Miramistin

General characteristics. Structure:

Active ingredient: 0,05 g of a miramistin in 100 g of hydrogel.

Pharmacological properties:

Pharmacodynamics. "Hydrogel plates of a miramistin" are intended for topical administration at treatment of wounds, ulcers, decubituses, burns. This wound covering has high elasticity, well models wound surfaces, sufficient durability that provides protection of a wound surface against mechanical damages. Possesses high degree of an atravmatichnost, does not stick to a wound surface that excludes a pain syndrome when bandagings, does not injure gentle granulyatsionny fabric, skin transplants.

"Hydrogel plates of a miramistin of 0,05%" well contacts to a wound surface that provides high adhesive properties of a covering. Application of "Hydrogel plates of a miramistin of 0,05%" creates an optimum microclimate in a zone of wound defect due to maintenance of the wet environment, has the plasticizing effect, softening at the same time a necrotic scab, diffusing under it, facilitating mechanical removal of impractical fabrics. The wound covering has good drainage and sorption properties thanks to what eliminirut decomposition products, wound exudate, microbic bodies, inflammation mediators from a wound surface. Applications of "Hydrogel plates of a miramistin of 0,05%" do not interfere with normal gas exchange in a wound, possessing at the same time sufficient barrier function – do not allow penetration of microorganisms from the outside, prevent re-and superinfection.

At application of Hydrogel Plates of a Miramistin of 0,05% medicine there is a cooling of a wound surface that plays an important role at treatment of burns. "Hydrogel plates of a miramistin of 0,05%" has a promoting effect on reparative processes in a wound. The antiseptic agent which is a part of medicine мирамистин is characterized by antibacterial activity concerning gram-positive, gram-negative, aerobic, anaerobic, spore-forming and asporogenic bacteria in the form of monocultures and microbic associations (including hospital strains with resistance to antibiotics) are Most sensitive to a miramistin: gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., Bac. Subtilis, etc.); mushrooms (Candida albicans, Candida tropicalis, Trichophyton rubrum, Microsporum lanosum, Aspergillis niger); gram-negative microorganisms (Escherichia coli, Salmonella spp., Shigella spp., Neisseria sp., Vibrio spp., Treponema pallidum., Corynebacterium diphtheria); protozoa (Chlamidium trachomatis, Chlamidium pneumonia). Increases functional activity of immune cells, stimulates a local nonspecific immune response, accelerates process of healing of wounds, reduces resistance of microorganisms to antibacterial drugs.

Pharmacokinetics. Miramistin badly gets through the unimpaired skin and mucous membranes thereof at topical administration of a hydrogel plate мирамистин it is practically not adsorbed in a system blood stream. Action duration after single use - 8-12 hours.

It is experimentally proved that water extracts from an application dosage form "Hydrogel plates of a miramistin of 0,05%" (1:1) do not possess systemic toxic action on an organism of animals, do not exert negative impact on the main functional systems of an organism (TsNS, cardiovascular system, function of a liver and kidneys), do not show hemolitic, cytotoxic and local irritative properties. At subchronic parenteral administration they do not irritate a peritoneum, do not induce commissural process in a peritoneal cavity, do not influence system of blood and an immunoreactivity of animals, do not cause pathomorphologic changes of internals and are biologically safe.

At contact of hydrogel plates with a wound surface, mucous, hypodermic cellulose, serous and epithelial fabrics did not reveal signs of local reaction of fabrics of the alternative, irritating or inflammatory character.

Indications to use:

The fresh traumatic wounds granulating the wounds (infected and not infected), chronic vyalogranuliruyushchy wounds, traumatic wounds with an exposure of bone and tendinous fabrics, wounds after skin plastics (application is made both on donor, and on a retsipiyentny bed), phlyctenas (amotio and a necrosis of epidermis) after full removal of nekrotizirovanny epidermis, decubituses, trophic vyalogranuliruyushchy ulcers, posttraumatic ulcers, an erysipelatous inflammation, wounds after opening of the suppurated hematomas, abscesses, an anthrax, furuncles, phlegmons in a regeneration phase, thermal burns of a 2-3 of the Art., thermal burns 3b-4 the Art. in a regeneration phase.

Route of administration and doses:

"Hydrogel plates of a miramistin of 0,05%" are applied by application directly on a wound or burn surface. Application is made after surgical treatment, a toilet of a wound. The hydrogel plate is carefully modelled according to a wound surface, fixed by gauze bandage. Medicine in the 1st and 2nd phases of a wound process with not plentiful purulent separated is applied.

