Magvit

General characteristics. Structure:

Active ingredients: 5 mg of a pyridoxine of a hydrochloride, 309,4 mg of magnesium of citrate (in terms of magnesium – 50 mg).

Excipients: magnesium stearate, lactose, potato starch.

Structure of a cover of the capsule: gelatin pharmaceutical, глицерол, нипагин, нипазол, sodium lauryl sulfate, dyes sunset yellow (E110), quinolinic yellow (E104), titanium dioxide; the water purified.

Pharmacological properties:

Pharmacodynamics. Therapeutic effect of drug is caused by pharmacological properties of magnesium and a pyridoxine of a hydrochloride.

Magnesium is is the vital element which is in all body tissues and is necessary for normal functioning of cells, participates in the majority of reactions of a metabolism, in particular, participates in regulation of transfer of nervous impulses and in reduction of muscles. 

Magnesium is a cofactor of many enzymatic reactions: hydrolysis and transfer of phosphatic group, functioning of Na + - K+-Atfaznogo, Sa2+-Atfazny and proton pumps, participates in DNA replication and a transcription of RNA.

The organism receives magnesium together with food. The lack of magnesium of an organism can be observed at disturbance of a diet (including at observance of reducing diets) or at increase in need for magnesium (at the raised exercise and intellectual stress, a stress, pregnancy, use of diuretics).

Deficit of magnesium in an organism is shown by muscular weakness, a tremor, a tetany, an ataxy, increase in reflex irritability, irritability, frustration of a dream, disturbances of a heart rhythm, and also diarrhea.

Content of magnesium in serum from 12 to 17 mg/l (0,5 – 0,7 mmol/l) speaks about moderate insufficiency of magnesium; lower than 12 mg/l (0,5 mmol/l) speak about heavy deficit of magnesium.

The pyridoxine (B6 vitamin) participates in many metabolic processes, in regulation of metabolism of a nervous system, improves lipidic exchange at atherosclerosis. The pyridoxine is necessary for phosphorylase activation, for formation of neurotransmitters, piperidic acid, glycine, serotonin.

Use of the combined drug, the containing magnesium citrate and B6 vitamin, is proved by the following data:

- Vit. B6 and magnesium supplement pharmacological action of each other;

- Vit. B6 increases concentration of magnesium in plasma and in erythrocytes and reduces amount of the magnesium removed from an organism;

- Vit. B6 improves absorption of magnesium from a GIT and its penetration into cells;

- magnesium activates process of transformation of a pyridoxine in its active metabolite piridoksal-5-phosphate in a liver;

- Vit. B6 promotes increase in content of intracellular magnesium.

Magvita who is a part water organic salt of magnesium (magnesium citrate) is well soaked up, and the pyridoxine even more increases absorbability of magnesium and its receipt in cells.

Pharmacokinetics. Absorption and distribution. After reception from a GIT about 50% of magnesium are absorbed. In an organism magnesium is distributed generally in intracellular space (about 99%) from which about 2/3 it is distributed in a bone tissue, and a third is in smooth and cross-striped muscular tissue.

The pyridoxine is soaked up in a small intestine, with a blood flow is carried to fabrics and, getting into cells, is phosphorylated with participation of ATP and pyridoxal kinases.

Removal. The main way of removal of magnesium is the urinary system. 70% of the magnesium which is present at plasma which 95-97% then reabsorbirutsya in renal tubules are exposed to glomerular filtering. The magnesium which is present at urine averages one third of the accepted magnesium.

Key product of a catabolism of a pyridoxine is 4-piridoksilovy acid which is excreted with urine.

Indications to use:

This medicine contains magnesium to which deficit in an organism the following symptoms can testify:
- nervousness, irritability, weak alarm, passing fatigue, small sleep disorders,
- manifestation of concern in the form of gastrointestinal spasms, a cardiopalmus (at healthy heart),
- muscular spasms, feeling of a pricking.

Purpose of magnesium can help to remove these symptoms. If after one month of treatment of improvement it is not observed, monotherapy continuation by this drug is inexpedient.

Route of administration and doses:

In complex treatment at deficit of magnesium in an organism drug is appointed inside to adults and children 6 years on 1-2 capsules 2-3 times a day are more senior during food. Treatment should be stopped after normalization of concentration of magnesium in blood.

Features of use:

At the accompanying deficit of calcium deficit of magnesium in an organism should be eliminated prior to calcium administration of drugs.

At combined use of tetracycline and Magvit it is necessary to observe a 3-hour interval between receptions of these drugs.

At the frequent use of laxatives, ethanol, big mental and exercise stresses the need for magnesium increases and increases risk of development of deficit of magnesium in an organism. 

Pregnancy and lactation. During pregnancy drug can be used only according to indications and under medical control.

It is not recommended to use drug during breastfeeding. Magnesium is emitted with breast milk.

Side effects:

Drug is well transferred.

From the alimentary system: seldom – abdominal pains, nausea, vomiting, a meteorism, a lock.

Others: allergic reactions are possible.

Interaction with other medicines:

At the simultaneous use of Magvit and drugs containing phosphates and salts of calcium absorption of magnesium from a GIT can decrease considerably.

Drug reduces digestion of iron, tetracycline absorption.

At combined use magnesium weakens action of peroral thrombolytic means.

The pyridoxine strengthens effect of diuretics; considerably reduces protivoparkinsonichesky effect of a levodopa, it is well combined with cardiac glycosides (promotes increase in synthesis of sokratitelny proteins in a myocardium), with glutaminic acid and an asparkam (resistance to a hypoxia increases).

Contraindications:

Contraindication to use of drug is hypersensitivity to its components, and also the expressed renal failure (KK less than 30 ml/min.), a gipermagniyemiya, children's age up to 6 years.

With care: at moderate insufficiency of function of kidneys as there is a risk of development of a gipermagniyemiya

Overdose:

Now about cases of overdose of drug of Magvit it was not reported.

Storage conditions:

Drug should be stored in the unavailable to children, dry, protected from light place at a temperature from 15 to 25 °C. A period of validity - 2 years.

Issue conditions:

Without recipe

Packaging:

On capsules 10 in blisters, on 3 blisters in packs cardboard.