Contrykal

General characteristics. Structure:

One bottle contains:
Active agent: 10 000 ATRE (anti-tryptic units) of active agent of Aprotininum received from lungs of cattle.

Excipient: Mannitolum.

One ampoule with solvent contains 2 ml of isotonic solution of sodium chloride.

Pharmacological properties:

Pharmacological action - haemo static, anti-proteolytic. Inhibits many proteases, including plasmin, and brakes a fibrinolysis.

Indications to use:

- Acute pancreatitis
- Prevention of postoperative pancreatitis and fatty embolism
- Bleedings and hemorrhages owing to giperfibrinoliza: posttraumatic, postoperative; to, later and at the time of delivery; heavy gemmoragicheskiye complications during thrombolytic therapy
- Shock states.

Route of administration and doses:

Without doctor's instructions for Contrykal the following modes of doses are valid:

At acute pancreatitis: to immediately intravenously (slowly) sick enter 200 000 — 300 000 ATRE of Contrykal, then within 24 hours intravenously kapelno still enter 200 000 — 300 000 ATRE of Contrykal.

This treatment is carried out up to normalization of a clinical picture of a disease and indicators of laboratory analyses.

Prevention of postoperative pancreatitis: slowly intravenously Contrykal is entered in a dose of 200 000 ATRE in days as auxiliary treatment.

For treatment of depressed cases: in the beginning slowly intravenously Contrykal is entered in a dose of 200 000 — 300 000 ATRE, then in a dose of 140 00 ATRE every 4 hour.

Prevention of a fatty embolism: in the beginning slowly intravenously Contrykal is entered in a dose of 200 000 ATRE, then daily slowly intravenously enter about 200 000 ATRE of Contrykal as auxiliary treatment.

At bleedings: in the beginning slowly intravenously Contrykal is entered in a dose of 300 000 ATRE, then every 4 hour slowly intravenously Contrykal is entered in a dose of 140 000 ATRE.

To children Contrykal is entered in a daily dose of 14 000 ATRE on body weight kg.

Route of administration

 

Contents of 1 bottle are dissolved in 2 ml of isotonic solution of sodium of chloride.

This solution is entered to the patient in a prone position intravenously struyno (slowly, at most 5 ml 1 minute) whether or by short long drop infusion. The patient with the acute necrosis of a pancreas and an exudate in an abdominal cavity containing enzymes, it is possible to enter Contrykal in addition intraperitoneally.

Features of use:

In a case of development of allergic reaction and emergence of symptoms of shock administration of Contrykal should be stopped immediately.

If necessary, in such cases carry out the standard measures for elimination of these complications as, for example, one - or reusable intravenous administration of adrenaline in a dose of 0,05 — 0,1 mg, intravenous administration of Prednisolonum in a dose of 250 — 1000 mg and administration of plasma substitutes.

Side effects:

Are possible, more possibly after repeated introductions, skin rash, symptoms of anaphylactic reactions up to development of an acute anaphylaxis. Besides, tachycardia, nausea, vomiting, arterial hypotension, pallor of integuments, an asthma, plentiful sweating are possible.

Interaction with other medicines:

Contrykal reduces activity of Streptokinasa and urokinase.

Whenever possible Contrykal should not be combined with other medicines, especially with β-laktamny antibiotics.

Contraindications:

It is not necessary to appoint Contrykal the patient with hypersensitivity to Aprotininum. At patients with the increased tendency to supersensitive reactions or hypersensitivity to medicines Contrykal is applied only carefully.

In the first 3 months of pregnancy Contrykal is not applied.

Storage conditions:

Period of validity 3 years. List B.: At a temperature not above 25 °C. Medicine is stored in the place, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

On 10 bottles in a set with 10 ampoules of solvent in packaging.