Афобазол®

General characteristics. Structure:

Active agent: Afobazole (in terms of dry matter) — 5 mg or 10 mg.
Excipients: potato starch, cellulose microcrystallic, sugar milk (lactose), povidone, magnesium stearate.

Pharmacological properties:

Pharmacodynamics. Афобазол® — proizvodnoye2-mercaptobenzimidazole, the selection anxiolytic which is not belonging to the class of agonists of benzodiazepine receptors. Interferes with development of membranozavisimy changes a VGAMK-receptor.
Афобазол® possesses anxiolytic action with the activating component which is not followed by gipnosedativny effects (sedative action comes to light at Afobazola® in doses, at 40-50 times exceeding ED50 for anxiolytic action). Drug has no miorelaksantny properties, a negative impact on indicators of memory and attention. At its use medicinal dependence does not form and the withdrawal does not develop.

Effect of drug is implemented preferential in the form of a combination anxiolytic (antialarming) and easy stimulating (activating) effects.

Reduction or elimination of alarm (concern, bad presentiments, fears, irritability), tensions (fearfulness, tearfulness, feeling of concern, inability to relax, sleeplessness, fear) and consequently somatic (muscular, touch, cardiovascular, respiratory, gastrointestinal symptoms), vegetative (dryness in a mouth, perspiration, dizziness), cognitive (difficulties at concentration of attention, the weakened memory) disturbances it is observed for 5–7 day of treatment of Afobazolom®.

The maximum effect is reached by the end 4 weeks of treatment and remains within 1–2 weeks. Use of drug for persons with preferential asthenic personal lines in the form of alarming suspiciousness is especially shown, to uncertainty, the increased vulnerability and emotional lability, tendency to kemotsionalno-stressful reactions. Афобазолом® it is non-toxical (LD50 at rats makes 1,1 g at ED50 0,001 g).

Pharmacokinetics. The elimination half-life of Afobazola® at intake makes 0,82 hours, the average size of the maximum concentration (Cmax) — 0,130+0,073 mkg/ml, the average time of deduction of drug in an organism (MRT) — 1,6+0,86 hours of Afobazol® is intensively distributed on well vaskulyarizirovanny bodies.

Indications to use:

Афобазол® it is applied at adults at alarming states: generalized alarming frustration, a neurasthenia, disorders of adaptation, at patients with various somatopathies (bronchial asthma, a syndrome of the angry intestines, a system lupus erythematosus, coronary heart disease, an idiopathic hypertensia, arrhythmias), dermatological, oncological, etc. diseases. At treatment of the sleep disorders connected with alarm, neurocirculatory dystonia, a premenstrual syndrome, an alcoholic abstinence syndrome for simplification of a withdrawal at refusal of smoking.

Route of administration and doses:

It is applied inside, after food.
Optimum single doses — 10 mg; daily — 30 mg distributed on 3 receptions during the day. Duration of course use of drug makes — 2–4 weeks.
If necessary the daily dose of drug can be increased to 60 mg, and treatment duration up to 3 months.

Side effects:

It is applied inside, after food.
Optimum single doses — 10 mg; daily — 30 mg distributed on 3 receptions during the day. Duration of course use of drug makes — 2–4 weeks.
If necessary the daily dose of drug can be increased to 60 mg, and treatment duration up to 3 months.

Interaction with other medicines:

Афобазол® does not exert impact on narcotic effect of ethanol and hypnotic effect of thiopental. Exponentiates anticonvulsant effect of carbamazepine. Causes strengthening of anxiolytic effect of diazepam.

Contraindications:

Pregnancy, lactation period. Individual intolerance of drug. Children's age up to 18 years.

Overdose:

At considerable overdose and intoxication development of sedation and the increased drowsiness without muscle relaxation manifestations is possible. As acute management solution in ampoules is applied kofeinbenzoat-sodium of 20% on
1,0 ml 2–3 times a day subcutaneously.

Storage conditions:

In the dry, protected from light place, at a temperature not above +25 °C.

To store in the places unavailable to children.

Period of validity - 2 years. Not to use after the term specified on packaging.

Issue conditions:

Without recipe

Packaging:

Tablets on 5 mg or 10 mg.
On 10, 20 or 25 tablets in a blister strip packaging.
On 30, 50, 100 or 120 tablets in banks polymeric.
Each can or 3, 5 or 10 planimetric packagings on 10 tablets, or on 1, 2, 3, 4 or 6 planimetric packagings on 20 tablets, or 2 or 4 planimetric packagings on 25 tablets together with the application instruction are placed in a pack from a cardboard.