Bandagings are made once a day, if necessary - every other day. In the presence the patient has wounds after an autodermoplastika, bandagings are carried out in two days. It is treated to full epithelization of a wound surface.

Features of use:

As a rule, the hydrogel plate easily is removed from a wound surface. After ee removals on a surface of a wound the mucous film consisting of mix of hydrogel and fibrin which easily is removed by means of a gauze tampon is often formed. In rare instances, there is some "drying" of a hydrogel plate that complicates its removal. In this situation it is necessary to place on a hydrogel plate the gauze napkin which is plentifully moistened with normal saline solution, or Ringer's solution for 5-10 minutes then the hydrogel plate will bulk up and it can be easily removed from a wound surface.

At application of Hydrogel Plates of a Miramistin of 0,05% medicine on traumatic wounds with defect of soft tissues, an exposure of a bone and sinews the hydrogel plate performs functions of the temporary cover fabric preventing their dehydration, a degeneration and infection. Bandagings are made according to indications. At insignificant exudation in 1-2 days, at active – daily.

On the granulating not contaminated wounds application of medicine is made after a toilet of a wound surface. Bandagings carry out in 1-2 days.

On the granulating contaminated wounds application is carried out after a necretomy, a toilet of a wound surface. Bandagings are performed daily.

At treatment of trophic vyalogranuliruyushchy ulcers – application of "Hydrogel plates of a miramistin of 0,05%" is made after a necretomy and a toilet of a wound surface. Bandagings carry out in a day, according to indications - daily.

When carrying out an autodermoplastika application is made on donor (the place of capture of a transplant) and retsipiyentny laying down. Bandaging is carried out for the 5th days at a normal current of a wound process. In the field of a donor bed the hydrogel plate can be before the end of process of epithelization.

At treatment of phlyctenas full excision of nekrotizirovanny epidermis and a toilet of a wound surface is made. "Hydrogel plates of a miramistin of 0,05%" are imposed on a pure wound surface. Bandagings are made in 1-2 days, according to indications - daily.

Decubituses: after a necretomy and a toilet the hydrogel plate is imposed on a wound surface. Bandagings are carried out daily. At emergence in a wound of granulations, lack of active infectious process – in 1-2 days. Direct application on a necrotic scab in need of its softening and removal is possible.

Thermal burns of a 2-3 of the Art. – application after excision of nekrotizirovanny epidermis directly on a burn surface. Bandagings are made daily at the expressed exudation, at moderated – in 1-2 days.

Thermal burns 3b-4 the Art. in a regeneration phase: Hydrogel Plates of a Miramistin of 0,05% medicine is applied as in a case with the granulating wounds.

Side effects:

Development of the raised fabric reaction on site of the application of "Hydrogel plates of a miramistin of 0,05%" connected with individual hypersensitivity of the patient is possible (reddening, hypostasis of integuments, soft tissues in a wound, strengthening of exudation). The specified reaction can be stopped by use of non-steroidal anti-inflammatory drugs, and if necessary - short-term use of glucocorticosteroids.

Besides, at prolonged use (more than 2 weeks) of "Hydrogel plates of a miramistin of 0,05%" in rare instances there can occur maceration of skin.

Interaction with other medicines:

Interaction of components of Hydrogel Plates of a Miramistin of 0,05% medicine with other medicines is not established, because of relative biological inertness of hydrogel, and also low level of receipt of the miramistin which is a part of hydrogel, a system blood stream.

Contraindications:

It is purulent - necrotic wounds in the I phase of a wound process with the expressed exudation. Hypersensitivity to hydrogel components, individual intolerance of a miramistin, skin diseases (eczema in an aggravation stage with the phenomena a moknutiya, syphilitic damages of skin, a tuberculosis cutis, viral and mycotic diseases of skin).

Overdose:

The overdose of medicines on the basis of hydrogel plates is not described. It is caused by relative biological inertness of a hydrogel plate, and also low level of receipt of the miramistin which is a part of a hydrogel plate, a system blood stream.

Issue conditions:

According to the recipe

Packaging:

Hydrogel plates of 0,05% 4х6 cm in packaging No. 2, No. 10; Hydrogel plates of 0,05% 6х9 cm in packaging No. 1, No. 5; Hydrogel plates of 0,05% 10х12 cm in packaging No. 1, No. 5.