Ambenum

General characteristics. Structure:

Active agent: the aminomethylbenzoic acid (Ambenum) - 10 mg.

Excipients: sodium chloride, water for injections.

Pharmacological properties:

Pharmacodynamics. AMBENUM belongs to fibrinolysis inhibitors, synthetic analogs of a liyozin. On the action the epsilon aminocapronic acid is similar, however is znayochitelno more effective than it. Specific styptic action of AMBENUM at the bleedings caused by increase in a fibrinolysis is connected with blockade of akyotivator of plasminogen and partial oppression of influence of plasmin. AMBENUM inhibits a fibrinolysis, competitively sating a lysine - the connecting receptors thanks to which plasminogen (plasmin) contacts fibrinogen (fibrin). Drug inhibits also biogenic polypeptides-kininy.
AMBENUM strengthens detoksitsiruyushchy function of a liver, the antibody response oppresses.

Pharmacokinetics. At internal introduction the maximum concentration of drug in blood is defined right after introduction and remains till 3 o'clock. AMBENUM is brought out of an oryoganizm by kidneys: 60% of-80% in an invariable look. At disturbance of a secretory funkyotion of kidneys concentration of AMBENUM considerably increases in blood.

Indications to use:

- states at which the system hyper fibrinolysis develops (a peredoziyorovka of plasminogen activators: Streptokinasas, urokinases, etc.);
-  at decline in the ability to formation of haemo static blood clot (at disturbance of procoagulant, platelet or vascular components of a hemostasis);
-  at the localized hemorrhages owing to strengthening of local fibrinolitic activity (after a tonsilectomy, prostate, bladder operations, menorrhagias);
- at surgeries and different pathological proyotsessa with increase in fibrinolitic activity of blood; brain operations (including, at subarachnoidal hemorrhages), lung, heart operations, vessels, thyroid and pancreatic glands; after dental interventions, at premature amotio of normally located placenta, a long delay in a cavity of the uterus of a dead fruit, uterine bleeding; at acute pancreatitis; liver diseases; nasal, zheludochyono-intestinal bleedings.
- the prevention of development of a secondary hypofibrinogenemia at massive transfusions of stored blood.

Route of administration and doses:

The drug is administered intravenously struyno or kapelno, previously having dissolved necessary amount of drug in 250 ml of 0,9% of solution of sodium of chloride or 5% of solution of glucose. The dose of drug makes 0,5-1,5 mg/kg 3-4 times a day or 2,5-5 mg/kg a day, at the prolonged infusion, with a speed of 100 mg/h.

For interruption of fibrinolitic activity (Streptokinasa, an urokinase) AMBENUM is entered intravenously in a dose of 50 mg. If necessary it is possible to repeat introduction not less than in 4 hours. At an acute fibrinolysis in addition enter fibrinogen, кон­тролируя fibrinolitic activity of blood and content of fibrinogen in it.

Features of use:

Purpose of drug demands check of fibrinolitic activity of blood and level of fibrinogen. At intravenous administration control of a koagulogramma is necessary, especially at coronary heart disease, after a myocardial infarction, at liver zaboleyovaniye.

Introduction of AMBENUM can be combined with introduction of hydrolyzates, especially a rasyotvor of glucose, antishock solutions. At an acute fibrinolysis in addition enter fibrinogen (an average dose of the last - 2 - 4 g, maximum - 8 g).

Side effects:

From the alimentary system: nausea, vomiting, diarrhea.
From CCC: increase or decrease in the ABP, tachycardia.
Local reactions: thrombophlebitis in the place of an injection.
Others: renal colic, the catarral phenomena from upper respiratory tracts, dizziness.
Dizziness, orthostatic hypotension, spasms are in certain cases observed. At the same time it is necessary to reduce a dose or to cancel drug.

Interaction with other medicines:

Simultaneous use of high doses of AMBENUM and other hemostatics (e.g. etamsylate) can lead to formation of tromyob, on the one hand, due to strengthening of formation of fibrin under the influence of gemostatik, and on the other hand, due to slow dissolution of the formed blood clots in view of anti-plasmin action of AMBENUM.

Contraindications:

Tendency to fibrinferments and thromboembolic diseases, hypersensitivity, hypercoagulative phase of the IDCS, vitreous hemorrhage, severe forms of coronary heart disease and ischemia of a brain, at diseases of kidneys with disturbance of their function, a beremenyonost and the period of a lactation.

With care to apply at disturbances of cerebral circulation!

Use at pregnancy and during breastfeeding
Drug is contraindicated in the I trimester of pregnancy and during breastfeeding.

Overdose:

The overdose by drug meets extremely seldom and is characterized by the increased coagulability of blood. In case of overdose intravenous administration of heparin in a dose 5000 ME and/or drug withdrawal is necessary.

Storage conditions:

In the place protected from light, at a temperature not above 25 °C, unavailable to children.

Issue conditions:

According to the recipe

Packaging:

Solution for intravenous administration of 10 mg/ml in ampoules on 5 ml. On 5 ampoules in a strip packaging from a film polyvinyl chloride. On 2 strip packagings together with the application instruction in a pack from a cardboard bandbox.