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Alkaptonuria (alcaptomiria; alkapton – homogentistic acid (an intermediate product of exchange of phenylalanine and tyrosine) + Greek uron – urine) – the hereditary disease caused by disturbance of exchange of tyrosine because of hypoactivity of enzyme of a gomogentizinaza and accumulation of gomotentizinovy acid in body tissues. At adults the alkaptonuria is shown by development of arthroses, pigmentation of various fabrics, in children – only dark coloring of urine, in certain cases – an earwax. The disease is inherited on autosomal recessively type.

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