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Thiamin

Application instruction:

Pharmacological action

Release form

Indications to use

Contraindications

Application instruction

Side effects

Thiamin is a water-soluble B1 vitamin which is applied to completion of its deficit in an organism, and also to treatment of a number of diseases. Капсулы Тиамин

Pharmacological effect of Thiamin

In an organism Thiamin turns into a coenzyme cocarboxylase. It is a part of many enzymes catalyzing biochemical reactions. By means of cocarboxylase vitamin plays an important role in carbohydrate, proteinaceous and a lipometabolism. Regulating thus a metabolism, it exerts positive impact on all organism at different pathological processes.

Feature of Thiamin is its ability to influence carrying out nervous excitement in synapses, improving it. It is possible because of change of polarization of membranes in neuromuscular connection thanks to what moderate ganglioblokiruyushchy effect is had. B1 vitamin is also capable to protect cells from destruction by oxygen radicals, that is shows antioxidant properties.

Drug after hit in blood widely spreads in fabrics, its about a half gets into muscles. Removal is carried out with a stake and urine. As vitamin water-soluble, it is not capable to collect in an organism and is quickly removed.

Release form

Thiamin according to the instruction is produced in the form of solution for injections, capsules and tablets.

Indications to Thiamin use

Thiamin according to the instruction is applied to completion in an organism of its deficit at the increased need for it, insufficient receipt or excess loss, and also to treatment of some diseases.

Insufficient content of Thiamin is called B1 hypovitaminosis, and its total absence – B1 avitaminosis (a beriberi disease).

Drug is included into schemes of treatment of diseases of a nervous system - neuritis, polyneurites, radiculitises, peripheral paresis and paralyzes, neuralgia.

In dermatology B1 vitamin is applied at a neurogenic dermatosis, a skin itch, pyodermas, psoriasis, eczema.

Thiamin received good comments in complex treatment of diseases of the alimentary system – a peptic ulcer of a stomach and a duodenum, an atony of intestines, liver diseases.

At a long physical and mental overstrain, during pregnancy and feeding by a breast, at patients on a hemodialysis the need for B1 vitamin sharply increases, and demands completion from the outside.

Contraindications

Thiamin according to the instruction is not appointed at its intolerance if it was registered earlier.

Application instruction of Thiamin

Ways of administration of drug different – inside and parenterally (intramusculary, subcutaneously, intravenously). Раствор для инъекций Тиамин

For intake in the form of Thiamini chloridum the adult dosage makes 10 mg of 1 - 3 time a day, to children 3 years – on 5 mg every other day, aged from 3 up to 8 years – on 5 mg 3 times a day in a day, a course of 30 days are younger.

In need of more bystry saturation of an organism as Thiamin choose a parenteral way of introduction. The drug is administered 1 time a day, the adult on 1 ml, children on 0,5 ml, the course makes from 10 to 30 injections. Because of a low rn parenteral injections are painful.

It is impossible to enter at the same time parenterally B1, B6 and B12 vitamins – it will reduce their medicinal action and will increase probability of allergic reaction. Use of Thiamin and niacin in one syringe is impossible.

Side effects

According to reviews Thiamin is well transferred, but is sometimes capable to cause allergic reactions in the form of a small tortoiseshell, a Quincke's edema, a skin itch, is very rare – an acute anaphylaxis. At parenteral administration of reaction are stronger, than at intake. Also perspiration and increase of heartbeat meet.

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