Potassium and magnesium BH asparaginate

General characteristics. Structure:

Potassium hydroxide,                                           about 3,854
 
Magnesium oxide,                                                about 1,116
 
DL – aspartic acid,                          about 15,160
 
Ksilitol,                                                      about 16,700
 
Water for injections,                                         about 976,2
 
To +, mmol                                                           58,4
 
Mg2+, mmol                                                       27,7

Main physical and chemical properties:

Theoretical osmolarity, мОсмоль                310
 
Value рН                                                    6,0 - 7,4
 
Titrable acidity to рН 7,4, mmol       no more than 2,0
 
Maintenance of energy, kcal                                   110
 
Maintenance of energy, kJ                                  461,4
 
Content of the general nitrogen,                               about 1,59

Pharmacological properties:

To + is one of the most widespread cations in a human body; participation of a combination of K+ and Mg2 + is revealed in many fundamental processes of an organism: excitability and conductivity of nerve and muscle fibers, cellular metabolism, cordial activity, water and electrolytic balance, renal function, etc.

Indications to use:

For elimination of deficit of potassium and magnesium as supportive application at various displays of coronary heart disease, including an acute myocardial infarction: chronic circulatory unefficiency; disturbances of a heart rhythm (the arrhythmias caused by overdose by cardiac glycosides).

Route of administration and doses:

Only for intravenous administration!

The dose of drug approaches individually, depending on the indication use.

If other appointments are not available, indicative data are served by the following recommendations:
Appoint 1-2 administrations of solution for infusions on 500 ml a day slowly, kapelno. Rate of administering: 15-45 drops a minute depending on individual portability.

One week prior to cardiac intervention and within a week after heart operation enter 500 ml of Potassium and magnesium of asparaginate Berlin-Hemi in days.

Features of use:

To use only transparent solutions in the unimpaired bottles! After opening of capacity with drug of Potassium and magnesium asparaginate Berlin-Hemi it needs to be used at once. Intravenous administration of drug has to be carried out slowly. If when mixing with other injection or infusion solutions opacification or opalescence appears, then for safety these mixes cannot be used.

Side effects:

At observance of the recommended speed of drop introduction of by-effects it was not observed.

At bystry intravenous administration all symptoms of a hyperpotassemia and a gipermagniyemiya as, for example, muscular weakness, frustration from the central nervous system - fatigue, paresis, the coma, lack of reflexes, nausea, vomiting, disturbance of conductivity of a myocardium, and also in rare instances at intravenous administration is possible paradoxical reaction in the form of increase in number of extrasystoles can appear.

Interaction with other medicines:

Simultaneous use of kaliysberegayushchy diuretics and/or inhibitors of the angiotensin-converting enzyme (ACE) can lead to a hyperpotassemia and a gipermagniyemiya.

Contraindications:

Hypersensitivity to drug (including to sorbitol), an acute and chronic renal failure, a hyperpotassemia, a gipermagniyemiya, insufficiency of bark of adrenal glands, shock, an atrioventricular block of the I-III degree, an oliguria anury, an acute metabolic acidosis, a heavy myasthenia, dehydration, arterial hypotension, Addison's disease.

With care: to apply only carefully having weighed a ratio of advantage and risk at: the expressed abnormal liver functions, a metabolic acidosis, danger of developing of hypostases, an impaired renal function - if carrying out regular control of the content of magnesium in blood serum is impossible (danger of cumulation, toxic level of magnesium), the lowered phosphate level in blood, the urolithic diathesis connected with disturbance of exchange of calcium, magnesium and ammonium of phosphate, pregnancies and in the period of a lactation.

Overdose:

At bystry introduction or at administration of drug in doses which considerably exceed therapeutic symptoms of development of a hyperpotassemia (a muscular hypotone, paresthesias of extremities, delay of atrioventricular conductivity, arrhythmia, a cardiac standstill), gipermagniyemiya are possible that is shown by face reddening, the thirst expressed by a lowering of arterial pressure, neuromuscular transmission disturbance, oppression of a respiratory center, arrhythmia, spasms.

Treatment: immediate drug withdrawal, enter calcium a gluconate of 10%, for correction of the arisen cardiovascular disturbances symptomatic therapy. In case of need - a hemodialysis.

Storage conditions:

At a temperature from 15 °C to 25 °C. Not to freeze!

To store in the place, unavailable to children!

Period of validity 2 years. Expiration date of a period of validity of drug is given on a bottle.

After the expiration of the specified period of validity drug cannot be used!

Issue conditions:

According to the recipe

Packaging:

On 250 or 500 ml of drug in bottles:
1.iz transparent glass like II (Evr. T.), closed a brombutilovy rubber stopper (Evr. T.) and a plastic cover under an aluminum running in, or
2. from polyethylene of low density (Evr. T.), supplied with the eurocap which is welded on upon a bottle.

On 1 or 10 bottles together with the application instruction place in a cardboard pack.