Aminocapronic acid

General characteristics. Structure:

Active ingredient: 50 mg of aminocapronic acid in 1 ml of solution.

Excipients: sodium chloride, water for injections.

Kroveostanavlivayushchy drug.

Pharmacological properties:

Pharmacodynamics. Aminocapronic acid oppresses a blood fibrinolysis. Blocking plasminogen activators and partially oppressing effect of plasmin, aminocapronic acid has specific styptic effect at the bleedings connected with increase in a fibrinolysis. Besides, aminocapronic acid slows down the activating action of Streptokinasa, urokinase and fabric kinases on a fibrinolysis, neutralizes effects of kallikrein, trypsin and hyaluronidase, reduces permeability of capillaries.

Pharmacokinetics. At intravenous administration action is shown in 15 — 20 minutes. Drug is quickly removed by kidneys: about 40 — 60% of the entered quantity in 4 hours are allocated with urine in not changed look. At disturbance of secretory function of kidneys there is a delay of removal of aminocapronic acid owing to what its concentration sharply increases in blood.

Indications to use:

Aminocapronic acid is applied to a stop and prevention of the bleedings caused by the increased fibrinolitic activity of blood, and also states hypo - and afibrinogenemiya. Drug is appointed at operative measures on the bodies rich with fibrinolysis activators (lungs, a brain, a uterus, prostatic, thyroid and pancreatic glands, adrenal glands); after heart operations and vessels; at extracorporal blood circulation; burn disease; at premature placental detachment; the complicated abortion, uterine bleedings; at operations in an ear, a throat, a nose, at nasal bleedings; at diseases of internals with a hemorrhagic syndrome (gastrointestinal bleedings, bleedings from a bladder, etc.). Aminocapronic acid is applied also to the prevention of a secondary hypofibrinogenemia at massive transfusions of stored blood.

Route of administration and doses:

Acid solution of aminocaproic is entered intravenously.

The adult the drug is administered intravenously in the form of 5% of solution in quantity to 100 ml kapelno with a speed of 50 — 60 thaws a minute (within 15 — 30 min.). Within the first hour it is recommended to enter 4 — 5 g (80 — 100 ml) of drug, and then if necessary on 1 g (20 ml) each hour within about 8 hours or to a full stop of bleeding. In case of the proceeding or repeated bleeding of an injection of 5% of acid solution of aminocaproic repeat each 4 hours.

Administration of acid solution aminocaproic can be combined with injection of solution of glucose, hydrolyzates and antishock solutions. At an acute fibrinolysis when the content of fibrinogen in blood sharply falls, administration of aminocapronic acid needs to be supplemented with the subsequent infusion of fibrinogen.

Features of use:

During treatment aminocapronic acid does not recommend to eat greasy food.

Precautionary measures. At use of aminocapronic acid it is necessary to check fibrinolitic activity of blood and content of fibrinogen. Intravenous administration of drug is recommended to be made under control of a koagulogramma. Especially careful control should be carried out at patients with heart diseases (coronary heart disease, a state after a heart attack) and a liver.

Side effects:

The increased individual sensitivity to drug which is expressed in dizziness, nausea, diarrhea, Qatar of upper respiratory tracts, skin rashes, orthostatic hypotonia, spasms is in certain cases observed. In this case it is necessary to reduce a dose or to cancel drug.

Interaction with other medicines:

The effect of drug is reduced by anticoagulants (direct, indirect), antiagregant.

Contraindications:

Use of aminocapronic acid is contraindicated at tendency to thrombosis and thromboembolic diseases, at coagulopathies because of diffusion intravascular coagulation, at diseases of kidneys with disturbance of their function, at pregnancy, disturbances of cerebral circulation, the IDCS, bleedings from upper respiratory tracts of an unspecified etiology.

Storage conditions:

In dry, protected from light, the place, unavailable to children, at a temperature from 2 to 25 °C. Period of validity. 3 years. Not to use after the period of validity specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Solution for infusions of 5% in bottles or polyethylene tanks on 100 or 200 ml.