false-negative results).

To anticholinergic action of Parlazin (in the form of an ischuria, dryness in a mouth) special sensitivity is shown by elderly patients. If these disturbances are observed the long period, and also in cases of increase in their intensity, treatment needs to be interrupted.

During Parlazin's reception by the patient it is recommended to be careful at control of vehicles, and also performance of other potentially dangerous works at which bystry psychomotor reactions and high concentration of attention are required.

Medicinal interaction

Interaction with Cimetidinum, ketokonazoly, diazepam, erythromycin, azithromycin and pseudoephedrine was not revealed.

During treatment it is impossible to take alcohol.

At the combined use of a tsetirizin from 400 mg of theophylline a day reduction of the general clearance of Parlazin is observed (without changes of kinetics of theophylline).

Simultaneous use with antibiotic drugs from group of macroleads and ketokonazoly does not cause clinically significant changes on the electrocardiogram.

Terms and storage conditions

To store in protected from light, the place, unavailable to children, at a temperature up to 25 °C.

Period of validity – 4 years.

It is possible to store drops after opening of a bottle dropper not longer than 30 days.