Vinboron

General characteristics. Structure:

International and chemical names: Phenicaberan, 2-фенил-3-карбетокси-4-диметиламинометил-5-оксибензофурана hydrochloride; main physical and chemical properties: tablets, coated, yellow color. On cross section 2 layers are visible; structure: 1 tablet contains 0,02 g or 0,04 g of a vinboron (fenikaberan); excipients: tabletoza-80, hydroxypropyl cellulose, talc, calcium stearate, film covering 39G22433 Opadry II Yellow.

Pharmacological properties:

Pharmacodynamics. Vinboron represents synthetic drug with the mestnoanesteziruyushchy, antiarrhytmic and expressed spasmolytic action. Vinboron expands coronal and brain vessels, improving coronary and cerebral circulation. Under the influence of drug absorption of glucose and oxygen brain tissues improves. Along with spasmolytic influence on vessels of a brain and heart Vinboron at long use shows antisclerous effect which is caused by reduction of amount of free cholesterol in blood serum and β-lipoproteids.......... Drug improves microcirculation and increases the volume speed of coronal blood circulation, forming at the same time in a myocardium an oxygen reserve. Important feature of Vinboron is the fact that he possesses antiagregantny action concerning thrombocytes and improves rheological indicators of blood in the conditions of hypercoagulation. Insignificant thrombolytic action shows drug. Vinboron has mestnoanesteziruyushchy effect. Antiarrhytmic action of Vinboron combines with ability to increase resistance of a myocardium to developing of arrhythmias and fibrillations. At patients with initial degree of hypertensia Vinboron can normalize arterial pressure. Drug has insignificant broncholitic effect and an immunopromoting effect which is more expressed at prolonged use of drug.

Pharmacokinetics. Vinboron is quickly soaked up in a digestive tract, distributed in all bodies and fabrics, collects in bronchial tubes and in abdominal organs more. Metabolism of drug happens in a liver which is provided with system of a tsikhrom P450, metabolites cosecrete both with bile, and with urine. The maximum concentration (Cmax) in blood is observed in 40 minutes after oral administration. The elimination half-life (T1/2) makes 157 minutes. The Pharmakoterapevtichesky effect begins to develop in 30-40 minutes and proceeds 4-6 h. Drug well gets through gistogematologichesky and hematoencephalic barriers.

Indications to use:

Cholecystitises, zhelchekamenny disease, spastic colitis, stomach ulcers and a duodenum and, as supportive application, for treatment of coronary heart disease, a tachyarrhythmia, a bronkhoobstruktivny syndrome. It is reasonable to use drug in complex treatment of disturbances of cerebral circulation.

Route of administration and doses:

Adults accept drug on 0,02 0,04 mg 3 - 4 times a day, irrespective of meal. The course of treatment averages 4–6 weeks.

Features of use:

It is necessary to be careful at purpose of drug the patient with the expressed atherosclerosis of coronal and brain vessels. Treatment by Vinboron needs to be begun under control of arterial pressure. In case of considerable pressure decrease administration of drug needs to be stopped. During treatment by Vinboron the control of vehicles is contraindicated. Use at pregnancy and a lactation is possible in case the expected advantage for mother exceeds potential risk for a fruit or the child.

Side effects:

Emergence of a headache, arterial hypotension, weakness is possible that does not demand cancellation of administration of drug. In some cases reduction of appetite and development allergic reactions.

Interaction with other medicines:

At simultaneous use drug can strengthen action of spasmolysants, anti-anginal, hypotensive and antiagregantny means.

Contraindications:

Chronic nephrite with hypostases and the broken azotovydelitelny function of kidneys, the bleeding stomach ulcers and a duodenum, hypersensitivity to drug and its components; uncontrollable hypotension, heavy renal failures and liver, hypokinesia of biliary tract; a state which is followed by disturbance of venous outflow of blood in brain vessels; children's age.

Overdose:

Now any case of overdose by Vinboron is not described. But at the increased individual sensitivity an enanthesis, a lowering of arterial pressure (ABP) is possible. Considerable decrease in indicators of the ABP demand drug withdrawal. In case of acute poisoning it is necessary to enter etaminat sodium in subnarcotic doses.

Storage conditions:

To store in the unavailable to children, dry, protected from light place at a temperature not above 25 °C.

Period of validity - 3 years.

Issue conditions:

According to the recipe

Packaging:

On 10 tablets in a blister strip packaging. On 2, either 4, or 10 blister strip packagings in a pack.