Furasolidone

General characteristics. Structure:

Active ingredient: 50 mg of a fuazolidon.

Excipients: potato starch, calcium stearate (calcium stearate) - 1 mg, sugar (sucrose), the twin-80 (polysorbate), lactose (sugar milk).

Pharmacological properties:

Pharmacodynamics. Antimicrobic means derivative of nitrofurans. It is active concerning gram-positive and gram-negative microbes, Trichomonas spp., Giardia lamblia. Are most sensitive to Shigella dysenteria spp furasolidone., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Salmonella typhi, Salmonella paratyphi.

Poorly influences on activators of a purulent and mephitic gangrene. Stability of microorganisms develops slowly. Blocks a monoaminooxidase. Nitrofurans break processes of cellular respiration of microorganisms, suppress a cycle of tricarboxylic acids (tricarbonic acid cycle), and also inhibit biosynthesis of nucleic acids of microorganisms therefore there is a destruction of their cover or cytoplasmic membrane.

As a result of effect of nitrofurans microorganisms emit less toxins in this connection improvement of the general condition of the patient is possible even before the expressed suppression of growth of microflora. Unlike many other antimicrobic medicines they not only do not oppress, and even activate immune system of an organism (raise a caption of a complement and ability of leukocytes to englobe microorganisms).

Pharmacokinetics. It is well absorbed at peroral introduction. Against the background of an inflammation of a meninx in liquor the concentration equal to that in plasma are created. It is quickly and intensively metabolized generally in a liver with formation pharmacological of an inactive metabolite (amin derivative). It is removed generally by kidneys (65%), small olichestvo are found in excrements where therapeutic concentration concerning causative agents of intestinal infections are reached.

Indications to use:

— dysentery;

— paratyphus;

— lambliasis;

— food toxicoinfections.

Route of administration and doses:

Inside, after food. At dysentery, paratyphus and food toxicoinfections - on 100-150 mg of 4 times/days (but no more than 800 mg), within 5-10 days.

At a lambliasis: the adult - on 100 mg of 4 times/days, children - 10 mg/kg/days, having distributed a daily dose on 3-4 receptions.

The highest single dose for adults - 200 mg; daily - 800 mg.

Features of use:

Use at abnormal liver functions. With care to patients with liver diseases.

Use at renal failures. Drug use is contraindicated to patients with an end-stage of a chronic renal failure.

With care to patients with a chronic renal failure.

Use for children. Drug use is forbidden to children under 3 years (for this dosage form).

Increases sensitivity to effect of ethanol.

During treatment precautionary measures have to be observed, as well as when using inhibitors of a monoaminooxidase, namely: an exception of a diet of the products containing tyramine: cheese, cream, haricot, marinated herring, strong coffee.

For prevention of neuritis at prolonged use it is necessary to combine with group B vitamins.

Side effects:

Loss of appetite, up to anorexia; nausea, vomiting; allergic reactions (skin rash, hyperemia and itch of skin. Quincke's disease).

At prolonged use - neuritis.

Interaction with other medicines:

Furasolidone in combination with ethanol can lead to development of disulfiramopodobny reactions in this connection their concomitant use is not recommended.

Antidepressants, monoaminooxidase inhibitors, ephedrine, amphetamine, Phenylephrinum, tyramine can cause sharp increase in the ABP.

The medicines alkalinizing urine reduce effect, and acidifying - raise.

Aminoglycosides and tetracycline increase antimicrobic properties.

Contraindications:

— pregnancy, lactation;

— the increased individual sensitivity to group of nitrofurans;

— end-stage of a chronic renal failure;

— deficit glyukozo-6-fosfatdegidrogenazy;

— children's age up to 3 years (for this dosage form).

With care. Chronic renal failure, deficit glyukozo-6-fosfatdegidrogenaza, diseases of a liver and nervous system.

Overdose:

Symptoms: acute toxic hepatitis, gematotoksichnost, neurotoxicity (polyneuritis).

Treatment: cancellation of HP, reception of a large amount of liquid, symptomatic therapy, antihistaminic HP, group B vitamins.

Storage conditions:

Drug should be stored in dry, protected from light and the place, unavailable to children. Period of validity 3 years. Not to apply after a period of validity.

Issue conditions:

According to the recipe

Packaging:

10 pieces - packagings bezjyacheykovy planimetric.
10 pieces - packagings planimetric cell (2) - packs cardboard.
10 pieces - packagings planimetric cell (3) - packs cardboard.
10 pieces - packagings planimetric cell (4) - packs cardboard.
10 pieces - packagings planimetric cell (5) - packs cardboard.
50 pieces - banks polymeric (1) - packs cardboard.