Интетрикс

General characteristics. Structure:

Active agents: тилихинол 50 mg; tilikhinola N-dodecyl sulfate of 50 mg; тилброхинол 200 mg

Other ingredients: lactoses monohydrate, starch corn, gelatin, titanium dioxide (E171), azoruby (E122), indigotin (E132).

Pharmacological properties:

Pharmacodynamics. Интетрикс — antiparasitic, amebitsidny means. Drug affects Entamaeba histolytica trofozoita in their prosvetny form and cysts. The therapeutic effect at a chronic amebiasis is reached thanks to synergy action in a gleam of intestines of three antiseptic components which are a part of drug. Интетрикс it is effective concerning vegetative forms of amoebas, actions concerning Streptococcus faecalis, E. coli III.B4, Salmonella enteritidis Danysz, Salmonella paratyphy B, Pseudomonas aeruginosa, Proteus vulgaris, Vibrio cholerae Ogava, Vibrio cholerae Inaba, Serratia marcescens, etc., antifungal action concerning Candida albicans possesses also wide range antimicrobic (bactericidal and bacteriostatic). Интетрикс does not cause development of plasmid resistance of microorganisms and does not break a normal microbiocenosis of intestines.

Pharmacokinetics. At oral administration of Intetriks it is poorly soaked up by a mucous membrane that causes its effective concentration in an intestines gleam.

Indications to use:

Intestinal amebiasis at adults:

• as an additional tool to therapy by fabric amebicides;
• as monotherapy at an asymptomatic carriage of an amebiasis.
In complex treatment of a disbioz of intestines.

Route of administration and doses:

The adult appoint inside 2 capsules in the morning and 2 capsules in the evening. A daily dose — 4 capsules.
Capsules accept whole, before food, washing down with enough water. Duration of treatment should not exceed 10 days.

Features of use:

Results of clinical trials confirmed what at healthy volunteers of Intetriks often leads to moderate, asimptomny and reversible increase in level of hepatic transaminases. Therefore in case of increase in level of transaminases and especially at development of jaundice use of medicine should be stopped.
Long use of Intetriks is not recommended in view of risk of developing of peripheral neuropathy.
Интетрикс it is impossible to appoint along with other drugs containing hydroxyquinolines. Drug contains lactose therefore to patients with rare hereditary forms of intolerance of a galactose, insufficiency of lactase or a syndrome of glyukozo-galaktozny malabsorption it is not necessary to use drug.
At women of reproductive age drug is used only on condition of use of reliable methods of contraception.
Use during pregnancy and feeding by a breast. Experience of use of drug during pregnancy and feeding by a breast insufficient therefore it is not recommended to appoint drug of this category of patients.
Children. Do not apply at children.
Ability to influence speed of response at control of vehicles or work with other mechanisms. It is not established.

Side effects:

Increase in level of hepatic transaminases is in some cases noted. Development of cytolytic hepatitis is possible.
Occasionally there can be skin reactions (a small tortoiseshell, a Quincke's edema) or rashes of violent character (a constant pigmental erythema). Emergence of makulopapulezny rash is possible.
At long use peripheral neuropathy or damage of an optic nerve can develop.

Interaction with other medicines:

It is not necessary to appoint drug along with the medicines containing hydroxyquinolines. In order to avoid interaction between different medicines it is necessary to accept them separately with an interval not less than 2 h.

Contraindications:

The increased individual sensitivity to drug components.

Overdose:

So far about cases of overdose it was not reported.
At accidental use of drug in a high dose careful control of level of hepatic transaminases in a blood plasma, and also prothrombin level is necessary.

Storage conditions:

At a temperature not above 25 °C.

Issue conditions:

According to the recipe

Packaging:

In packagings of planimetric cell 10, 20 pieces; in a pack cardboard 1 or 2 packagings.