Laksarin

General characteristics. Structure:

Active ingredient: 667 mg of lactulose in 1 ml of solution.

Excipients: no.

Osmotic purgative. Lactulose gets into intestines in not changed look where it is metabolized by a sakharolitichesky bacterial flora of a large intestine generally to lactic or acetic acid therefore pH and osmosis of a large intestine decreases, the peristaltics of intestines raises and, as a result, fecal masses is softened.

Pharmacological properties:

Pharmacodynamics. Lactulose is metabolized by a sakharolitichesky bacterial flora of a large intestine mainly to lactic or acetic acid. It is result of decrease рН and osmosis of a large intestine, the peristaltics of intestines raises owing to what excrements are softened.

Pharmacokinetics. At treatment of hepatic encephalopathy concentration of compounds of ammonium in blood decrease. High doses of lactulose reduce рН intestines, interfere with action of a proteolytic bacterial flora which reduces formation of ammonia and other harmful substances. At low value рН ammonia is ionized before compounds of ammonium which not so easily get through an intestines wall, diffusion of ammonia from blood to intestines is also activated. Increase in an intestinal vermicular movement causes the effects stated above.

The most part of lactulose gets into intestines in an invariable look where it is metabolized by a sakharolitichesky bacterial flora mainly to lactic or acetic acid. 2–3% of lactulose are absorbed and removed in an invariable view with urine.

Indications to use:

Locks: regulation of a physiological rhythm of intestines. The states demanding defecation ease (at patients with hemorrhoids, after intestines operations). Portosistemny hepatic encephalopathy: treatment and prevention of a hepatic coma and prekoma.

Route of administration and doses:

The dose of drug is selected individually. Effect of drug begins slowly, in 2–3 days that is caused by the mechanism of effect of lactulose. Drug can be used in pure form or mixing with liquid or food. It is better to accept a daily dose once a day, in the morning, during a breakfast.

Locks, states the demanding defecation eases. Adults. An initial dose - 15–45 ml a day, the supported dose - 15–30 ml a day. Children of 7-14 years. An initial dose - 15 ml a day. A maintenance dose – 10–15 ml a day. Children of 1-6 years. An initial dose - 5–10 ml a day. A maintenance dose – 5–10 ml a day. Children till 1 year. An initial dose - 5 ml a day. A maintenance dose – 5 ml a day.

The dose needs to be selected individually before achievement of soft excrements. If therapeutic reaction does not develop for 48 hours, the dose can be increased. If at the patient diarrhea develops, the dose of drug needs to be reduced.

Hepatic prekoma and coma. The initial dose makes 30–50 ml 3 times a day. The dose needs to be selected individually before achievement of 2-3 soft excrements in days. рН excrements there have to be 5,0–5,5.

More than 7 days are not recommended to use drug. In case of need extensions of a course control of the doctor is necessary.

Features of use:

Drug is used with care at patients with diabetes as at treatment of a hepatic coma drug is appointed as usual in the highest doses.

Drug contains lactose, a galactose, fructose, an epilaktoza and a tagatoza. Patients with the most rare hereditary intolerance of a galactose, a lactose intolerance of Lapp or malabsorption of glucose - galactoses should not use this medicine.

Use during pregnancy or feeding by a breast. In the recommended doses drug can be used during the periods of pregnancy and feeding by a breast.

Ability to influence speed of response at control of motor transport or work with other mechanisms. Drug does not influence speed of response at control of motor transport or work with other mechanisms.

Children. At locks drug is appointed to children, since chest age. There are no data about drug use to children at hepatic encephalopathy.

Side effects:

 Frequency of emergence of side effects: often (> 1/100), infrequently (> 1/1000 that <1/100), it is rare (<1/1000, including isolated cases).

Seldom: a hyponatremia (throughout treatment of hepatic encephalopathy).

Often: a meteorism and a peritoneal cavity pain, especially in an initiation of treatment; nausea, vomiting and diarrhea at use of high doses of drug. 

Interaction with other medicines:

The diarrhea caused by high doses of drugs can be result of insufficiency of electrolytes, such as potassium. In such cases use of drug can increase the shortage of potassium caused by other drugs and to exponentiate effects of cardiac glycosides.

Medicines which release depends from рН a large intestine (for example, 5-ACK) can be inactivated owing to reduction рН at lactulose use.

Contraindications:

Hypersensitivity to acting or to excipients, a galactosemia, impassability of digestive tract.

Overdose:

Information on cases of overdose of drug is absent. At use of very high doses of drug there can be an abdominal pain, diarrhea, loss of electrolytes. In need of cases of overdose carry out symptomatic therapy.

Storage conditions:

To store at the room temperature (15–25 °C) in the place, unavailable to children.

Issue conditions:

Without recipe

Packaging:

On 250 ml, 500 ml or 1000 ml in a plastic bottle.