Laktasol

General characteristics. Structure:

Active ingredients: 6,2 g of sodium of chloride, 0,3 g of potassium of chloride, 3,36 g of sodium of a lactate, 0,316 g of Calcii chloridum, 0,213 g of magnesium of chloride.

Excipients: water for injections – to 1 l.

The drug rendering the recovering water and electrolytic balance, the disintoxication, normalizing KShchS, plasma substituting action.

Pharmacological properties:

Indications to use:

Apply at the acute circulator disorders which are followed by dehydration at burns, hemorrhagic, operational and postoperative shock, peritonitis, diarrhea of various etiology, and also at a metabolic acidosis.

Route of administration and doses:

Enter intravenously struyno or kapelno.

Traumatic shock. One Laktasol's use (he has no the expressed hemodynamic effect) is shown only in shock cases, and, in the beginning the drug should be administered struyno, and at improvement of hemodynamic indicators pass to a drop method of introduction.

At heavy shock лактасол it is recommended to apply in combination with blood, Polyglucinum, plasma, only the poteiny ambassador of removal of the patient from a condition of heavy hemodynamic crisis. The dose of a laktasol in this case is established individually depending on a condition of the patient.

Burn disease. Laktasol's use is shown in the entire periods of a burn disease. In Iperiode one Laktasol's use is admissible at burns of 10-15% of a body surface. At more extensive thermal injuries, especially at deficit of volume of plasma and low arterial pressure, drug should be combined with Polyglucinum, plasma, albumine. The dose of a laktasol at the combined treatment has to make not less than 1-2 l in the first days. In second day ½ volumes, entered in the first 24 hours. In the second and third periods of a burn disease Laktasol apply at the expressed intoxication and disturbance of water and electrolytic and acid-base balance. The dosage of a laktasol in these cases depends on weight of manifestation of the specified disturbances and fluctuates from 400 to 1000 ml.

At acute circulator disorders as a result of heavy it is purulent - surgical complications (peritonitis, pancreatitis, sepsis) use drug within 3-4 days in a combination with Haemodesum, blood, plasma, a protein, reopoliglyukiny. Also apply solution Laktasol at deficit of water and electrolytes and disturbance of acid-base equilibrium at intestinal impassability, intestines paresis, ulcer colitis, a coloenteritis, dysentery, diarrhea.

Prevention of hypotensive complications at operations, substitution of operational blood loss and deficit of extracellular liquid. In the preoperative, operational, postoperative period enter from 0,5 to 3 l of solution depending on degree of a local injury and blood loss, at the expressed blood loss appoint drug in combination with blood and colloids.

Acute blood loss. Use of a laktasol without other transfusion means is justified at blood loss no more than 500 ml in the volume exceeding blood loss size by 3-4 times. At the large volume of blood loss drug should be used in combination with blood, eritrotsitny weight, Polyglucinum as means of normalization of water and electrolytic and acid-base balance.
Compensation of a metabolic acidosis. The drug dose in this case depends on extent of atsidotichesky shift. At moderately expressed acidosis (decrease in VE on 1,5 ¼Ý¬ó/l and more) there is enough introduction of 500 ml of solution. At deep acidosis with deficit of the bases more than 5 ¼Ý¬ó/l normalization of buffer capacity of blood can be reached by introduction of high doses of drug (1500 ml and more). On average infusion of 500 ml of solution leads to increase in buffer capacity of blood on 1-1,5 ¼Ý¬ó/l. For calculation of a necessary dose of drug it is possible to use the rule: in the conditions of the recovered hemodynamics (arterial pressure more than 80 ml hg) to enter 0,2-0,3 мэкв. the bases (on kg of weight of the patient) on 1 piece of negative change of VE, in view of that contains in 1 l of solution 36 мэкв. bases.

In view of soft buffer action лактасол it is possible to apply for lack of diagnostic methods of disturbances of acid-base equilibrium in cases when development or existence of a metabolic acidosis is supposed.

Use of a laktasol for the purpose of compensation of acidosis at extremely heavy patients is not effective.

Correction of water and electrolytic balance.

Side effects:

At transfusion of a laktasol the fever and temperature increase in some cases can be observed. For prevention of these phenomena at jet transfusion to use the solution which is warmed up to +30-+35 °C.

Interaction with other medicines:

Increase in a delay of sodium in an organism at a concomitant use of the following medicines is possible: non-steroidal anti-inflammatory drugs, androgens, anabolic hormones, estrogen, corticotropin, mineralokortikoid, vazodilatator, ganglioblokator.

At reception with kaliysberegayushchy diuretics, APF inhibitors and drugs of potassium the risk of development of a hyperpotassemia amplifies.

In a combination with cardiac glycosides the probability of their toxic effects increases.

Alkalinizes urine and slows down removal of the drugs having alkali reaction. Accelerates release of salicylates.

Contraindications:

It is contraindicated at an alkalosis, especially dekompensirovanny, and (like other similar solutions) in the presence of contraindications to introduction to an organism of a large amount of liquid.

It is recommended to limit the volume of infusion of drug in case of the developed renal failure, at burns of respiratory tracts, and also at patients of advanced and senile age.

Overdose:

In case of overdose there can be a disturbance of balance of water and electrolytes (a hypervolemia, a hypernatremia, a hyperpotassemia, a hypercalcemia, a hyperchloremia) and acid-base equilibrium. If necessary carry out a hemodialysis and peritoneal dialysis. In most cases it is enough to interrupt administration of solution.

Storage conditions:

In the place protected from light at a temperature not above +25 °C. Period of validity 2 years.

Issue conditions:

According to the recipe

Packaging:

On 250, 500, 1000 or 2000 ml in polymeric containers for infusion solutions.