Neuroruby fort лактаб

General characteristics. Structure:

The operating veshchemstvo: thiamin mononitrate (Vit. B1) 200 mg
pyridoxine hydrochloride (Vit. B6) 50 mg
cyanocobalamine (Vit. B12) 1 mg

Excipients: gipromelloza, Mannitolum, cellulose powdery, cellulose microcrystallic, starch prezhelatinizirovanny, magnesium stearate, silicon dioxide colloid.

Structure of a film cover: gipromelloza, macrogoal 6000, talc, titanium dioxide (E171), erythrosine (E127).

Pharmacological properties:

Neyrorubin™-Forte Laktab™ - the drug of the combined structure containing neurotropic vitamins of group B. Active components of drug - B1, B6, B12 vitamins participate in the biochemical processes providing transfer of excitement on nerve fibrils, a metabolism, metabolism of mediators in a nervous system.

Thiamin (B1 vitamin) which is localized in membranes of nervous cells participates in carrying out nervous impulse, improves a neuranagenesis. During creation of high concentration of thiamin in blood promotes development of analgeziruyushchy effect.

The pyridoxine (B6 vitamin) influences structure and function of nervous tissue, first of all, regulating metabolism of amino acids that interferes with accumulation of neurotropic poison - ammonia. Participates in synthesis of various mediators: catecholamines, a histamine, GABA, increases intracellular reserves of the magnesium playing an important role in exchange, in particular, power processes and activity of a nervous system.

Cyanocobalamine (B12 vitamin) stimulates nucleinic exchange and participates, thus, in maintenance of a hemogenesis, and also reduces a neurogenic notsitseption.

Pharmacokinetics. Thiamin mononitrate (B1 vitamin) after peroral introduction rezorbirutsya in a duodenal and small bowel. It is substantially metabolized in a liver and its main metabolites are tiaminkarbonovy acid and pyramine (2,5-dimethyl-4-aminopyridimine). Metabolites together with a small amount of not changed thiamin are removed through intestines and kidneys.

Pyridoxine the hydrochloride (B6 vitamin) is quickly soaked up from intestines. It is metabolized in a liver with formation of pharmacological active metabolites of pyridoxal phosphate and a piridoksaminfosfat. B6 vitamin functions as coenzyme after phosphorylation of CH2OH group in the 5th situation, that is formations of piridoksal-5-phosphate (PALP). About 80% of PALP contact proteins of a blood plasma. The pyridoxine preferential collects in muscles, a liver and TsNS. An end product of metabolism of a pyridoxine is 4-piridoksilovy acid which is removed from an organism by kidneys.

Cyanocobalamine (B12 vitamin). The main amount of cyanocobalamine is acquired after linkng with an internal factor of Kastl. B12 vitamin collects preferential in a liver. T1/2 of blood serum makes about 5 days, of a liver – about 1 year. It is brought out of an organism generally with bile and with urine.

Indications to use:

As a part of complex therapy:

— neuralgia, neuritis, polyneuritis;

— neuropathy, polyneuropathy (including diabetic, alcoholic);

— neurologic displays of osteochondrosis of a backbone (ischialgia, radiculopathy, muscular and tonic syndromes).

Route of administration and doses:

Appoint inside, to or during meal. Tablets are swallowed without chewing, washing down with enough water.

The adult about 1-2 tablets / are recommended to accept

The course of treatment makes 4 weeks. The possibility of carrying out repeated courses of treatment is solved individually attending physician.

Features of use:

With care it is necessary to apply at patients with dekompensirovanny heart failure and stenocardia.

In rare instances excess daily doses of B6 vitamin (500 mg or are one extent more than more than 5 months) lead to a peripheral touch neuropathy which, as a rule, disappears after the end of administration of drug.

Pyridoxine the hydrochloride can provoke developing of acne rash.

Influence on ability to driving of motor transport and to control of mechanisms

considering that in rare instances at use of drug emergence of dizziness, weaknesses, concerns is possible, it is necessary to be careful at control of vehicles or potentially dangerous mechanisms.

Side effects:

Allergic reactions: seldom - an itch, urticaria, the complicated breath, a Quincke's edema, an acute anaphylaxis.

From the alimentary system: seldom - nausea, gastrointestinal bleedings, increase in activity of nuclear heating plant.

From cardiovascular system: in isolated cases - tachycardia, a collapse, cyanosis, a fluid lungs.

Others: seldom - sudden perspiration, feeling of weakness, dizziness, concern, acne rash, inhibition of release of prolactin.

Interaction with other medicines:

As pyridoxine the hydrochloride stimulates decarboxylation of a L-dopamine (levodopa) and can reduce therapeutic effect of this drug at treatment of patients with Parkinson's disease, it is necessary to exclude simultaneous use of these drugs.

Thiosemicarbazone also 5-ftoruratsit reduce efficiency of B1 vitamin, being his antagonists.

Antacids slow down B1 vitamin absorption.

Contraindications:

— allergic diathesis in the anamnesis;

— pregnancy;

— lactation period;

— children's and teenage age up to 18 years;

— hypersensitivity to drug components.

 

Use of the drug NEYRORUBIN™-FORTE LAKTAB™ at pregnancy and feeding by a breast

Drug is contraindicated at pregnancy and in the period of a lactation.

Overdose:

Symptoms: touch neuropathy, strengthening of side effects of drug.

Treatment: to cancel drug, to cause vomiting or to wash out a stomach, to appoint absorbent carbon. Symptomatic therapy.

Storage conditions:

Drug should be stored in unavailable to children, the dry place at a temperature not above 25 °C. A period of validity - 4 years.

Issue conditions:

According to the recipe

Packaging:

10 - planimetric strip packagings (2) - packs cardboard.