Hyper fibrinolysis
Contents:
Description:
The hyper fibrinolysis is an activation of fibrinolitic system of blood. Distinguish primary and secondary hyper fibrinolysis.
Giperfibrinoliz's symptoms:
The state owing to excess activation of a fibrinolysis can develop at various diseases and morbid conditions which can be divided into the following main groups: a) the increased allocation in a blood stream of activators (a fabric plasminogen activator, as we know, the fabric plasminogen activator is produced by an endothelium, a mesothelium, monocytes, megacaryocytes, malignant cells, and also contains in a myocardium, a prostate gland, a uterus, a liver, a placenta. The increased allocation in blood of a fabric plasminogen activator is observed at a prostate cancer (the raised products of an urokinase), cancer of a liver and other her diseases, a promiyelotsitarny leukosis, operations on easy and other parenchymatous bodies, the heavy course of sepsis and other states; b) disturbance of clearance of activators of a fibrinolysis (at liver diseases); c) excess local allocation of plasminogen activators pathology, including defeat of a placenta; etc.); Diagnosis of diseases of system of blood of) secondary activation of a fibrinolysis owing to lytic therapy (use of drugs of Ouro and others a state owing to the fibrinolysis broken ingib is observed preferential at a syndrome of the disseminated blood coagulation and liver diseases (at severe damage of a liver synthesis in plasmin inhibitor hepatocytes as a result of operation of the above-stated mechanisms at a rinoliza is broken content in plasma of plasmin which has high activity and leads to splitting of peptide bonds in fibrin, fibrinogen increases, destroys factors of coagulation of V, VIII, X, IX, a factor the background activates a complement. Finally sharp increase in level of plasmin in blood leads to development of heavy bleedings. It is promoted also by emergence during a fibrinolysis of a large number of products of degradation of fibrin which have effect, slow down aggregation of thrombocytes and a blood coagulation.
Giperfibrinoliz's reasons:
Primary гиперфибринолйз is the primary activation of fibrinolitic system which is not reflecting reaction of an organism to the increased formation of fibrin. The secondary hyper fibrinolysis is an activation of fibrinolitic system on the increased formation of fibrin in an organism.
Giperfibrinoliz's treatment:
For correction of activity of fibrinolitic system of blood such drugs as an alfarona, Ambenum, ascorbic acid, биавен use, dexamethasone, никомед, Dexasonum, etamsylate, heparin, etc.
