Erythromycin

General characteristics. Structure:

Active agent: erythromycin (in terms of active agent) – 10 thousand. Piece; Excipients: lanolin anhydrous, sodium disulphite (sodium metabisulphite, sodium pyrosulphite), vaseline.

Pharmacological properties:

Bacteriostatic antibiotic from group of macroleads. At external use has antibacterial and antiacne effect. Reversibly communicates with 50S in subunit of ribosomes that breaks formation of peptide bonds between molecules of amino acids and blocks protein synthesis of microorganisms (does not influence synthesis of nucleic acids). At use in high doses depending on a type of the activator can show bactericidal action. The action spectrum includes gram-positive (Staphylococcus spp., Streptococcus spp., Bacillus anthracis, Corynebacterium diphtheriae) and gram-negative (Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp.) microorganisms, and also Mycoplasma spp., Chlamidia spp., Treponema spp., Rickettsia spp. Gram-negative sticks of Escherichia coli, Pseudomonas aeruginosa, and also Shigella spp are steady against drug., Bacteroides fragilis, Enterobacter spp., Etc.

Indications to use:

Infections of skin and soft tissues (pustulous diseases of skin, including youthful eels, contaminated wounds, decubituses, burns of the II-III Art., trophic ulcers).

Route of administration and doses:

Outwardly: ointment is applied on affected areas of skin by 2-3 times a day, treatment duration – 1,5-2 months. At purulent diseases of skin and soft tissues ointment is applied on an affected area of skin a thin layer by 1-2 times a day after removal of necrotic masses and pus, at burns – 2-3 times a week. Duration of treatment depends on a form and disease severity and makes from several days to 2 weeks.

Features of use:

Before use of any other antiacne  medicine for external use there have to pass not less than 1 h.
If during 3-4 weeks the condition of acne rash does not improve, it is necessary to consult with the doctor (for achievement of full therapeutic effect 2-3 months can be required.
At prolonged use development of superinfection is possible.

Side effects:

Development of allergic reactions and irritant action (reddening, itch) is possible. At prolonged use the consecutive infection caused by microorganisms, steady against erythromycin, can develop.

Interaction with other medicines:

Drug is incompatible with lincomycin, clindamycin, chloramphenicol (antagonism).
Reduces bactericidal action beta лактамных antibiotics (penicillin, cephalosporins, karbopenema).
At simultaneous use of dosage forms of erythromycin for external use with the abrasive substances leading to excessive irritation of skin and also with the medicines causing a skin peeling the cumulative irritating or drying-up effect is possible.

Contraindications:

Individual hypersensitivity. 
Use at pregnancy is not specified.

Overdose:

Data on overdose of drug are absent.

Storage conditions:

List B. At a temperature from 15 to 25 °C. To store in the places unavailable to children. 
Period of validity 3 years. Not to use drug after the expiry date specified on packaging.

Issue conditions:

According to the recipe

Packaging:

Ointment for external use of 10 thousand. Piece/g.