Heparin Plus

General characteristics. Structure:

Active ingredient: 2500 ME heparins (in the form of heparin sodium), 1 g of benzocaine, 0,2 g of a benzilnikotinat in 1 tube.

Excipients - glycerin, white soft paraffin, stearic acid, corn oil, emulsifier composition (wax emulsion and emulsifier No. 1), methylparahydroxybenzoate (Е 218), пропилпарагидроксибензоат (Е 216), the water purified.

Pharmacological properties:

Pharmacodynamics. The combined drug for external use which action is caused by properties of the components which are its part. Anticoagulant of direct action. The heparin which is gradually released from ointment sodium reduces inflammatory process and has antitrombotichesky effect.

Promotes a rassasyvaniye of already available and interferes with formation of new blood clots. Blocks thrombin synthesis, reduces aggregation of thrombocytes. Activity of hyaluronidase oppresses, activates fibrinolitic properties of blood. Local anesthetic benzocaine reduces expressiveness of pain. When drawing has local analgeziruyushchy effect on skin.

Pharmacokinetics. Heparin is slightly soaked up from the surface of skin. Communication with proteins of plasma - to 95%, distribution volume - 0,06 l/kg. Does not get through a placenta and into breast milk. It is intensively taken endothelial cells and cells of mononuklearno-macrophagic system, concentrates in a liver and a spleen. It is metabolized in a liver with participation of N-desulfamidazy and haparinase of thrombocytes joining in metabolism of heparin at later stages.

Desulfatirovanny molecules under the influence of endoglycosidase of kidneys turn into low-molecular fragments. The period to a floor of removal (T1/2) - 1-6 h (on average - 1,5 h); increases at obesity, a liver and/or renal failure; decreases at a thromboembolism of a pulmonary artery, infections, malignant tumors. It is removed by kidneys, it is preferential in the form of inactive metabolites. It is not removed by means of a hemodialysis. Benzilnikotinat gets into all layers of skin. Practically does not come to a system blood stream. Benzocaine at external use is practically not absorbed.

Indications to use:

- thrombophlebitis of superficial veins;
- superficial periphlebitis;
- hypodermic hematoma;
- post-injection and post-infusional phlebitis;
- hypostasis and bruise as a result of injuries and bruises of soft tissues (not earlier, than in a day after an injury);
- outside hemorrhoids.

Route of administration and doses:

Outwardly. Ointment inflict a thin layer on area defeats (at the rate of 0,5-1 g on the site with a diameter of 3-5 cm) and carefully rub in skin 2-3 times a day daily before disappearance of the inflammatory phenomena, on average from 3 to 7 days. The possibility of carrying out longer course of treatment is defined by the doctor.

At fibrinferment of outside hemorrhoidal nodes apply rectal tampons, apply ointment on byazevy or linen laying which is imposed directly on the thrombosed nodes and fixed. Ointment should be applied daily, before disappearance of symptoms, on average, from 3 to 10 days. With the same purpose it is possible to use the tampon impregnated with ointment which is entered into an anus.

Features of use:

It is not necessary to apply on open wounds, in the presence of purulent processes. Use of ointment is not recommended at deep venous thrombosis.

At use of local forms of heparin (including ointments) the risk of development heparin - the induced immune thrombocytopenia of the II type with decrease in quantity of thrombocytes <100.000 x 109/l or <50% of initial level with development of arterial or venous thrombosis is not excluded. For prevention of this complication it is necessary to control the level of thrombocytes at patients with thrombosis episodes in the anamnesis. The maximum risk of development of this complication is observed for 6-14 day after an initiation of treatment.    Due to a possibility of systemic action, it is necessary to use Unguentum Heparini with care. At patients with hypersensitivity to heparin thrombocytopenia can develop within several hours.

The patients having tromboembolic episodes in the anamnesis should appoint Unguentum Heparini, with care, in connection with a possibility of its systemic action. For the purpose of differential diagnosis heparin - the induced thrombocytopenia of the II type is recommended to define quantity of thrombocytes in blood.

Influence on ability to manage vehicles and to work with mechanisms. Drug does not exert adverse impact on ability to manage vehicles and to work with mechanisms.

Use at pregnancy and feeding by a breast. Safety of use of drug at pregnancy and in the period of a lactation is not established. Heparin does not pass through a placental barrier and is not emitted with breast milk. There are no data on hit of other components of drug in breast milk. Unguentum Heparini is applied at pregnancy and in the period of a lactation (breastfeeding) only if the estimated advantage for mother exceeds potential risk for a fruit or the child.

Use for children. Drug is contraindicated to children till 1 year.

Side effects:

Dermahemia, allergic reactions.

Metilparagidroksibenzoat and пропилпарагидроксибензоат can cause allergic reactions of the slowed-down type. Benzilnikotinat can cause burning sensation.

Interaction with other medicines:

Ointment is not appointed along with non-steroidal anti-inflammatory drugs (NPVP), tetracyclines, H1 blockers - histamine receptors.

At co-administration of anticoagulants and dezagregant (for example, warfarin, acetylsalicylic acid, Dipiridamolum, Streptokinasa) strengthening of anticoagulative effect of heparin is possible.

Contraindications:

Hypersensitivity to drug components.

Existence at the moment or in the anamnesis of geparinindutsirovanny thrombocytopenia of the II type. Hypocoagulation.

Bleeding in the place of alleged putting ointment, disturbance of integrity of integuments of the struck area (open contaminated wounds, ulcer and necrotic processes in particular).

Children till 1 year.

Overdose:

Due to the insignificant system absorption the overdose is improbable.

Storage conditions:

At a temperature from 8 °C to 15 °C. To store in the place, unavailable to children. A period of validity - 2 years. Not to use medicine after the termination of a period of validity.

Issue conditions:

Without recipe

Packaging:

On 25 g in tubas aluminum. Each tuba together with a leaf an insert on a medical use is located in a pack from a cardboard.