Histoplasmosis (Disease of Darling)
Contents:
Description:
Histoplasmosis (disease of Darling) - a natural and focal zayobolevaniye. The Mitselialny phase of mushrooms lives in the soil, preiyomushchestvenno in a zone of dwelling of birds and rodents, is the most frequent in the valley of the rivers.
Infection of the person results from inhalation of the pyyola containing mushroom chlamydospores. From the sick person or an animal the activator is not transferred. The disease наблюдается is preferential at workers of poultry farms, miners, doyorozhny workers, villagers. More often men and children are ill. During the work with culture of mushrooms perhaps vnutrilabora-torpy infection in this connection the relevant laboratories have to work in the mode of especially dangerous infections. Gistoyoplazmoz is widespread preferential in tropical strayona.
Histoplasmosis symptoms (Diseases of Darling):
In most cases гистоплазмоз proceeds latentno. Acute histoplasmosis of lungs is described as an epidemic disease with an incubation interval of 1 - 2 week. In mild cases proceeds in the form of an acute respiratoryony disease and comes to an end with recovery in 10 - 15 days. X-ray inspection reveals in lungs the small small infiltrates described as "blizzard", "blizzard", "wadded flakes", etc. Hard cases of a disease can remind an atypical chronic pnevyomoniya and proceed 8 - 10 months and more. Characteristic discrepancy of the scanty data obtained at a perkusyosiya and auscultation, and the expressed radiological izmeneyoniya in the form of the extensive bilateral interstitsialyiy infiltyoration which is often followed by a hyperadenosis of a mediastinum and a shadow of roots of lungs yavyolyatsya. A frequent outcome of a proyotsess is miliary calcification of lungs.
Sometimes histoplasmosis of lungs proceeds with formation of a gistoplazmoma - big roundish infiltrate, trudyonootlichimy from lung cancer. In some cases at histoplasmosis changes from lymph nodes of a root of a lung prevail that causes a stsnozirovaniye of vascular and bronchial trunks, their obturation, emergence of atelektayoz, a syndrome of an average share, etc.
Larger scattered centers or infiltrative focuses inclined to disintegration are characteristic of the secondary chronic disseminated histoplasmosis of lungs, it is frequent сочетающиеся with polilimfoadenity, a hepatolienal syndrome, anemia and a leukopenia.
Histoplasmosis reasons (Diseases of Darling):
The activator — Histoplasina capsulatum — is presented by several options: N of dubiosii (causative agent of the African histoplasmosis), N. of farsiminosum (causative agent of histoplasmosis of horses), N. muris (causative agent of histoplasmosis of mice).
Treatment of Histoplasmosis (Diseases of Darling):
Causal treatment is carried out by sulfanilyoamidny drugs (Norsulfazolum on 4-6 g a day), statine (4-6 million. Piece a day), Amphotericinum of B (1-1,5 mg on 1 kg of body weight a day) and its derivatives - amfoglyukami-number (200-500 thousand. Piece twice a day), mikogepiny (po280mg twice a day). Hemotransfusions, introduction of a blood plasma, donor uglobulin are shown.
The forecast at a pulmonary form favorable, at a generaliyozovanny form - bad.
