Emoksifarm of 1%

General characteristics. Structure:

Active ingredient: 10 g of an emoksin (metiletilpiridinol hydrochloride), 7,3 g of sodium of chloride.

Excipients: water for injections to 1 l.

The vasoprotective, reduces permeability of a vascular wall, is inhibitor of free radical processes, anti-hypoxanthomas and antioxidant.

Pharmacological properties:

Pharmacodynamics. The vasoprotective, reduces permeability of a vascular wall, is inhibitor of free radical processes, anti-hypoxanthomas and antioxidant. Reduces viscosity of blood and aggregation of thrombocytes, increases the maintenance of cyclic nucleotides (tsAMF and tsGMF) in thrombocytes and tissue of a brain, has fibrinolitic activity, reduces permeability of a vascular wall and a risk degree of development of hemorrhages, promotes their rassasyvaniye.

Expands coronary vessels, in the acute period of a myocardial infarction limits necrosis center size, improves sokratitelny ability of heart and function of its carrying-out system. At the raised ABP renders hypotensive effect. At acute ischemic disorders of cerebral circulation reduces weight of neurologic symptomatology, increases resistance of fabric to a hypoxia and ischemia.

Has retinoprotektorny properties, protects a retina from the damaging effect of light of high intensity, promotes a rassasyvaniye of intraocular hemorrhages, improves microcirculation of an eye.

Pharmacokinetics. At intravenous administration in a dose of 10 mg/kg the low period of semi-elimination is noted (T1/2 — 18 min. that testifies to the high speed of elimination of drug from blood). Elimination constant size — 0,041 min.; the general clearance of Cl — 214,8 ml/min.; the seeming volume of distribution of Vkazh. — 5,2 l. Drug quickly gets into bodies and fabrics where there is its deposition and metabolism. 5 metabolites of an emoksipin presented by the dialkylated and conjugated products of its transformation are revealed. Metabolites of an emoksipin are excreted by kidneys. In significant amounts in a liver 2-ethyl-6-methyl-3-oxypyridine-phosphate is found. At morbid conditions, for example, in case of coronary occlusion, the pharmacokinetics of an emoksipin changes.

Removal speed decreases owing to what bioavailability of drug increases. The time spent of an emoksipin in a circulatory bed increases that can be connected with its return receipt from depot, including from an ischemic myocardium.

Indications to use:

Disturbances of cerebral circulation of ischemic and hemorrhagic character, craniocereberal injuries, the postoperative period of Epi - and subdural hematomas; acute myocardial infarction, prevention of a syndrome of reperfusion, unstable stenocardia; subconjunctival and intraocular hemorrhage, an angioretinopatiya (including diabetic), chorioretinal dystrophy (including atherosclerotic genesis), a dystrophic keratitis, thrombosis of vessels of a retina, a myopia complication, operative measures in the eyes, a state after operation for glaucoma with choroid amotio.

Route of administration and doses:

In neurology and cardiology - in/in kapelno (20-40 caps/min.), on 20-30 ml of 3% of solution (600-900 mg) 1-3 times a day within 5-15 days (previously drug dissolve in 200 ml 0.9% of NaCl solution or 5% dextrose solution). Duration of treatment depends on the course of a disease. In the subsequent pass to introduction in oil - 3-5 ml of 3% of solution 2-3 times a day within 10-30 days.

Features of use:

Treatment should be carried out under control of the ABP and coagulability of blood.

Side effects:

Short-term excitement, drowsiness, increase in arterial pressure, allergic reactions (skin rashes, etc.), local reactions - pain, burning, an itch, a hyperemia, consolidation of paraorbital fabrics (resolves independently).

Interaction with other medicines:

Pharmaceutical it is incompatible with other medicines.

Contraindications:

Hypersensitivity, pregnancy.

Storage conditions:

List B. To store in the place protected from light at a temperature not above +25 °C. To store in the place, unavailable to children. Period of validity 2 years.

Issue conditions:

According to the recipe

Packaging:

On 100 and 200 ml in containers polymeric.