Арбидол®

General characteristics. Structure:

Active agent: метилфенилтиометилдиметиламинометил-гидроксиброминдол carboxylic acid of ethyl ether of a hydrochloride monohydrate (arbidol) in terms of anhydrous substance - 50 mg or 100 mg.
Excipients: potato starch, cellulose microcrystallic, silicon dioxide colloid (aerosil), povidone (коллидон 25), calcium стефарат.

Gelatinous solid capsules:
titanium dioxide (Е 171), quinolinic yellow (Е 104), dye sunset yellow (Е 110), methylparahydroxybenzoate, пропилпарагидроксибензоат, acetic acid, gelatin.

Or gelatinous solid capsules:
titanium dioxide (Е 171), quinolinic yellow (Е 104), dye sunset yellow (Е 110), gelatin.

Description:
Dosage of 50 mg - capsules No. 3 of yellow color; a dosage of 100 mg - capsules No. 1 of white color, a lid of yellow color. Contents of capsules - the mix containing granules and powder from color, white to white with a greenish-yellowish or creamy shade.

Pharmacological properties:

Pharmacodynamics. Antiviral means. Specifically suppresses influenza viruses And yes In, the coronavirus associated with the heavy acute respiratory syndrome (HARS). On the mechanism of antiviral action treats fusion inhibitors (fuziya), interacts with hemagglutinin of a virus and interferes with merge of a lipidic viral envelope and cellular membranes. Has moderate immunomodulatory effect. Has interferonindutsiruyushchy activity, stimulates humoral and cellular reactions of immunity, phagocytal function of macrophages, increases resistance of an organism to viral infections. Reduces the frequency of development of the complications connected with a viral infection and also exacerbations of chronic bacterial diseases.

The therapeutic effectiveness at viral infections is shown in decrease in expressiveness of the general intoxication and the clinical phenomena, reduction of duration of a disease.

Treats low-toxic drugs (_LD50> of 4 g/kg). Does not make any negative impact on a human body at oral administration in the recommended doses.

Pharmacokinetics. It is quickly absorbed and distributed on bodies and fabrics. The maximum concentration in a blood plasma at reception in a dose of 50 mg is reached in 1,2 h, in a dose of 100 mg – in 1,5 h. It is metabolized in a liver. The elimination half-life is equal 17-21 h. About 40% are removed in not changed look, generally with bile (38,9%) and in insignificant quantity kidneys (0,12%). Within the first days 90% of the entered dose are removed.

Indications to use:

Prevention and treatment at adults and children:

• flu A and B, SARS, the heavy acute respiratory syndrome (HARS) (including complicated by bronchitis, pneumonia);
• secondary immunodeficiency;
• complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection.
• Prevention of postoperative infectious complications and normalization of the immune status.
  Complex therapy of acute intestinal infections of a rotavirusny etiology at children is more senior than 3 years.

Route of administration and doses:

Inside, before meal. Single dose: to children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, are more senior than 12 years and adult – 200 mg (2 capsules on 100 mg or 4 capsules on 50 mg).

For nonspecific prevention:

1. At direct contact with patients with flu and other SARS:
   to children from 3 to 6 years - 50 mg, from 6 to 12 years – 100 mg, are more senior than 12 years and adult – 200 mg within 10-14 days once a day.
2. In the period of a flu epidemic and other SARS, for the prevention of exacerbations of chronic bronchitis, a recurrence of a herpes infection:
   to children from 3 to 6 years - 50 mg, from 6 to 12 years – 100 mg, are more senior than 12 years and adult - 200 mg two times a week within 3 weeks.
3. For prevention the TORSO (at contact with the patient):
   to adults and children 12 years are more senior appoint 200 mg once a day. Children are from 6 to 12 years old on 100 mg once a day (to food) within 12-14 days.
4. Prevention of postoperative complications:
   to children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, are more senior than 12 years and adult – 200 mg in 2 days prior to operation, then for the 2 and 5 days after operation.

For treatment.

1. Flu, other SARS without complications:
   to children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, are more senior than 12 years and adult – 200 mg 4 times a day (each 6 hours) within 5 days.
2. Flu, other SARS with development of complications (bronchitis, pneumonia, etc.):
   to children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, are more senior than 12 years and adult – 200 mg 4 times a day (each 6 hours) within 5 days, then a single dose within 4 weeks once a week.
3. Heavy Acute Respiratory Syndrome (HARS):
   to children 12 years and adult – 200 mg 2 times a day within 8-10 days are more senior.
4. In complex treatment of chronic bronchitis, a herpes infection:
   to children from 3 to 6 years – 50 mg, from 6 to 12 years – 100 mg, are more senior than 12 years and adult – 200 mg 4 times a day (each 6 hours) within 5-7 days, then a single dose 2 times a week within 4 weeks.
5. Complex therapy of acute intestinal infections of a rotavirusny etiology at children is more senior than 3 years:
   from 3 to 6 years – 50 mg, from 6 to 12 years-100 of mg, are more senior than 12 years – 200 mg 4 times a day (each 6 hours) within 5 days.

Features of use:

Does not show the central neurotropic activity and it can be applied in medical practice in the preventive purposes at almost healthy faces of various professions including requiring special attention and coordination of movements (drivers of transport, operators, etc.).

Side effects:

Seldom - allergic reactions.

Interaction with other medicines:

At appointment with other medicines of negative effects it was not noted.

Contraindications:

Hypersensitivity to drug, age up to 3 years.

Overdose:

It is noted.

Storage conditions:

List B. To store in the dry place protected from light at ^{a temperature not higher than 25 ° C}.
To store in the places unavailable to children.

Period of validity: 2 years. Not to use after the period of validity specified on packaging.

Issue conditions:

Without recipe

Packaging:

Capsules of 50 mg and 100 mg.
On 5 or 10 capsules in a blister strip packaging. 1, 2 or 4 planimetric packagings with the application instruction in a pack from a cardboard.