Aminocapronic acid on 1 g No. 2х5

General characteristics. Structure:

Active ingredient: aminocaproic acid; 1 package contains aminocapronic acid 1 g.

Pharmacological properties:

The specific styptic means applied at the bleedings caused by increase in a fibrinolysis. The mechanism of specific action is caused by competitive oppression of plasminogen activators and partial oppression of activity of plasmin (in high doses), and also inhibition of biogenic polypeptides – kinin. The activating action of Streptokinasa, urokinase and fabric kinases on processes of a fibrinolysis oppresses, neutralizes effects of kallikrein, trypsin and hyaluronidase, reduces permeability of capillaries.

Aminocapronic acid has  antiallergenic, antiviral effect, strengthens detoksitsiruyushchy function of a liver. It inhibits the proteolytic activity associated with an influenza virus. Aminocapronic acid exerts the braking impact on different stages of interaction of a virus with sensory cells, and also proteolytic processing of hemagglutinin oppresses. Thereof the functional and active protein of an influenza virus providing its infectious activity is not formed and the quantity of a docherny infectious virus decreases. Aminocapronic acid not only shows antiviral activity, and also improves some cellular and humoral indicators of specific protection of an organism at respiratory viral infections. After intake it is quickly soaked up in upper parts of digestive tract. The maximum concentration in blood at adults and teenagers is reached in 2 – 3 hours. Practically does not contact blood proteins. Partially (10 – 15%) it biotransformirutsya in a liver; other part is removed by kidneys preferential in not changed look. Per day about 60% of the entered dose (are brought out of an organism at normal function of kidneys).

At disturbance of urinary function drug cumulation is possible.

Indications to use:

Prevention and treatment of parenchymatous bleedings, hemorrhages from mucous membranes, menorrhagias, bleedings from erosion and stomach ulcers and intestines. Prevention of bleedings at liver, lungs, pancreas operations. Different types of a hyper fibrinolysis, including connected using thrombolytic drugs and massive transfusion of stored blood. As symptomatic means – bleeding caused by thrombocytopenia and qualitative inferiority of thrombocytes (dysfunctional thrombocytopenia). Treatment and prevention  of flu and SARS at children and adults.

Route of administration and doses:

Appoint inside, in time or after food, having dissolved powder in sweet water or washing down with it. The daily dose for adults is divided into 3 – 6 receptions, for children – into 3 – 5 receptions.

Moderately expressed increase in fibrinolitic activity. The adult usually appoint 5 – 24 g (5 – 24 packages) in a daily dose.

For children aged till 1 year the single dose makes 0,05 g/kg of body weight (but no more than 1 g). A daily dose for children: aged till 1 year makes – 3 g (3 packages), 2 – 6 years – 3 – 6 g (3 – 6 packages), 7 – 10 years – 6 – 9 g (6 – 9 packages). For teenagers the maximum daily dose – 10 – 15 g (10 – 15 packages).

Acute bleedings (including gastrointestinal). Adult appoint 5 g (5 packages), then 1 g (1 package) each hour (within no more than 8 hours) to a full stop of bleeding. A daily dose for children at acute blood losses: aged till 1 year – 6 g (6 packages), 2 – 4 years – 6 – 9 g (6 – 9 packages), 5 – 8 years – 9 – 12 g (9 – 12 packages), 9 – 10 years – 18 g (18 packages).

Subarachnoidal hemorrhage. The adult appoint 6 – 9 g (6 – 9 packages) in a daily dose.

Traumatic hyphema. Appoint in a dose 0,1 g/kg of body weight each 4 hours (but no more   

24 g/days) within 5 days.

The metrorrhagias associated with intrauterine means. Appoint 3 g

(3 packages) every 6th hour.

Prevention and stop of bleeding at dental interventions. The adult appoint 2 – 3 g (2 - 3 packages) of 3 - 5 times a day.

For adults the average daily dose makes – 10 – 18 g (10 – 18 packages), the maximum daily dose – 24 g (24 packages). A course of treatment - 3 – 14 days.

Flu, acute respiratory viral infections at children and adults.

