Motillion

General characteristics. Structure:

Deystvuyushcheeveshchestvo: 10 mg of a domperidon.

Excipients: lactose, starch corn, povidone, dye Supr's Tartrazine (Е 102), talc, magnesium stearate, colloid silicon dioxide.

Antiemetic drug, stimulator of motility of a GIT.

Pharmacological properties:

Pharmacodynamics. Domperidon is the antagonist of a dopamine possessing similar to Metoclopramidum and some neuroleptics, antiemetic properties. However unlike these drugs домперидон badly gets through GEB. Use of a domperidon seldom is followed by extrapyramidal side effects, especially at adults, but домперидон stimulates release of prolactin from a hypophysis. Antiemetic action, perhaps, is caused by a combination of peripheral (gastrokinetichesky) action and antagonism to dopamine receptors in a trigger zone of chemoceptors.

At intake домперидон increases duration of antral and duodenal reductions, accelerates gastric emptying - an exit of liquid and semisolid fractions at healthy people and firm fractions at patients in case this process was slowed down, and increases pressure of a sphincter of a lower part of a gullet at healthy people. Domperidon has no effect on gastric secretion. It is quickly and rather fully soaked up in a GIT. The maximum concentration is reached within 60 min. Contacts proteins of plasma for 91-93%. Badly gets through GEB. The elimination half-life makes 7-9 h. It is allocated with urine (31%) and excrements (66%).

Indications to use:

– the complex of dispepsichesky symptoms which is often associated with the slowed-down gastric emptying, a gastroesophagal reflex, an esophagitis (feeling of overflow in epigastriums, feeling of abdominal distention, pain in an upper part of a stomach, an eructation, a meteorism, nausea, vomiting, heartburn and regurgitation);

– the nausea and vomiting of a functional, organic, infectious origin caused by radiotheraphy, medicinal therapy or disturbance of a diet;

– the nausea and vomiting caused by dopamine agonists in case of their use at Parkinson's disease (such as L-dopa and Bromocriptinum);

– a vomiting syndrome, cyclic vomiting, a gastroesophagal reflex and other disturbances a motorikizheludka at children.

Route of administration and doses:

Inside, in 30 min. prior to food. To adults and children 5 years at the chronic dispepsichesky phenomena are more senior - on 10 mg 3-4 times a day and in case of need in addition before going to bed.

At the expressed nausea and vomiting - on 20 mg 3-4 times a day and before going to bed. To children up to 5 years at the chronic dispepsichesky phenomena - on 2.5 mg / 10 kg 3 times a day and in case of need in addition before going to bed. At the expressed nausea and vomiting - on 5 mg / 10 kg 3-4 times a day and before going to bed.

If necessary the dose can be doubled. Dose adjustment is necessary for patients with a renal failure, frequency rate of reception should not exceed 1-2 times during the day.

Features of use:

At simultaneous use of Domperidon with antiacid or anti-secretory drugs the last need to be accepted after meal, i.e. they should not be accepted along with Domperidon. With care it is necessary to appoint Domperidon sick with a liver failure, considering high extent of metabolism of a domperidon in a liver. At long therapy patients have to be under regular observation.

Use in pediatrics. Because processes of metabolism and the GEB function in the first months of life are developed not completely, children of chest age should appoint any drug very carefully and under careful medical observation. Since lack of influence, typical for Domperidon, on TsNS generally is result of poorly expressed penetration through GEB, emergence of neurologic symptoms cannot be excluded completely at children aged till 1 year.

The overdose can cause neurologic side effects in children. Influence on ability to driving of motor transport and to control of mechanisms Domperidon does not exert impact on ability to driving and work with mechanisms.

Side effects:

From a digestive sistemy:redko – disorder of a GIT; in isolated cases - passing enterospasms.

From TsNS: extrapyramidal symptoms (it is very rare - at children; in isolated cases - at adults); are completely reversible and disappear after the treatment termination. At GEB underdevelopment (for example, at children till 1 year) or disturbance of its functions it is impossible to exclude completely a possibility of emergence of neurologic side effects.

From endocrine system: the giperprolaktinemiya which is seldom leading to a galactorrhoea, a gynecomastia, an amenorrhea is possible.

Allergic reactions: seldom - rash, urticaria.

Interaction with other medicines:

Cimetidinum, Natrii hydrocarbonas reduce bioavailability of a domperidon.

Anticholinergic HP neutralize action of a domperidon. Increase concentration of a domperidon in plasma: antifungal HP of an azolovy row, antibiotics from group of macroleads, HIV protease inhibitors, нефазодон (antidepressant).

Let's combine with reception of antipsychotic HP (neuroleptics), agonists of dofaminergichesky receptors (Bromocriptinum, L-dopa).

The concomitant use with paracetamol and digoxin did not exert impact on concentration of these HP in blood.

Contraindications:

– gastrointestinal bleeding;

– mechanical impassability or perforation at which stimulation of motive function of a stomach can be dangerous;

– prolactin - the cosecreting tumor of a hypophysis (prolaktinom).

– concomitant use of peroral forms of a ketokonazol;

– hypersensitivity to drug components.

Storage conditions:

To store in the place protected from moisture and light at a temperature not over +25 ºС. To store in the place, unavailable to children. Period of validity 3,5 years

Issue conditions:

Without recipe

Packaging:

On 10, 20 or 30 tablets in bank of polymeric. 10 tablets in a blister strip packaging. Bank either 1, or 2, or 3 blister strip packagings with a leaf insert in a cardboard pack.