Трибукс

General characteristics. Structure:

Active ingredient: 5 ml of suspension for internal use contain 24 mg of a trimebutin.

Excipients: sucrose, polysorbate 80, orange fragrance, orange yellow (Е 110).

Pharmacological properties:

Трибукс® contains тримебутин. Trimebutin influences smooth muscles of digestive tract, regulating work (motility), digestive tract. Does not influence the central nervous system.

Indications to use:

- The disorders of motility of digestive tract defined as a syndrome of the angry gut.
- Functional disorders of digestive tract and biliary tract: diarrhea, locks, abdominal pains, spastic conditions of intestines.

Route of administration and doses:

Adults
The dose usually makes 15 ml of suspension - 3 times a day.
In exceptional cases it is possible to accept 30 ml of suspension 3 times a day.

Treatment time
The medicine Tribuks® should be taken as long as the attending physician recommends. At emergence of feeling that effect of the medicine of Tribuks® very strong or very weak, it is necessary to see a doctor.

Use of the drug Tribuks® for children
The dose is measured depending on the body weight of the patient.
The dose of 1 ml/kg of body weight a day divided into 2 or 3 single doses is usually applied.
It is recommended to pour doser contents in a small bottle with food, on a spoon or in a glass and at once to allow the child to drink. Babies can add contents of the doser to a small bottle with water or milk. To vigorously stir up a small bottle before each use.

Use for children (approximate dosing):
less than 6 months:                              2,5 ml of suspension 2 - 3 times a day

from 6 to 12 months:                          5 ml of suspension 2 times a day

from 1 to 5 years:                                     5 ml of suspension 3 times a day

5 years are more senior:                                    1 0 ml of suspension 3 times a day

 

Features of use:

Medicine contains 600 mg of sucrose in 1 ml of the prepared suspension for internal use. Patients with a diabetes mellitus have to consider it.

Use of the drug Tribuks® with food and drink.
Medicine should be taken before food.
The prepared suspension can be accepted itself or having mixed with other liquid (e.g. water or milk).

Pregnancy
Before use of each medicine it is necessary to consult with the doctor or the druggist.
There are no sufficient data concerning use of a trimebutin during pregnancy. Therefore, prescription of medicine of Tribuks® until the end of the third month of pregnancy is not recommended. Medicine can be appointed of the fourth month of pregnancy, only if emergency appears.

Feeding period breast
Before use of each medicine it is necessary to consult with the doctor or the druggist.
Трибукс® it can be appointed to the feeding women only in urgent cases.

Influence on ability to driving of motor transport and to control of moving mechanisms
Трибукс®, accepted according to the recommended dosage, does not influence ability to driving of vehicles, service of cars and does not reduce psychophysical activity.

Medicine contains 600 mg of sucrose in 1 ml of the prepared suspension for internal use. It needs to be taken in attention to patients with a diabetes mellitus.
If the intolerance of some Sugars was found in the patient earlier, he has to consult with the doctor before drug intake.
Medicine can cause allergic reactions in connection with the maintenance of orange yellow.

The special means of care concerning preparation of medicine for use
Before use it is necessary to check whether protection of a cover is broken. For the purpose of preparation of suspension it is necessary to stir up easily a bottle for a loosening of granules. Then it is necessary to prepare suspension for internal use, adding not carbonated mineral water to the line designated on a bottle and to vigorously stir up a bottle for hashing of medicine. To place the doser in a bottle and to measure the corresponding volume of suspension. It is possible to accept only suspension, or to mix it with other liquid. After use it is necessary to rinse carefully the doser serving for suspension measuring off.
It is recommended to stir up a bottle before each use.

Side effects:

Often (from 1 to 10 persons on 100 people):
• drowsiness, slackness; - feeling of fatigue; - dizzinesses; - feeling of heat or cold; - headaches; - apathy;
- xerostomia; - taste disturbance; - diarrhea; - a digestive disturbance; - pains in epigastric area; - numbness of lips, nausea; - vomiting; - locks; - feeling of thirst.

Not really often (from 1 to 10 persons on 1 Ltd company of people):
• rash,
Seldom (from 1 to 10 persons on 10 Ltd companies of people):
• disturbance of a heart rhythm; - an abnormal liver function, including increase in activity of the ALAT hepatic enzymes and ASPAT in blood.

Very seldom (less than at 1 on 10 Ltd companies of people, including isolated cases):
• concern; - decrease in hearing; - hepatitis; - skin changes (itch, urticaria, reddening, bubbles, papules, exudation, multiformny erythema); - ischuria; - menstrual disturbance; - painful increase in a breast at women; - increase in a breast at men (gynecomastia); - pain in a breast.

If some of collateral symptoms amplified or there were any side reactions which are not specified in a leaf insert, it is necessary to report about it to the doctor or the druggist.

Interaction with other medicines:

It is necessary to report to the doctor or the druggist about all the drugs accepted now and earlier, even those which are given without recipe.

It is necessary to pay special attention of the doctor if the patient accepts any of the listed drugs:
- зотепин (antipsychotic drug),
• d-tubocurarine (the relaxant applied at the general anesthesia),
• цизаприд (the medicine applied at gastric diseases),
• procaineamide (the medicine applied at disturbance of cardiac performance),
• antagonists of calcium (the drugs applied at a hypertension and heart troubles),
• captopril (the medicine applied at a hypertension),
• Reserpinum (the medicine applied at a hypertension),
• midazolam (the medicine applied at sleep disorders).

Contraindications:

The medicine Tribuks® is contraindicated at an allergy (hypersensitivity) on тримебутин or on any excipient of the medicine Tribuks®. If at the patient the fenilketonuriya is defined.

Overdose:

In case of reception bigger, than it is recommended doses of medicine it is necessary to consult at once with the doctor or the druggist, or to address to the nearest hospital.
In case of the admission of the next administration of drug of Tribuks
It is not necessary to apply a double dose of medicine for the purpose of completion of passed.
If the patient forgot to take medicine, has to accept the next dose of medicine in usual time.

Storage conditions:

Drug needs to be stored in the place, unavailable to children. To store in original packaging, at a temperature below 30 °C.
The period of validity in the specified conditions makes 3 years. Not to use drug after its period of validity.
To store the prepared suspension in the refrigerator (2 °C-8 of °C) no more, than 4 weeks. It is necessary to write down date of preparation of suspension.

Issue conditions:

According to the recipe

Packaging:

The bottle with a capacity of 100 ml from amber glass closed by a cover from polypropylene (RR). containing 61,0 g of granules (480 mg of a trimebutin) for preparation of suspension for internal use. To each packaging the doser (syringe) with a capacity of 1 5 ml is given.

The bottle with a capacity of 250 ml from amber glass closed by a cover from polypropylene (RR), containing 152,5 g of granules (1,2 g of a trimebutin) for preparation of suspension for internal use. To each packaging the doser (syringe) with a capacity of 15 ml is given.