Gepadif

General characteristics. Structure:

Main physical and chemical properties: heterogeneous porous weight from white with a pink shade till pink-brown color; 
Active agents: 1 bottle contains a carnitine of an orotat 300 mg (that is equivalent to 147,6 mg of acid of orotovy and 152,4 mg of a carnitine), a DL carnitine of a hydrochloride of 184 mg (that is equivalent to 150 mg of a carnitine), anti-toxic fraction of extract of a liver of 25 mg (that contains not less than 0,00025 mg of cyanocobalamin), adenosine of 5 mg, a pyridoxine of a hydrochloride of 25 mg, cyanocobalamin of 0,25 mg; 
excipients: D-manitol, methylparahydroxybenzoate, пропилпарагидроксибензоат.

Pharmacological properties:

Gepadif - the combined drug which effects are caused by complex action of the components which are its part. Stimulates metabolism of fats - components β-okislitelno of transformation of free fatty acids in mitochondrions of hepatocytes, biosintetichn processes, prevents a necrosis of hepatocytes, normalizes process of proliferation of hepatocytes, system of liver enzymes and recovers normal function of a liver. Existence of adenosine, being a component of coenzyme, nucleic acids, provides regulation of processes of a kroveobrazovaniye. Group B vitamins (cyanocobalamin, Riboflavinum, a pyridoxine) regulate oxidation-reduction processes, participate in proteinaceous, fatty and carbohydrate metabolism, in tryptophane exchange, methionine, to cysteine, glyutaminovo of acid and other amino acids. The pyridoxine contributes to normalization of lipidic exchange. Cyanocobalamin participates in process трансметилювання, hydrogen transfer, education methionine, nucleic acids, sincaline, to creatine. 
The carnitine promotes splitting of fatty long chain acids and substitution of fatly acid metabolic shunt carbohydrates, improves digestion of food. 
The anti-toxic fraction of extract of a liver is the cleared anti-toxic extract from a liver and attracts anti-toxic effect. 
Gepadif improves digestion, the zhelchevydeleniya improves, facilitates absorption of carbohydrates in a small intestine, is necessary for maintenance of normal intestinal microflora. Promotes improvement of glikogenofiksiruyushchy, synthetic, anti-toxic function of a liver, increases sensitivity of cells to effect of insulin, promotes release of insulin. 

Pharmacokinetics. After intravenous drop administration distribution of active components of drug - water-soluble vitamins of group B (cyanocobalamine, a pyridoxine), a carnitine, anti-toxic fraction of extract of a bull liver, adenosine happens preferential in a liver and kidneys. The pyridoxine is metabolized in a liver with formation pharmacological of active metabolites (pyridoxal phosphate, piridoksamino-phosphate), distributed in muscles, a liver, the central nervous system. A conclusion is carried out preferential by kidneys.

Indications to use:

- Acute and chronic hepatitis, cirrhosis (as a part of complex therapy); 
- Fatty dystrophy of a liver (liver steatosis); 
- Alcoholic damage of a liver; 
- Intoxication owing to long reception of antineoplastic, antitubercular and other drugs.

Route of administration and doses:

Gepadif apply intravenously kapelno once a day. The average daily dose for adults makes 8625 mg/kg of body weight - contents of 1 bottle of the drug dissolved in 400-500 ml of 5% of solution of glucose (dextrose). The maximum daily dose makes 17,25 mg/kg of body weight - contents of 2 bottles of the drug dissolved in 400-500 ml of 5% of solution of glucose (dextrose). 
To children of 7-14 years the daily dose of drug does not differ from an average daily dose for adults. The dosage can be adjusted by the doctor. 
Duration of treatment depends on a current of a basic disease and is defined by the doctor individually.

Features of use:

Pregnancy and lactation. A negative impact of drug during pregnancy and feeding by a breast it is not registered, however at Gepadif's appointment to pregnant women or women who nurse, it is necessary to consider carefully a ratio of advantage of use of drug with potential risk. 

Influence on ability to manage vehicles and other mechanisms. The negative impact on ability to manage vehicles and other mechanisms is not registered. 
Due to the lack of clinical experience of use Gepadif can be applied at children under 7 years only in that case when the expected therapeutic effect of use of drug surpasses potential risk for the child.

Side effects:

Usually drug is transferred well. 
At use of drug allergic reactions can sometimes be observed (skin rash, a small tortoiseshell, an abdominal pain, nausea, vomiting, diarrhea.

Interaction with other medicines:

Clinically significant medicinal interaction of Gepadif with other drugs is not described.

Contraindications:

Individual intolerance of components of drug. 
Children up to 7 years.

Overdose:

At overdose nausea, vomiting diarrhea are observed. 
Treatment. At overdose the symptomatic treatment is shown.

Storage conditions:

To store in the place, unavailable to children, in original packaging, at a temperature not above 25 °C.

Period of validity - 3 years. 
Drug should not be used after the expiry date specified on packaging.

Issue conditions:

According to the recipe