Ceruloplasmin

General characteristics. Structure:

Active ingredient: 100 mg of ceruloplasmin (medsoderzhashchy enzyme _{of alfa2-globulinovy} fraction of the blood serum received from donor plasma of the person) in 1 ampoule.

Pharmacological properties:

Pharmacodynamics. Disintoxication means. Performs a number of important functions in an organism: is the main carrier of copper in an organism; participates in iron metabolism; is antioxidant, connects superoxidic radicals and interferes with peroxide oxidation of lipids of cellular membranes, increases stability of cellular membranes; accelerates completion of quantity of erythrocytes at treatment of anemias of various etiology, exerts protective impact both on erythroidal, and on myeloid and lymphoid hemopoietic elements; participates in immune responses; participates in ion exchange; reduces intoxication and an immunosuppression at treatment of the diseases connected using means himio-and radiotheraphy.

Indications to use:

— anemias of various genesis at adults and children (6 months are more senior);

— leukopenia;

— cachexia;

— intoxication;

— in complex therapy of oncological patients;

— preoperative preparation at the weakened patients with anemia;

— massive and moderate blood loss during surgical intervention;

— it is purulent - septic complications in the early postoperative period;

— osteomyelitis (acute and chronic).

Route of administration and doses:

In/in kapelno with a speed adult 30 thaws/min., at children have 40-50 thaws/min. Contents of one ampoule dissolve 0.9% of solution of sodium of chloride in 200 ml. It is not recommended to exceed the specified rate of administering. Drug is used in the conditions of a hospital.

The following dosages are recommended.

The oncological patient during preoperative preparation Ceruloplasmin enter 1.5-2.0 mg/kg of mass of bodies/days in a dose; a course of treatment 7-10 in/in introductions, daily or every other day, depending on a condition of the patient.

In the postoperative period the single dose is defined by the size of blood loss and makes from 1.5 mg/kg at a moderate loss of blood, to 6 mg/kg in case of massive blood loss. The course of treatment consists from daily (1 times/days) in/in introductions within 7-10 days.

When carrying out radio - and chemotherapy the single dose makes 4-6 mg/kg of body weight, the course of treatment consists from 10-14 in/in introductions (on 3 introductions to week).

For patients with hemoblastoses the single dose makes 1.5-3.0 mg/kg, a course of treatment 7-10 in/in the injections appointed daily by 1 times/days.

At acute osteomyelitis the single dose makes 2.5 mg/kg of body weight, the course of treatment consists from 5 in/in the introductions appointed daily or every other day. At chronic osteomyelitis Ceruloplasmin is entered on 5 mg/kg by 2-3 times with an interval of 1-2 days, and then do 3-7 introductions on 2.5 mg/kg.

In pediatric practice the following dosages are recommended:

— to children from 6 months to 1 year - 50 mg (100 ml of solution);

— from 1 year to 12 years - 100 mg;

— from 13 to 18 years - 200 mg.

For prevention and/or treatments of posthemorrhagic anemia at surgeries at children enter Ceruloplasmin within 2 days before operation, intraoperatsionno and within 2-10 days after operation.

For prevention and/or treatment of anemia at children with it is purulent - surgical diseases Ceruloplasmin is entered within 7-10 days daily in days of performing antibacterial therapy.

At children with oncological diseases for prevention and/or treatments of radiation anemia against the background of radiation therapy enter Ceruloplasmin throughout all course of radiotheraphy once a week; for prevention and/or treatments of toxic anemia enter Ceruloplasmin in days of chemotherapy throughout all course; for prevention and treatment of toxic and radiation anemia against the background of himioluchevy therapy Ceruloplasmin is entered in day of carrying out chemotherapy throughout all course of treatment once a week.

Features of use:

Use at pregnancy and feeding by a breast. It is used in complex therapy of anemia in II and III trimesters of pregnancy. Against the background of purpose of iron preparations (taking into account indicators of serumal iron and ferritin), in addition appoint Ceruloplasmin of 100 mg daily in/in kapelno within 5 days.

Administration of drug in the I trimester of pregnancy and in the period of a lactation is not recommended (due to the lack of data of efficiency and safety of use for this category of patients).

Use for children. It is contraindicated to children from 0 to 6 months (due to the lack of data of efficiency and safety of use for this category of patients).

In pediatric practice the following dosages are recommended:

— to children from 6 months to 1 year - 50 mg (100 ml of solution);

— from 1 year to 12 years - 100 mg;

— from 13 to 18 years - 200 mg.

For prevention and/or treatments of posthemorrhagic anemia at surgeries at children enter Ceruloplasmin within 2 days before operation, intraoperatsionno and within 2-10 days after operation.

For prevention and/or treatment of anemia at children with it is purulent - surgical diseases Ceruloplasmin is entered within 7-10 days daily in days of performing antibacterial therapy.

At children with oncological diseases for prevention and/or treatments of radiation anemia against the background of radiation therapy enter Ceruloplasmin throughout all course of radiotheraphy once a week; dlyaprofilaktik and/or treatments of toxic anemia enter Ceruloplasmin in days of chemotherapy throughout all course; for prevention and treatment of toxic and radiation anemia against the background of himioluchevy therapy Ceruloplasmin is entered in day of carrying out chemotherapy throughout all course of treatment once a week.

Special instructions. In exclusively exceptional cases at persons with the changed reactivity on blood preparations development of an acute anaphylaxis in this connection all persons who received drug have to be under medical observation is possible. Indoors, where administer the drug, there have to be means of antishock therapy. Administration of drug should be registered in the established registration forms with the indication of the name of drug, number of a series, date of production, a period of validity, manufacturer, Date of Introduction and side reactions on administration of drug.

Side effects:

In an initiation of treatment feelings of rush of blood to the person, nausea, a fever, short-term temperature increase, skin rashes (urticaria) are possible. In these cases it is necessary to lower a drug dose, to reduce rate of administering or to cancel drug.

Interaction with other medicines:

At administration of drug use separate system for in/in introductions. Use in complex therapy with other medicines.

Contraindications:

— children's age from 0 to 6 months (due to the lack of data of efficiency and safety of use for this category of patients);

— hypersensitivity to drugs of a proteinaceous origin.

Storage conditions:

To store drug at a temperature from 2 °C to 8 °C in the place, unavailable to children. A period of validity - 2 years. Not to use after a period of validity.

Issue conditions:

According to the recipe

Packaging:

100 mg - ampoules (5) - packs cardboard.
100 mg - ampoules (10) - packs cardboard.