Drug is used orally and locally. For oral administration drug is previously dissolved at the rate of 1 g (1 package) of aminocapronic acid in two tablespoons  of the sweetened boiled water, receiving thus 5% solution. Orally drug is appointed in doses:

- to children of the first two years of life - 1-2 g (1-2 packages) a day (20-40 ml of 5% of solution) – on 1-2 teaspoons 4 times a day (0,02-0,04 g/kg – a single dose), it is possible to add to food or drinks;

- to children at the age of 2-6 years - 2-4 g (2-4 packages) a day (40-80 ml of 5% of solution) – 1-2 tablespoons 4 times a day;

- to children at the age of 7-10 years - 4-5 g (4-5 packages) a day,   washing down with water, or accept with food or drinks;

- to teenagers and adult –5-8 g (5-8 packages) a day – on 1-2 packages of 4-5 times a day, washing down with water, or accept with food or drinks.

For more exact preparation of solution and its dosing it is reasonable to use the medical syringe without needle of 10 or 20 ml.

 Use of aminocapronic acid locally is at the same time recommended. Each 3 hours to put serially in each nasal course for 5-10 minutes wadded turundas, plentifully moistened 5% the solution of aminocapronic acid prepared on not sweetened water or in the specified terms to instillirovat (to drip) on 3-5 drops of this solution in each nasal course. Solution can be also applied to inhalations.

At severe hypertoxical forms of flu or SARS of a dose of drug can be increased to level maximum,   recommended for children at moderately expressed increase in fibrinolitic activity.

At treatment of flu and SARS at adults drug of aminocapronic acid can be used in such doses, as for teenagers. Aminocapronic acid if necessary can be applied in a combination with other  antiviral drugs (Amizon, "Tamiflu", etc.) both interferon and its inductors.

It is reasonable to carry out intranasal instillations of solution of aminocapronic acid (3-4 times a day) throughout the epidemic   period for the purpose of prevention that it is possible  to add peroral (as at treatment) with use of drug in the infection centers at contact with the patient.

Duration of oral administration of aminocapronic acid at flu and a SARS makes 3-7 days.

Duration of treatment depends on disease severity and is defined by the doctor individually. Also the doctor can adjust a dose and to appoint a repeated course of treatment.

Features of use:

With care appoint at heart diseases, a liver and/or renal failure. Use of drug at a hamaturia is not recommended (in connection with danger of development of an acute renal failure). At prolonged use (more than 6 days) of high doses (more than 24 g a day for adults) emergence of hemorrhages owing to braking of aggregation and adhesion of thrombocytes is possible. At menorrhagias reception from the first to the last day monthly is effective. During therapy drug recommends check of fibrinolitic activity of blood and level of fibrinogen.

Use during pregnancy or feeding by a breast. Drug is contraindicated at pregnancy. Use for women for the purpose of prevention of the raised blood loss at childbirth since emergence of tromboembolic episodes is possible is inexpedient. In need of use in the period of a lactation feeding by a breast should be stopped.

Ability to influence speed of response at control of motor transport or work with other mechanisms. During treatment it is necessary to abstain from control of motor transport and performance of potentially dangerous types of activity owing to possible side reactions (dizziness, etc.).

Children. Children of the first year of life can use drug.

Side effects:

From cardiovascular system: orthostatic hypotension, subendocardial hemorrhage, bradycardia, arrhythmias.

From the alimentary system: nausea, diarrhea.

From system of a blood coagulation: at prolonged use (more than 6 days) of high doses (for adults – more than 24 g a day) – hemorrhages.

From the central nervous system: headache, dizziness, sonitus, spasms.

Others: catarral phenomena of upper parts of respiratory tracts, skin rash, myoglobinuria, рабдомиолиз, acute renal failure.

By-effects are rare and dozozavisimy; at a dose decline they usually disappear.

Interaction with other medicines:

At intake it is well combined with thrombin. The effect of drug is weakened by antiagregant and anticoagulants of direct and indirect action. Combined use with estrogensoderzhashchy contraceptives, blood-coagulation factors of IX increases risk of thromboembolisms.

Contraindications:

The increased individual sensitivity to aminocapronic acid, tendency to fibrinferments and embolisms, all hereditary and secondary thrombophilias, a syndrome of the disseminated intravascular coagulation, a gross hematuria, heavy renal failures, pregnancy, the feeding period a breast.

Overdose:

Symptoms: strengthening of by-effects, formation of blood clots, embolisms. At prolonged use development of opposite effect – a hemorrhage is possible. Treatment: drug withdrawal, symptomatic therapy.

Storage conditions:

To store in the dry place at a temperature from 8 °C up to 25 to °s.khranit in the place, unavailable to children.

Period of validity. 2 years.

Issue conditions:

Without recipe

Packaging:

On 1 g of powder in packages No. 1 or in the packages coupled No. 2, or in packages of the coupled No. 4 (No. 2х2), No. 10 (2x5) in a cardboard box.