Caffeine-sodium benzoate

General characteristics. Structure:

Main physical and chemical properties: tablets of white color, a ploskotsilindrichesky form, with slanted edges and risky; structure: 1 tablet contains caffeine-sodium benzoate in terms of 100% substance - 0,2 g; excipients: lactoses monohydrate, microcrystallic cellulose, starch corn, povidone, calcium stearate.

Pharmacological properties:

Pharmacodynamics. Caffeine-sodium benzoate is used preferential as a stimulator of the central nervous system. Caffeine strengthens and regulates processes of excitement in a cerebral cortex, strengthens positive reflexes, increases physical activity. The specified influence is transformed to increase in intellectual and physical effeciency, reduction of fatigue and drowsiness. Effect of drug substantially depends on type of higher nervous activity. Besides, noted effects dozozavisimy, and in high doses caffeine can lead to exhaustion of nervous cells. Drug weakens effect of hypnotic drugs and drugs, increases reflex irritability of a spinal cord, excites the respiratory and vasomotor centers. Cordial activity amplifies, reductions of a myocardium become more intensive and become frequent. The hypertensive effect Caffeine-sodium benzoate is observed only at depressed and kollaptoidny cases. The diuresis under influence Caffeine-sodium benzoate amplifies a little (mainly because of reduction of a reabsorption of electrolytes in renal tubules).
The oppression by phosphodiesterase enzyme caffeine leading to accumulation in cells of cyclic adenosinemonophosphate is the cornerstone of the mechanism of effect of drug. The last strengthens a glycogenolysis, stimulates metabolism in bodies and fabrics, including the central nervy system and muscles. An important link in the mechanism of the stimulating effect of drug is linkng of caffeine with purine receptors of a brain. 

Pharmacokinetics. Drug is well soaked up from a digestive tract. Easily gets through a blood-brain barrier. In the course of biotransformation is exposed to demethylation and oxidation. A small part (about 8%) in not changed look is allocated from an organism with urine in the form of metabolites.
At healthy people after intake of 0,1 g of caffeine the elimination half-life makes 3,9-5,3 h, the maximum concentration – 1,58-1,76 mg/l. In 24 h caffeine is completely removed.

Indications to use:

Caffeine-sodium benzoate is applied at   the diseases which are followed by oppression of functions of the central nervous system and cardiovascular system, hypotension, an asthenic syndrome at brain vasospasms (migraine), at a headache (in a combination with other medicines, for example, acetylsalicylic acid). Drug is appointed in need of mobilization of reserves of an organism, for increase in mental and physical effeciency, drowsiness elimination. At children Caffeine-sodium benzoate is applied at enuresis.

Route of administration and doses:

Caffeine-sodium benzoate is appointed inside. Doses of drug select individually. Apply 2-3 times a day. The single dose for adults inside usually makes 0,1-0,2 g; for children from 5 to 14 years inside appoint in a dose 0,025-0,1 g 2-3 times a day.  The highest doses for adults: one-time - 0,5 g, daily - 1,5 g.

Features of use:

In case of prolonged use mental dependence can develop.

Side effects:

At use (especially long) of drug sleeplessness, concern, nausea, vomiting, heartbeat can develop.

Interaction with other medicines:

Drug is combined with cardiac glycosides, atropine, bronchial spasmolytics, analgetika, ergot alkaloids, bromides.
It is incompatible with MAO inhibitors (Nialamidum). Is an antagonist of the narcotic, somnolent and other substances oppressing the central nervy system.

Contraindications:

Caffeine-sodium benzoate is contraindicated at a hyperexcitability, sleeplessness, the expressed increase in arterial pressure, atherosclerosis, at organic diseases of cardiovascular system, at advanced age, and to children up to 5 years, at glaucoma.

Overdose:

At overdose excitement, dizziness, hurried breathing, vomiting, trembling are observed.
In cases of poisonings with drug the stomach is washed out mix of the coal activated appoint an oxygenotherapy; spasms eliminate with Sibazonum (diazepam).

Storage conditions:

Store in the unavailable to children, dry, protected from light place at a temperature not above 25 °C.

Period of validity - 4 years.

Issue conditions:

According to the recipe

Packaging:

On 10 tablets in planimetric strip or bezjyacheykovy packaging. On 10 tablets in a blister strip packaging, on 1 packaging in a pack.