Asparkam

General characteristics. Structure:

Active ingredients: 0,175 mg of magnesium of asparaginate, 0,175 mg of potassium of asparaginate.

Excipients: starch potato or corn, talc).

Excipients: calcium октадеканоат (calcium stearate)

Pharmacological properties:

Pharmacodynamics. The asparkam is a source of potassium ions and magnesium, regulates metabolic processes. The mechanism of action is presumably connected with an asparaginate role as carrier of ions of magnesium and potassium in intracellular space and participation of asparaginate in metabolic processes. Thus, the asparkam eliminates an imbalance of electrolytes, lowers excitability and conductivity of a myocardium (moderate antiarrhytmic effect).

Pharmacokinetics. It is easily soaked up at intake and rather quickly removed by kidneys.

Indications to use:

The asparkam is applied in complex therapy at heart failure, coronary heart disease, a hypopotassemia, disturbances of a cordial rhythm (including at a myocardial infarction, overdose of cardiac glycosides).

Route of administration and doses:

The asparkam is appointed inside after food. Appoint usually adult on 1-2 tablets 3 times a day. A course of treatment - 3-4 weeks. If necessary the course is repeated.

Side effects:

Nausea, vomiting, diarrhea, unpleasant feelings or burning in epigastric area (at patients with anacid gastritis or cholecystitis), an ulceration of a mucous membrane of a GIT, bleeding from bodies of a GIT, a meteorism, dryness in a mouth are possible; bradycardia, skin itch, dizziness; a myasthenia, an adynamy, the increased sweating; atrioventricular block, paradoxical reaction (increase in number of extrasystoles), hyperpotassemia (nausea, vomiting, diarrhea, parasthesias), gipermagniyemiya (face reddening, feeling of thirst, lowering of arterial pressure, hyporeflexia, respiratory depression, spasms).

Interaction with other medicines:

Pharmakodinamicheskoye: combined use with kaliysberegayushchy diuretics (Triamterenum, Spironolactonum), beta adrenoblockers, cyclosporine, heparin, APF inhibitors, non-steroidal anti-inflammatory drugs increases risk of development of a hyperpotassemia up to development of arrhythmia and an asystolia.

Use of drugs of potassium together with glucocorticosteroids eliminates the hypopotassemia caused by the last.

Under the influence of potassium undesirable effects of cardiac glycosides decrease.

Magnesium reduces effect of Neomycinum, polymyxin B, tetracycline and streptomycin.

Anesthetics increase the oppressing effect of drugs of magnesium by TsNS; at simultaneous use with atrakuroniy, dekametoniy, suktsinilkhloridy and succinylcholine strengthening of neuromuscular blockade is possible; calcitriol increases the content of magnesium in a blood plasma, drugs of calcium reduce effect of drugs of magnesium.

Strengthens negative dromo-and bathmotropic action of antiarrhytmic HP.

Pharmacokinetic: the knitting and enveloping means reduce absorption of drug in digestive tract.

Contraindications:

Hypersensitivity to drug, disturbance of exchange of amino acids, arterial hypotension, an acute and chronic renal failure, a hyperpotassemia, a gipermagniyemiya, disturbance of atrioventricular conductivity (AV I-III of degree), a heavy myasthenia, an acute metabolic acidosis, dehydration (эксикоз), hemolysis, Addison's disease. With care appoint at pregnancy (especially the I trimester) and in the period of a lactation.

Overdose:

Symptoms: conductivity disturbance (especially at the previous pathology of the carrying-out system of heart).

Storage conditions:

To store in the dry place, at a temperature not above 20 °C. To store in the place, unavailable to children. A period of validity - 3 years. Drug cannot be used after the date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

On 10 tablets in planimetric bezjyacheykovy packaging. On 10 tablets in a blister strip packaging. On 50 tablets in glass jars or in banks polymeric. Each can or 2, 5 planimetric packagings together with the application instruction are placed in a pack from a cardboard.