Cooks

General characteristics. Structure:

Active ingredient: not less than 2,5 IU (international units) of a vaccinal rhabdovirus, the strain of Vnukovo-32 inactivated - not less than 2,5 ME (the International Units).

Excipients: stabilizers: albumine solution for infusions of 10%, sucrose, gelatin. Drug does not contain preservatives and antibiotics.

The vaccine antirabic cultural concentrated cleared inactivated, lyophilisate for preparation of solution for intramuscular introduction, represents the drug containing the vaccinal rhabdovirus, the strain of Vnukovo-32 which is grown up in primary culture of cells of kidneys of the Syrian hamsters, inactivated by ultraviolet rays, concentrated and cleared by an ultrafiltration method.

Indications to use:

Treatment-and-prophylactic and preventive immunization of the person against rage.

Route of administration and doses:

Ampoule contents with a vaccine have to be dissolved in 1,0 ml of water for injections.

Time of dissolution should not exceed 5 min. The dissolved vaccine represents transparent or slightly opalescent liquid from colourless till light yellow color.

The dissolved vaccine is entered slowly intramusculary into a deltoid muscle of a shoulder, to children up to 5 years - into an upper part of a perednebokovy surface of a hip. Introduction of a vaccine to a rump is not allowed.

Rendering the antirabic help. The antirabic help consists of local processing of wounds, scratches, grazes, places of oslyuneniye and the subsequent introduction of antirabic vaccine KOKAB or, in the presence of indications, the combined administration of antirabic immunoglobulin (AIG) and antirabic vaccine KOKAB.

Interval between introduction of AIG and KOKAB - no more than 30 minutes.

Local processing of wounds. Local processing of wounds (stings, scratches, grazes) and places of oslyuneniye has to begin immediately or as soon as possible after a sting or damage. It consists in plentiful washing within several minutes (up to 15 minutes) a wound surface water with soap or other detergent (detergent) or, in case of lack of soap or detergent, the place of damage is washed out by a water stream.

After this edge of a wound it is necessary to process 70% alcohol or 5% spirit solution of iodine. Whenever possible it is necessary to avoid suture on wounds.

Suture is shown only in the following cases:

• at extensive wounds - several directing skin seams after pretreatment of a wound;
• according to cosmetic indications (imposing of skin seams on wounds of a face);
• underrunning of the bleeding vessels for a stop of outside bleeding.
In the presence of indications to use of antirabic immunoglobulin, it is used just before suture (see the section Dose of Antirabic Immunoglobulin (AIG)).

After local processing of wounds (damages) immediately begin treatment-and-prophylactic immunization.

Treatment-and-prophylactic immunization. Indications. Contact and stings of rabid people animals, animals with suspicion of a disease of rage, wild or unknown animals.

Contraindications. No. Pregnancy is not a contraindication.

All persons put risk of infection with rage are subject to treatment-and-prophylactic immunization. If there are indications to the combined treatment, then at first AIG and, is entered no more than in 30 min., after it KOKAB is entered.

Antirabic immunoglobulin (AIG) is appointed as soon as possible after contact with a mad animal or an animal with suspicion of a disease of rage, a wild or unknown animal.

Before administration of heterological (horse) antirabic immunoglobulin it is necessary to check individual sensitivity of the patient to horse protein (see. "The application instruction of immunoglobulin antirabic of blood serum of a horse, liquid").

Before administration of homologous (human) antirabic immunoglobulin individual sensitivity is not checked. Heterological antirabic immunoglobulin is entered no later than 3 days after a sting, homologous antirabic immunoglobulin is entered no later than 7 days after a sting.

Dose of antirabic immunoglobulin (AIG). Heterological (horse) antirabic immunoglobulin is appointed in a dose 40 ME to 1 kg of body weight.

The volume of the entered heterological antirabic immunoglobulin should not exceed 20 ml. Homologous (human) antirabic immunoglobulin is appointed in a dose 20 ME to 1 kg of body weight.

Administration of antirabic immunoglobulin (AIG). As it is possible the most part of the recommended dose of AIG it is necessary to infiltrirovat in fabric around a wound and in the depth of a wound.

Unused part of a dose of drug is entered deeply intramusculary into the place other than introduction of an antirabic vaccine.

Preventive immunization. Indications. With the preventive purpose immunize the persons having high risk of infection with rage (the staff of laboratories working with a street rhabdovirus; veterinary workers; huntsman, hunters, foresters; the persons performing works on catching and keeping of animals and other professional groups).

The vaccine is entered intramusculary into a deltoid muscle of a shoulder on 1,0 ml in the 0, 7 and 30 day. The revaccination is carried out once, in a dose of 1,0 ml in a year and further each three years.

Features of use:

Drug in ampoules with the broken integrity, marking is not suitable for use, and also at discoloration and transparency, at the expired period of validity, the wrong storage.

Opening of ampoules and the procedure of vaccination are carried out at strict implementation of rules of an asepsis. Storage of the dissolved vaccine is not allowed more than 5 min.

Vaccinated has to be under medical observation not less than 30 min. Places for carrying out inoculations have to be equipped with means of antishock therapy.

Use at pregnancy and during breastfeeding. Use of drug is possible only with the treatment-and-prophylactic purpose according to vital indications.

Side effects:

• Introduction of a vaccine can be followed by local or general reaction. Local reaction is characterized by an insignificant swelling, a hyperemia, redness, an itch, morbidity in the place of an injection, increase in regional lymph nodes. The general reaction can be shown in the form of an indisposition, a headache, weakness, fervescence.

Symptomatic therapy, use of the hyposensibilizing means is recommended. In rare instances neurologic symptoms can develop, such patient has to be urgently hospitalized.

• After administration of antirabic immunoglobulin from blood serum of a horse complications can be observed: the local allergic reaction coming for 1-2 day after introduction; a serum disease which comes most often for 6-8 day; acute anaphylaxis. In case of development of anaphylactoid reaction enter subcutaneously solution of adrenaline or noradrenaline in an age dosage and 0,2-1,0 ml of ephedrine of a hydrochloride of solution for injections of 5%.

At emergence of symptoms of a serum disease parenteral administration of antihistaminic medicines, corticosteroids, calcium drugs is recommended.

Interaction with other medicines:

During a course of treatment-and-prophylactic vaccination performing vaccination by other drugs is forbidden. After the end of vaccination against rage carrying out inoculations other vaccines is allowed not earlier than in 2 months.

Preventive vaccination is carried out not earlier than in 1 month after vaccination against other infectious disease.

Contraindications:

1. Acute infectious and noninfectious diseases, chronic diseases - inoculations carry out to stages of an aggravation or a decompensation not earlier than one month after recovery (remission).
2. System allergic reactions to the previous introduction of vaccine KOKAB (generalized rash, a Quincke's edema, etc.).
3. Allergic reactions to antibiotics.
4. Pregnancy.

Storage conditions:

In the dry, protected from light place, at a temperature of 2-8 °C. To store in the place, unavailable to children. A period of validity - 1,5 years.

Issue conditions:

According to the recipe

Packaging:

Lyophilisate for preparation of solution for intramuscular introduction is produced in a set: 1 ampoule of a vaccine – 1 dose (not less than 2,5 ME) and 1 ampoule of solvent (water for injections) – on 1 ml. On 5 sets together with the application instruction and the scarificator ampoule in a pack from a cardboard. When using ampoules with a ring of a break or a point for opening the scarificator ampoule does not invest.