Aminocapronic acid of 5%

General characteristics. Structure:

Active ingredient: 5 g of aminocapronic acid, 0,9 g of sodium of chloride.

Excipients: water for injections.

Aminocapronic acid has antiallergenic effect, strengthens detoksitsiruyushchy function of a liver, antibodyformation oppresses.

Pharmacological properties:

Pharmacodynamics. Aminocapronic acid belongs to synthetic analogs of a lysine. It inhibits a fibrinolysis, competitively sating the lysineconnecting receptors thanks to which plasminogen (плазмнн) contacts fibrinogen (fibrin). Drug also inhibits biogenic polypeptides (slows down the activating action of Streptokinasa, urogeinaza, fabric kinases (on a fibrinolysis), neutralizes effects of kallikrein, trypsin and hyaluronidase, (reduces permeability of capillaries.

The pharmacokinetics At intravenous administration action is shown in 15-20 minutes. Drug is quickly removed by kidneys - 40%-60% of the entered quantity in 4 hours are allocated with urine in not changed look. At disturbance of secretory function of kidneys concentration of aminocapronic acid considerably increases in blood

Indications to use:

Bleedings (a hyper fibrinolysis, hypo - and an afibrinogenemiya). Bleedings at surgical interventions on the bodies rich with fibrinolysis activators (a head and spinal cord, lungs, heart, vessels, thyroid and pancreatic glands, a prostate). Diseases of internals with a hemorrhagic syndrome. Premature placental detachment a long delay in cavities of the uterus of a dead fruit, the complicated abortion. For the prevention of a secondary hypofibrinogenemia at massive transfusions of stored blood

Route of administration and doses:

Aminocapronic acid is entered intravenously. The daily dose for adults makes 5-30 g. In need of achievement of bystry effect (an acute hypofibrinogenemia) enter intravenously kapelno up to 100 ml of sterile 5% of solution on isotonic solution of sodium of chloride with a speed of 50-60 thaws a minute. 

 Within  1 hour enter in a dose 4-5 g,  in case of the proceeding bleeding - to its full stop — on 1 g each hour no more than 8 hours.  

 If necessary    aminocaproic to repeat introduction of 5% of acid solution.

To children — at the rate of 100 mg/kg of body weight in the first hour, then 33 mg/kg/h, the maximum daily dose — 18 g/m2 of a body surface. Therapy duration - 3-14 days

Features of use:

Use at pregnancy and during breastfeeding – use of drug is admissible if the expected advantage for mother prevshat potential risk for a fruit and the child.

Purpose of drug demands check of fibrinolitic activity of blood and concentration of fibrinogen in blood. At in introduction control of a koagulogramma is necessary, especially at coronary heart disease, a myocardial infarction, at pathological processes in a liver.

Side effects:

Dizziness, sonitus, headache, nausea, diarrhea, inflammation of upper respiratory tracts, nose congestion, skin rash, orthostatic arterial hypotension, spasms, acute renal failure, subendocardial hemorrhage, рабдомиолиз, decrease in the ABP.

Interaction with other medicines:

It is possible to combine with introduction of gidrolizator, solution of glucose, antishock solutions. At an acute fibrinolysis it is in addition necessary to enter fibrinogen in an average daily dose of 2-4 g (a max. dose - 8 g).

Decrease in efficiency at a concomitant use of anticoagulants of direct and indirect action, antiagregant.

Contraindications:

Hypersensitivity to drug, tendency to fibrinferments and tromboembolitichesky diseases, hypercoagulation (A thrombogenesis, a tromboemboniya), coagulopathies owing to a diffusion vnitrisosudisty blood coagulation, a disease of kidneys with disturbance of secretory function, a hamaturia, pregnancy, disturbances of cerebral circulation

Overdose:

Sharp decrease in fibrinolitic activity of blood. The expressed symptoms of side effect - dizziness, a headache, nausea, diarrhea, a nose congestion, skin rash, orthostatic arterial hypotension, spasms, an acute renal failure, рабдомиолиз, a myoglobinuria.

Treatment - in case of overdose administration of drug is stopped and carry out the corresponding symptomatic therapy.

Storage conditions:

List B. In the dry, protected from light place at a temperature not above 25 °C. In the place, unavailable to children. Period of validity 3 years. On expiry date not to apply

Issue conditions:

According to the recipe

Packaging:

Solution for infusions of 50 mg/ml. On 100 or 200 ml in bottles glass for blood, tranfuzionny and nfuzionny drugs with a capacity of 100 or 250 ml respectively. Each bottle together with the application instruction is placed in a pack from a cardboard. Packaging for hospitals: on 56 bottles with a capacity of 100 ml or 28 bottles with a capacity of 250 ml place in boxes from the cardboard corrugated together with the application instruction in the quantity corresponding to the number of bottles