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medicalmeds.eu Medicines Means for treatment of eels. Зинерит®

Зинерит®

Препарат Зинерит®. Astellas Pharma Europe B.V.(Астеллас Фарма Юроп Б.В.) Нидерланды


Producer: Astellas Pharma Europe B.V. (Astellas of Pharm Yurop B. V.) Netherlands

Code of automatic telephone exchange: D10AF.52I

Release form: Firm dosage forms. Powder for oral administration.

Indications to use:


General characteristics. Structure:

Packaging of drug represents two bottles, one of which contains active agents in the form of powder, and another - auxiliary components in the form of solution. Before mixing contents of bottles have the following structure:

Active agents (е first bottle)
                                             Nominal *                Quantity      ** Quantity
                                              quantity (mg / 30 ml)   taking into account 3,35%    taking into account 5%
Erythromycin of 100% (Ph.Eur.)                                       1200 1240                    1302
Zinc acetate dihydrate,                                                                  360,0 372,0 389,4
micronized (Ph.Eur.)

Auxiliary components (in the second bottle)
                                        Nominal
                                        quantity
                                         (/30 ml)
Diisopropyl
себакат (monograph)       7,81 (8,36 ml)
Ethanol (Ph.Eur.)                17,1 (21.6 ml)

1 ml of the prepared drug has the following structure:
- Erythromycin of 100     % 40 mg
- Zinc acetate dihydrate,
micronized       12 mg
- Diisopropyl себакат 0,25 g
- Ethanol of 0,55 g
* the amount of active components, erythromycin and zinc of acetate of a dihydrate, is increased by 3,35% for the purpose of compensation of their concentration at preparation of ready drug which nominal volume increases when mixing active components with solvent (each 1000 mg of powder are equivalent to 0,79 ml).
** additional increase in amount of active components, erythromycin and zinc of acetate of a dihydrate, by 5% is connected with preservation of the declared concentration of ready drug at storage.




Pharmacological properties:

Pharmacodynamics. Sinnerite - erythromycin - a zinc complex.
Has antiinflammatory, antimicrobic effect and komedonolitichesky action.
 
Erythromycin affects bacteriostatically the microorganisms causing acne rash: Propionibacterium acne and Streptococcus epidermidis. Zinc reduces development of a secret of sebaceous glands, has the knitting effect.
 
Pharmacokinetics. Complex communication of components of drug provides good penetration into skin of active agents. Zinc generally contacts a follicular epithelium and does not rezorbirutsya in a system blood stream. An insignificant part of erythromycin is exposed to system distribution and further is brought out of an organism.


Indications to use:

- treatment of acne rash


Route of administration and doses:

Outwardly. By means of the enclosed applicator Sinnerite apply with a thin layer on an affected area of skin 2 times a day: in the morning (before drawing a make-up) and in the evening (after washing). It is necessary to apply drug by a bottle inclination with the prepared solution down, with easy pressing. Speed of putting solution is regulated by force of pressing of the applicator skin. An approximate single dose - 0.5 ml. After drying solution becomes invisible.
 
Course duration - 10-12 weeks. In some cases perhaps clinical improvement in 2 weeks.


Features of use:

It is necessary to consider probability of development of cross resistance to other macroleads, lincomycin, clindamycin. It is necessary to avoid hit in eyes, on a mucous membrane of an oral cavity and a nose (the irritation or a burn is possible).
 
Pregnancy and lactation
 
Now it is established that use of drug during the periods of pregnancy and a lactation (breastfeeding) according to indications in the recommended doses is possible.


Side effects:

Local reactions: there can sometimes be a burning sensation, irritation, dryness of integuments in a drug site of application (as a rule, these phenomena are poorly expressed and do not demand drug withdrawal and/or performing symptomatic therapy).


Interaction with other medicines:

So far it is not established clinically significant interactions of Sinnerite with other medicines.


Contraindications:

- hypersensitivity to erythromycin and other macroleads;
- hypersensitivity to zinc


Overdose:

The accidental overdose is improbable because of features of topical administration of drug.


Storage conditions:

At a temperature from 15 to 25 °C, in the place, unavailable to children. A period of validity - 3 years. Not to apply after expiry date.


Issue conditions:

Without recipe


Packaging:

Powder for preparation of solution for external use complete with solvent in bottles on 30 ml and the applicator in a cardboard pack with the application instruction.



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