Магнелис® B6
Producer: JSC Pharmstandart Russia
Code of automatic telephone exchange: A12CC01
Release form: Firm dosage forms. Tablets.
General characteristics. Structure:
Active ingredients: contains lactate magnesium - 470 mg and a pyridoxine of a hydrochloride – 5 mg
Excipients:
Kernel: sucrose (sugar), povidone (коллидон 30), коллидон SR [polyvinyl acetate of 80%, povidone of 19%, sodium lauryl sulfate of 0,8%, silicon dioxide of 0,2%] (коллидон SR), magnesium stearate, karmelloza of sodium (sodium carboxymethylcellulose) talc.
Cover: sucrose (sugar) kaolin (clay white), gelatin, acacias gum (arabic gum), white beeswax (wax white), wax of karnaubskiya, talc, titanium dioxide.
Description: Tablets are round biconvex, coated color, white or white with a creamy shade.
Pharmacological properties:
Fills shortage of magnesium.
Magnesium is the vital element which is in all body tissues and is necessary for normal functioning of cells. Participates in the majority of reactions of a metabolism, in regulation of transfer of nervous impulses and in reduction of muscles, has spasmolytic, antiarrhytmic and antiagregantny effect.
The organism receives magnesium together with food. The lack of magnesium of an organism can be observed at disturbance of a diet (diet) or at increase in need for magnesium (at the raised exercise and intellectual stress, a stress, pregnancy, use of diuretics).
The pyridoxine (B6 vitamin) participates in many metabolic processes, in regulation of metabolism of a nervous system. B6 vitamin improves absorption of magnesium from digestive tract and its penetration into cells.
Content of magnesium in serum:
- from 12 to 17 mg/l (0,5-07 mmol/l) speak about moderate insufficiency of magnesium.
- lower than 12 mg/l (0,5 mmol/l) speak about heavy deficit of magnesium.
Pharmacokinetics. Absorption of magnesium in digestive tract makes 50% of the dose accepted inside. It is removed preferential through kidneys. In kidneys, after glomerular filtering of 70% of the magnesium which is present at plasma, it reabsorbirutsya by renal tubules in a proportion of 95% - 97%.
Indications to use:
The established deficit of magnesium isolated or connected with other scarce states.
Route of administration and doses:
Before administration of drug it is necessary to consult with the doctor.
Adults are recommended to take 6-8 pill a day.
To children 6 years (body weight more than 20 kg) are more senior than 4-6 tablets a day.
The daily dose should be divided into 2-3 receptions, to accept during food, washing down with a glass of water.
Treatment should be stopped after normalization of concentration of magnesium in blood.
Features of use:
Information for patients with a diabetes mellitus: tablets contain sucrose as excipient.
In case of the accompanying deficit of calcium, deficit of magnesium has to be eliminated prior to calcium administration of drugs.
At the frequent use of purgatives, alcohol, intense exercise and mental stresses the need for magnesium increases that can lead to development of deficit of magnesium in an organism.
Side effects:
From bodies of a GIT: abdominal pains, lock, nausea, vomiting, meteorism.
Allergic reactions: allergic reactions to drug components are possible.
Interaction with other medicines:
- Simultaneous use of the drugs containing phosphates or salts of calcium can reduce considerably absorption of magnesium in digestive tract.
- Drugs of magnesium reduce tetracycline absorption, it is recommended to divide reception of these drugs a three-hour interval.
- Magnesium weakens action of peroral thrombolytic means, reduces digestion of iron.
- B6 vitamin oppresses activity of a levodopa.
Contraindications:
Hypersensitivity to drug components, the expressed renal failure (clearance of creatinine less than 30 ml/min.), a fenilketonuriya.
Children's age – up to 6 years.
With care: at a moderate renal failure as there is a risk of development of a gipermagniyemiya.
Period of pregnancy and breastfeeding
Pregnancy: Clinical experience did not reveal the fetotoksichesky or causing defects action fetation. Магнелис® B6 can be applied during pregnancy only according to testimonies of the doctor.
Lactation period: Magnesium gets into breast milk. It is necessary to avoid use of drug in the period of a lactation and feeding by a breast.
Overdose:
At normal function of kidneys oral administration of magnesium does not cause toxic reactions. Poisoning with magnesium can develop at a renal failure. Toxic effects generally depend on the content of magnesium in blood serum.
Symptoms: falling of arterial pressure, nausea, vomiting, delay of reflexes, anury, respiratory depression, coma, cardiac standstill.
Treatment: regidratation, artificial diuresis. At a renal failure the hemodialysis or peritoneal dialysis is necessary.
Storage conditions:
In the dry, protected from light place at a temperature not higher than 25 ° C.
To store in the place, unavailable to children.
Period of validity - 2 years. Not to use after a period of validity.
Issue conditions:
Without recipe
Packaging:
Tablets, coated.
- On 60 or 90 tablets in banks polymeric. Banks cork the cover screwed and fit a cap protective thermoshrinkable.
- On 10 tablets in a blister strip packaging. Each can or 3 or 5 blister strip packagings are placed in a pack from a cardboard together with the instruction on a medical use.
