Depresil

General characteristics. Structure:

Active agent: 300 mg of the dry standardized St. John's Wort grass extract (Hypericum perforatum L. herbae extr. sicc.), in which not less than 0,9 mg of a giperitsin;

Other components: cellulose microcrystallic, magnesium stearate, sodium carboxymethylcellulose, silicon dioxide colloid, gidroksipropilmetiltsellyuloza, titanium dioxide, polyethyleneglycol 400, ferrous oxide yellow.

Pharmacological properties:

Pharmacodynamics. Depresil is antidepressant of a plant origin, received on the basis of the standardized St. John's Wort grass extract, promotes improvement of mood and normalization of the psychoemotional status. The mechanism of action it is based on depression of the return capture of such neurotransmitters as: serotonin, noradrenaline, dopamine, GAMK, and also L-glutamd. Medicine inhibits a monoaminooxidase (MAO) and catechol-au-methyltransferase, modulates secretion interleykina-6 thanks to what shows not only antidepressive action, but also anxiolytic (elimination feeling of alarm, tension). Antiinflammatory action the kappa In, and also a proteinaceous kinase of Page is raised with suppression release of arachidonic acid and a nuclear factor.
Drug does not kumulirut.

Pharmacokinetics. Absorption. Absorption of a giperitsin and psevdogiperitsin results in digestive tract where their maximum concentration is observed. The maximum concentration after a single dose of drug in a dose of 300 mg is reached in 4,5 hour for a giperitsin and 1,5 hour for a psevdogiperitsin and makes 1,5 and 2,7 ng/ml respectively.

Elimination (removal). The elimination half-life makes 24,8 hour for a giperitsin and 16,3 hour for a psevdogiperitsin.

Indications to use:

Depression, psychovegetative disturbances that are followed by such symptoms as apathy, braking, alarm, concern, irritability, disturbance of an emotional state, a sleep disorder, decrease in body weight, feeling of powerlessness, decrease in working capacity; neurovegetative disturbances in the period of a menopause; mood swings, are connected with change wait a moment; excitement and/or nervous tension, asthenoneurotic syndrome.

Route of administration and doses:

Depresil apply orally before food, washing down with water.
Adults and children are more senior than 12 years: it is recommended to accept on 1 tablet of Depresil 3 times a day.
The therapeutic effect is shown on 10 - the 14th put uses. Duration of treatment is not limited, however in 8 weeks of administration of drug it is necessary to take a several-week break.

Features of use:

Use of drugs which contain St. John's Wort extract can cause hypersensitivity before solar radiation, especially in persons with light skin therefore during Depresilu's reception it is necessary to avoid intensive insolation, it is recommended to apply sun-protection means.
If in 4 - 6 weeks of use there does not occur improvement of a state, then drug needs to be cancelled.


Pregnancy and lactation
Use of drug is possible only when the expected advantage for mother exceeds potential risk for a fruit.

Influence on ability to manage vehicles and moving mechanisms which need big attention of concentration.
Drug does not influence ability of driving by transport and works with difficult mechanisms.

Side effects:

At reception of the recommended dosage drug it is good to be transferred. In especially sensitive persons there can be a photosensitization, is very rare – the dispepsichesky phenomena, skin allergic reactions.

Interaction with other medicines:

Active ingredients of extract of a St. John's Wort can cause induction of enzymes which participate in metabolism of other medicines (P450 cytochrome isoenzymes: 1A2, 3A4 and 2C9). At simultaneous use Depresil can reduce efficiency of warfarin, digoxin, theophylline, cyclosporine and inhibitors of proteases (e.g., an indinavira), and also oral contraceptives. Use of drugs on the basis of St. John's Wort extract with antidepressants which slow down the return serotonin reuptake is not recommended simultaneous.

Contraindications:

Hypersensitivity to drug, photosensitivity. Children up to 12 years.

Overdose:

Overdose cases are not described.

Storage conditions:

To store in the unavailable to children, dry, protected from effect of light place at a temperature up to 25 °C.

Issue conditions:

Without recipe

Packaging:

On 10 tablets in the blister; on 1, on 3 or on 6 blisters in a cardboard box.